52. Severe epithelial dysplasia
1 )-Loss of polarity of basal cells or
loss of cellular orientation
2)- Basilar hyperplasia
3 )-Formation of cell nests
4 )- Formation keratin pearls
5 )-Abnormal keratinization
(individual cell keratinization )
6 )- Hyperchromatic nuceli
7 )- Increased or change in nuclear /
cytoplamic ratio
8 )- Large prominent nucleoli
9 )-Increased normal and abnormal
mitoses with Nuclear and
cellular pleomorphism
10 )-Division of nucleus is without
division of cytoplasm , which is
called ( Poikilokaryonosis )
11)- Loss of interacellular bridges
(Desmosome Junction)
12)-Drop –shaped rete ridges
13)-Loss of normal epithelial
stratification or maturation )