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Aerosole

Aerosole by Mr. Vishal Shelke
https://youtube.com/vishalshelke99
https://instagram.com/vishal_stagram

Sub :- Advanced Pharmaceutics
M.Pharmacy Semister 1 (50 Marks Seminar)
Savitribai Phule Pune University

Contents
Introduction

Formulation of Aerosol

Delivery Systems
- Metered Dose Inhalers
- Dry Powder Inhalers

Applications of Aerosol

Marketed Preparations

References

INTRODUCTION
Aerosol or Pressurized package is defined as “A system that depends on the power of a compressed gas or liquefied gas to expel the contents from the container.”[1]

Pharmaceutical Aerosol is defined as aerosol product containing active ingredients dissolved , suspended or emulsified in a propellant or a mixture of solvent or propellant and intended for oral or topical administration.[1]

Formulation of Aerosol
It consist of three essential components :-

Product concentrate

Propellant

3. Delivery System



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Aerosole

  1. 1. “AEROSOL” Presented by Vishal D Shelke M Pharm Sem-I Guided By :- Dr. S.R Hardikar Department of Pharmaceutics Pune District Education Association’s Seth Govind Raghunath Sable College Of Pharmacy, Saswad. Presentation on
  2. 2. Contents  Introduction  Formulation of Aerosol  Delivery Systems - Metered Dose Inhalers - Dry Powder Inhalers  Applications of Aerosol  Marketed Preparations  References
  3. 3. INTRODUCTION • Aerosol or Pressurized package is defined as “A system that depends on the power of a compressed gas or liquefied gas to expel the contents from the container.”[1] • Pharmaceutical Aerosol is defined as aerosol product containing active ingredients dissolved , suspended or emulsified in a propellant or a mixture of solvent or propellant and intended for oral or topical administration.[1]
  4. 4. Formulation of Aerosol It consist of three essential components :- 1. Product concentrate 2. Propellant 3. Delivery System
  5. 5.  Product concentrate :- Active ingredient or mixture of active ingredients and other necessary agents such as solvents, anti oxidants and surfactants.[1] Aerodynamic Diameter :- - the diameter of the spherical particle with a density of 1000 kg/m3 and the same settling velocity as the irregular particle. - In many situations, while developing aerosols; we don’t need to know the true size, shape factor, and density if we know its aerodynamic diameter. [2]
  6. 6.  Propellant :- • Single or blend of various propellants is used. • Blend of solvents is used to achieve desired solubility characteristics. • Various surfactants are mixed to give the proper HLB value for emulsion system. • The propellants are selected to give the desired vapor pressure, solubility and particle size.
  7. 7. • Pharmaceutical aerosol may be dispensed as fine mist, wet spray, quick breaking foam, stable foam, semi solid etc. Type of system selected depends on, 1. Physical, chemical and pharmacological properties of drug. 2. Site of application.[1]
  8. 8. Delivery Systems  Metered-Dose Inhalers  Dry Powder Inhalers Pharmaceutical aerosols including metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are devices that deliver a specific quantity of drug to the lungs. The particle size distribution and shape of the delivered dose is more critical for inhalation aerosols than for most other conventional drug products because these factors greatly influence the deposition profile in the lungs of the patient. The optimum aerodynamic particle size distribution for most inhalation aerosols has generally been recognized as being in the range of 1-5 µm.
  9. 9. Metered-Dose Inhalers :-
  10. 10. A metered-dose inhaler (MDI) is a device that delivers a specific amount of medication to the lungs, in the form of a short burst of aerosolized medicine that is usually self- administered by the patient via inhalation. It is the most commonly used delivery system for treating asthma, chronic obstructive pulmonary disease (COPD) and other respiratory diseases. The medication in a metered dose inhaler is most commonly a bronchodilator, corticosteroid or a combination of both for the treatment of asthma and COPD. Other medications less commonly used.
  11. 11. The MDI device consists of a canister, and actuator, and sometimes a spacer. The canister itself consists of a metering dose valve with an actuating stem. The formulation resides within the canister and is made up of the drug, a liquefied gas propellant, and often stabilizing excipients. Actuation of the device releases a single metered dose of liquid propellant that contains the medication. The volatile propellant breaks up into droplets which then evaporate, creating an aerosol containing micronized drug that is inhaled into the lungs.
  12. 12. Dry Powder Inhalers :- A dry-powder inhaler (DPI) is a device that delivers medication to the lungs in the form of a dry powder. DPIs are commonly used to treat respiratory diseases such as asthma, bronchitis, COPD & diabetes mellitus
  13. 13. DPIs are an alternative to the aerosol-based inhalers commonly called metered-dose inhaler (or MDI). The DPIs may require some procedure to allow a measured dose of powder to be ready for the patient to take. The medication is commonly held either in a capsule for manual loading or a proprietary from inside the inhaler. Once loaded or actuated, the operator puts the mouthpiece of the inhaler into their mouth and takes a sharp, deep inhalation holding their breath for 5–10 seconds. The dose that can be delivered is typically less than a few tens of milligrams in a single breath since larger powder doses may lead to provocation of cough.[3][4]
  14. 14. Applications of Aerosoles :- Topical Aerosols :- The use of topical aerosols applying the drug in a convenient manner on affected area. The formulation can be applied to the desired surface area without the use of the fingertips like other types of topical preparations. E.g Convenient aerosol packages for use on the skin include the anti-infective agents like povidone iodine, tolnaftate, adrenocortical steroids like betamethasone dexamethasone acetonide.
  15. 15. Oral Aerosols :- Aerosols are used to deliver the drugs to the oral cavity generally administer the product sublingually. For example sublingual nitroglycerin aerosol formulation is sprayed under the tongue and it delivers 0.4 mg of nitroglycerin per actuation depends on the valve used.
  16. 16. Inhalation Aerosols/ Nasal Aerosols :- Inhalation aerosols deliver the drug directly to the nasal mucosa of nose. The most of nasal aerosols contain steroids, which are used to treat sneezing, nasal congestion and running nose along with hay fever, rhinitis and allergies. E.G beclomethasone dipropionate, dexamethasone sodium phosphate.[5]
  17. 17. Marketed Preparations Brand Name Drug Use Flovent Diskus Fluticasone Asthma Advair Fluticasone & Salmeterol Asthma Airobid Flunisolide Asthma Qvar Beclomethasone Asthma Proventil Albuterol Bronchospasm
  18. 18. Brand Name Drug Use Pulmicort Flexhaler Budesonide Asthma Singulair Montelukast Asthma, Allergy Accolate Zafirlukast Controlling symptoms of Asthma Zyflo Zileuton Prevent Asthma attack & for long term management of Asthma Serevent Diskus Salmeterol COPD Foradil Aerolizer Formoterol Asthma, Brochospasm, COPD Dulera Mometasone Asthma
  19. 19. References 1. “ Leon Lachman, Herbert A. Lieberman . The Theory and Practice of Industrial Pharmacy, Indian edition, CBS Publishing House 2009. 589 618.’’ 2. Wikipedia 3. “ Mark Gibson. Pharmaceutical Preformulation and Formulation, Indian edition, Interpharm/CRC ; 317,361,364 ” 4. www.horiba.com 5. www.pharmainfo.net
  20. 20. References 6. www.slideshare.net 7. www.authorstream.com 8. N.K Jain. Pharmaceutical Product Development, CBS Publishing House. 234, 338. 9. Michael E. Aulton’s. The Design & Manufacture of Medicines, 3rd Edition, Elsevier Publications. 70, 97. 10. Herbert A. lieberman, Martin M. Rieger & Gilbert S. Banker. Pharmaceutical Dosage forms : Dispense Systems Vol -3, 2nd Edition. 495-498.
  21. 21. References 11. Loyd V. Allen, Jr. Nicholar G.Popovich, Ansel’s Pharmaceutical Dosage Forms & Drug Delievery Systems, 8th Edition, Wolten Kluwerer Publications, 434 - 435.
  22. 22. Also available on Youtube! Youtube :- https://youtube.com/vishalshelke99 Instagram :- https://instagram.com/vishal_stagram

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