This document discusses solubility and various techniques to improve drug solubility. It defines solubility and solubilization. It notes that drug effectiveness depends on solubility and bioavailability. It then describes techniques like spray freezing into liquid, ultra-rapid freezing, kneading, co-precipitation, and use of solubilizing agents to improve drug solubility. These techniques are aimed at developing drugs with improved solubility and permeability.

1. Presented By :- Mr. Vishal D Shelke
Guided By :- Dr. S Hardikar.
M.Pharmacy Sem – I
Department of
Pharmaceutics

2. Solubility :-
“Solubility is the property of a solid, liquid, or
gaseous chemical substance called solute to dissolve in
a solid, liquid, or gaseous solvent to form a
homogeneous solution of the solute in the solvent.”
Solubalization :-
“ A Preparation of thermodynamically stable
isotropic solution of a substance normally insoluble or
slightly soluble in a given solvent by introduction of
an additional component

3.  Therapeutic efeectivness of a drug depends upon the
bioavailability & ultimately upon the solubility of drug
molecules
 Solubility is one of the important parameter to achieve
desired concentration of a drug in systemic circulation
for pharmacological ressponse to be shown.
 Currently only 8% of new drugs have both high
solubility & Permeability.
 Nearly 40% of the new chemical entities currently
being discovered are poorely water soluble

4.  Spray freezing into liquid (SFL)
 Ultra-Rapid Freezing
 Kneading Technique
 Co-precipitation
 Solubalizing Agents

5.  Spray Freezing Into Liquid (SFL)

6.  Ultra-Rapid Freezing
Ultra-rapid freezing is a novel technology that creates nano-
structured drug particles with greatly enhanced surface area.
The technology has the flexibility to produce particles of varying
particle morphologies. This process involves freezing a dissolved
drug in a aqueous of anhydrous polymer water solution onto the
surface of a cryogenic substrate with a thermal conductivity (k)
between 10 and 20 W/(m K), collecting the frozen particles and
removing the solvent, resulting in highly porous, agglomerated
particles.

7.  Kneading Technique
In this technique, cyclodextrin (CD) is mixed with water
and converted to paste. Drug is then added and kneaded
for specified time. The kneaded mixture is then dried
and passed through sieve if required

8. Required amount of drug is added to the solution of β-CD.
The system is kept under magnetic agitation with controlled
process parameters and protected from the light. The
formed precipitate is separated by vacuum filtration and
dried at room temperature
 Co-precipitation

9.  Solubalizing Agents
The solubility of poorely soluble drug can
also be improved by various solubilizing
materials
Eg. PEG 400 is improving the solubility of
hydrochlorthiazide85

10. Reference :-
1) ijpsr.com
2) slideshare.net
3) Wikipedia

11. Also available on Youtube!
Youtube :- https://youtube.com/vishalshelke99
Instagram :- https://instagram.com/vishal_stagram