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Methods of Solubility Enhancement

Methods of Solubility Enhancement bt Mr.Vishal Shelke
https://youtube.com/vishalshelke99
https://instagram.com/vishal_stagram

Sub :- Biopharmaceutics & Pharmacokinetics
M.Pharmacy Sem 1
Savitribai Phule Pune University

Introduction :-
Solubility :-
“Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent.”

Solubalization :-
“ A Preparation of thermodynamically stable isotropic solution of a substance normally insoluble or slightly soluble in a given solvent by introduction of an additional component

Importance of Solubility :-
Therapeutic efeectivness of a drug depends upon the bioavailability & ultimately upon the solubility of drug molecules

Solubility is one of the important parameter to achieve desired concentration of a drug in systemic circulation for pharmacological ressponse to be shown.

Currently only 8% of new drugs have both high solubility & Permeability.

Nearly 40% of the new chemical entities currently being discovered are poorely water soluble

Methods :-
Spray freezing into liquid (SFL)

Ultra-Rapid Freezing

Kneading Technique

Co-precipitation

Solubalizing Agents


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Methods of Solubility Enhancement

  1. 1. Presented By :- Mr. Vishal D Shelke Guided By :- Dr. S Hardikar. M.Pharmacy Sem – I Department of Pharmaceutics
  2. 2. Solubility :- “Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent.” Solubalization :- “ A Preparation of thermodynamically stable isotropic solution of a substance normally insoluble or slightly soluble in a given solvent by introduction of an additional component
  3. 3.  Therapeutic efeectivness of a drug depends upon the bioavailability & ultimately upon the solubility of drug molecules  Solubility is one of the important parameter to achieve desired concentration of a drug in systemic circulation for pharmacological ressponse to be shown.  Currently only 8% of new drugs have both high solubility & Permeability.  Nearly 40% of the new chemical entities currently being discovered are poorely water soluble
  4. 4.  Spray freezing into liquid (SFL)  Ultra-Rapid Freezing  Kneading Technique  Co-precipitation  Solubalizing Agents
  5. 5.  Spray Freezing Into Liquid (SFL)
  6. 6.  Ultra-Rapid Freezing Ultra-rapid freezing is a novel technology that creates nano- structured drug particles with greatly enhanced surface area. The technology has the flexibility to produce particles of varying particle morphologies. This process involves freezing a dissolved drug in a aqueous of anhydrous polymer water solution onto the surface of a cryogenic substrate with a thermal conductivity (k) between 10 and 20 W/(m K), collecting the frozen particles and removing the solvent, resulting in highly porous, agglomerated particles.
  7. 7.  Kneading Technique In this technique, cyclodextrin (CD) is mixed with water and converted to paste. Drug is then added and kneaded for specified time. The kneaded mixture is then dried and passed through sieve if required
  8. 8. Required amount of drug is added to the solution of β-CD. The system is kept under magnetic agitation with controlled process parameters and protected from the light. The formed precipitate is separated by vacuum filtration and dried at room temperature  Co-precipitation
  9. 9.  Solubalizing Agents The solubility of poorely soluble drug can also be improved by various solubilizing materials Eg. PEG 400 is improving the solubility of hydrochlorthiazide85
  10. 10. Reference :- 1) ijpsr.com 2) slideshare.net 3) Wikipedia
  11. 11. Also available on Youtube! Youtube :- https://youtube.com/vishalshelke99 Instagram :- https://instagram.com/vishal_stagram

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