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HEME SYNTHESIS

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HEME SYNTHESIS

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Succinyl CoA Glycine δ- Aminolevulinate 2 δ- Aminolevulinate Porphobilinogen 4-Porphobilinogen Uroporphyrinogen III Coproporphyrinogen III Protoporphyrinogen III Protoporphyrin IX Heme δ- Aminolevulinate Synthase δ- Aminolevulinate dehydratase Uroporphyrinogen I Synthase & uroporphyrinogen III cosynthase Uroporphyrinogen decarboxylase Coprophyrinogen oxidase Protophyrinogen oxidase Ferrochelatase Fe2+ 4H+ 4CO2 4CO2 4NH3 4H2O CoASH Synthesis of heme
HEME SYNTHESIS

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HEME SYNTHESIS

  • 1. Succinyl CoA Glycine δ- Aminolevulinate 2 δ- Aminolevulinate Porphobilinogen 4-Porphobilinogen Uroporphyrinogen III Coproporphyrinogen III Protoporphyrinogen III Protoporphyrin IX Heme δ- Aminolevulinate Synthase δ- Aminolevulinate dehydratase Uroporphyrinogen I Synthase & uroporphyrinogen III cosynthase Uroporphyrinogen decarboxylase Coprophyrinogen oxidase Protophyrinogen oxidase Ferrochelatase Fe2+ 4H+ 4CO2 4CO2 4NH3 4H2O CoASH Synthesis of heme