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NEUROLOGICAL
EXAMINATION
            Dr Ahmed Youssef
Lecturer of internal medicine & nephrology
History
• Personal H:                        • Past H:
  – Handness                         2T       Trauma, TB
  – Occupation (driver)
                                     2S       Syphilis, Similar attack
                                     2H       HTN,      Heart disease
• C/O:                               2D       DM, Drugs
  – Onset, course & duration
                                     1E       ENT
                                     1F       Fever
• Family H:
  – Heredofamilial ataxia
  – Familial periodic paralysis      • HPI:
  – Peroneal mus. atrophy
                                          – 12 items
HPI
• Motor     • Cranial n • Speech   • Mental

• Sensory   • ↑ ICT    • Sphincter • Hypoth

• Trophic   • Fits     • Gait      • Other
Motor
         •   Involuntary: extra ∆ , fasiculation
         •   State
         •   Tone                        •Dist or prox
                                         •Stat or Kinetic
         •   Weakness                    •Disappear e sleep or Not

         •   Ataxia (cerebellum)
                                        •UL or LL
•Drunken gait                           •Rt or Lt
•Intension tremors                      •Dist or Prox
•dysdidoko                              •Flexor or Extensor
•+ve romberge                           •Abductor or Adductor
•Improve on bed
Sensory
• Superficial: Pain, Temp, Touch
• Deep: Position, Mov., Vibr.             If +ve : pattern
                                                •Sensory level
• Cortical: Steriog, T. loc., T. discr.         •hemihypoth
                                                •Glove & stock
                                                •Jacket loss




        Trophic changes or deformities
• Ulcers: (N.B. : painless)
• ①:                    Cranial n
 • Anosmia
                  •     :                •      ,    :
                      • Sensory          •
• ②:                     • Tast ant ⅔
                                             Dysph (phar)
 • Acuity                                •   N. regur (palat)
                      • Motor
 • Field                                 •   N. tone (palat)
                         • Eey clos.
                         • Mouth clos.   •   Hoarsn (lary)
• ③,④,⑥:
 • Diplopia       •     :                •      :
 • Ptosis             • Deaf             • Shoulder elev
 • Squint             • Tinitus          • neck side mov
                      • Vertigo
• ⑤:                                     •      :
 • Sensory                               • Tounge mov
    • Pain,Temp
 • Motor
    • Masticat.
↑ ICT
• Papilledema
• Headache
• Vomiting

                       Fits
•   Aura
•   Post effect
•   Cons. Loss
•   Gener. Or local
•   March
Speech
• Aphasia: (higher neurolo. center lesion):
  – Receptive(sensory):
     • Spoken(Auditory)(aud recogn area lesion)
     • Written(Visual)(visual recogn area lesion)
  – Expressive(motor):
     • Spoken (broca’s area lesion)
     • Written(Agraphia)(exner’s area lesion)
• Dysarthria: (articul system lesion):
  – ∆: bilateral→ slurred (psudobulbar)
  – Extra ∆ → slow monotonus
  – Cerebellar → stacatto
  – Cr n → slurred (true bulbar)
Sphincters

                    Gait

                   Mental
• Consciousness
• Hallucination
• Memory
Hypothalamus
•   D.I.
•   Polyphagia
•   Hypogonadal
•   Hypersomnia
•   Hyperpyrexia

        Other systems affection
Examination
 • General examination

  • Neurological examination:
• Motor      • Cranial n • Speech   • Mental

• Sensory   • ↑ ICT      • Sphincter • Hypoth

• Trophic   • Fits       • Gait     • Other
Mental
•   Consciousness
•   Memory
•   Mode
•   Orientation
•   Behavior
•   Intelligence
EXAMINATION – LEVEL OF
              CONSCIOUSNESS (AROUSAL)
   Level of Consciousness (Arousal): Techniques and Patient Response
Level         Technique                                          Abnormal Response
Alertness     Speak to the patient in a normal tone of voice.
              An alert patient opens the eyes, looks at you,
              and responds fully and appropriately to stimuli
              (arousal intact).
Lethargy      Speak to the patient in a loud voice. For          A lethargic patient appears drowsy but
              example, call the patient’s name or ask, “How      opens the eyes and looks at you, responds
              are you?”                                          to questions, and then falls asleep.
Obtundation   Shake the patient gently, as if awakening a        An obtunded patient opens the eyes and
              sleeper.                                           looks at you, but responds slowly and is
                                                                 somewhat confused. Alertness and interest
                                                                 in the environment are decreased.
Stupor        Apply a painful stimulus. For example, pinch a     A stuporous patient arouses from sleep
              tendon, rub the sternum, or roll a pencil across   only after painful stimuli. Verbal responses
              a nail bed. (No stronger stimuli are needed.)      are slow or even absent. The patient
                                                                 lapses into an unresponsive state when
                                                                 the stimulus ceases. There is minimal
                                                                 awareness of self or the environment.
Coma          Apply repeated painful stimuli.                    A comatose patient remains unarousable
                                                                 with eyes closed. There is no evident
                                                                 response to inner need or external stimuli.
Glasgow Coma Scale
Trophic changes or deformities

                     Speech
Read Sorat El Fateha
• Aphasia: (higher neurolo. center lesion):
• Dysarthria: (articul system or Cr n. lesion):
Motor
          •   Involuntary: extra ∆ , fasiculation
          •   State
          •   Tone                            •Dist or prox
                                              •Stat or Kinetic
          •   Weakness                        •Disappear e sleep or Not

          •   Ataxia (cerebellum)
          •   Reflexes              •UL or LL
                                                •Rt or Lt
•Rapid alternating movem
•Drunken gait              Sensory or           •Dist or Prox
•Finger-to-Nose /Finger
•Intension tremors         Cerebellar ataxia:   •Flexor or Extensor
•Heel-to-Knee
•dysdidoko Test                                 •Abductor or Adductor
•Romberg’s Test
•+ve romberge              •-ve romberg
•Gait
•Improve on bed            •Intension tremors
Tone
• 6 joints + don’t forget support before joint
• Tone is the resistance appreciated when
      moving a limb passively
• “Normal Tone”
• Hypotonia
  – “Central Hypotonia”:shock UMNL, cerebellar
  – “Peripheral Hypotonia”: LMNL, myopathy
• Hypertonia
  – Spasticity (Corticospinal Tract = ∆ )
  – Rigidity (Basal Ganglia, Parkinson’s = extra ∆ )
Weakness: examine the following
Flexion at the elbow (C5, C6, biceps)
Extension at the elbow (C6, C7, C8, triceps)
Extension at the wrist (C6, C7, C8, radial nerve)
Squeeze 2 fingers as hard as possible ("grip," C7, C8, T1)
Finger abduction (C8, T1, ulnar nerve)
Oppostion of the thumb (C8, T1, median nerve)
Flexion at the hip (L2, L3, L4, iliopsoas)
Adduction at the hips (L2, L3, L4, adductors)
Abduction at the hips (L4, L5, S1, G. medius and minimus)
Extension at the hips (S1, gluteus maximus)
Extension at the knee (L2, L3, L4, quadriceps)
Flexion at the knee (L4, L5, S1, S2, hamstrings)
Dorsiflexion at the ankle (L4, L5)
Plantar flexion (S1)
Weakness: examine the following
Muscle(s)             Function              Primary Nerve Origin
DELTOID               Shoulder abduction    Axillary           C5-C6
BICEPS                Elbow flexion         Musculocutaneous   C5, C6
TRICEPS               Elbow extension       Radial             C6, C7, C8
WRIST EXTENSORS                             Radial             C6, C7, C8
WRIST FLEXION                               Median             C6, C7
HAND GRIP             Grasp Fingers         Median             C7, C8, T1
FINGER ADDUCTION                            Median             C7-T1
FINGER ABDUCTION                            Ulnar              C8, T1
THUMB OPPOSITION                            Median             C8, T1
HIP FLEXION                                 Iliopsoas          L2, L3, L4
HIP EXTENSION                               Gluteus maximus    S1
Quadriceps            Knee extension                           L2, L3, L4
Hamstrings            Knee flexion                             L4, L5, S1, S2
Tibialis anterior     Foot dorsiflexion     Deep peroneal      L4, L5
Gastrocnemius         Ankle plantar flex                       mainly S1
Ext hallicus longus   Extens of great toe                      L5
Weakness: examine the following
Upper limb:             C8                              Lower limb:
C4
C5
     Shoulder:          T1   Hand                          Hip:
        Adduction             Thumb                              Flexion     L1,2
        Abduction              Oppon pollicis           L5, S1   Extension
        Flexion                Abd pollicis                      Adduction
        Extension              Add pollicis                      Abduction
        Lat rotation
        Med rotation
                                Flexor pollicis             Knee:
                                Exte pollicis            S1,2     Flexion
        serratus ant.
C5                            Other fingers:                      Extension   L2,3,4
C6   Elbow:                    Abductors
C7
        Flexion                                             Ankle:
                                Adductors
        Extension                                                 Dorsiflexion L4,5
                                Flexion                  S1,2     Planter flexion
C7
C8
     Wrist:                    Extension
        Flexion                Lumbricalis
        Extension

                         Abdom. mus:              T7-
                                                   T12
                                                         Trunk mus:
                                Flexion                           extension
Grading Motor Strength
      Grade                           Description
0/5           No muscle movement

1/5           Visible muscle movement, but no movement at the joint

2/5           Movement at the joint, but not against gravity

3/5           Movement against gravity, but not against added resistance

4/5           Movement against resistance, but less than normal

5/5           Normal strength
Reflexes & clonus
Deep (tendon jerks)                            Superficial reflexes
   UL                                                        •    Corneal
   C5,6
               • BICEPS                                       •    Grasp
               • BRACHIORADIALIS                              •    Gag (palatal)
  C6,7         • TRICEPS                             S1,2     •    Planter
                                     Sure
   LL                             signs of          T6-12    •    Abdominal
                                    ∆????            L1
  L2,3,4       • KNEE + clonus                                •    Cremastric
  S1,2         • ANKLE + clonus                      S3,4,5   •    Anal
                                                                            Technique
Abnormal Deep reflexes                  Babiniski     Scratsh From below up- lat to medial
                                         Chaddock      The skin under and around the lateral malleolus
           •   Jaw jerk                                is stroked in a circular fashion.
           •   Wartenberg                Gonda’s
                                                              rd    th
                                                   Flex 3 & 4 toes 7 release suddenly
                                         Oppenheim press to the anterior surface of the tibia,
           •   Finger jerk                         stroking down to the ankle.
           •   Hofman                    Gordon        Compressing the calf muscles

           •   Patelal jerk              Schaefer      Pinching the Achilles tendon enough to cause
                                                       pain.
           •   Adductor jerk
EXAMINATION – REFLEXES: SCALE
       FOR GRADING
Reflexes are usually graded on a 0 to 4+ scale
4+ Very brisk, hyperactive, with clonus
3+ Brisker than average; possibly but not
   necessarily indicative of disease (no clonus)
2+ Average; normal
1+ Somewhat diminished; low normal
0   No response
Sensory
• Superficial: Pain, Temp, Touch (one ⅟2, Rt & Lt, derm)
• Deep: Position, Mov., Vibr., N & M          If +ve : pattern
                                                    •Sensory level
• Cortical: Steriog, T. loc & discr., Graph.        •hemihypoth
                                                       •Glove & stock
                                                       •Jacket loss
Cranial n
• ① - smell
• ② - Acuity: ( Snellen chart, Counting finger, Hand
   mov., Light perception)
          - Fields ( confrontation)
          - Fundus
          - Colour vision
• ③,④,⑥- Ocular mov.
  Partial ptosis+  - Ptosis, Myosis or Mydriasis
                                                 Complete ptosis+
     Miosis+       - Reflexes:                     Mydriasis+
  Anhdrosis+
  Enophthalm         • Light: (direct & consensual)   Diverg squint
                     • Accomodation                         =
      =
                                                           ??
      ??             • Ciliospinal
Cranial n
• ⑤ - Sensory: (ophth., maxillary, mandibular)
    - Motor: (massiter, temporalis, tregoid)
    - Reflexes:
     →
            • Corneal
     →      • Jaw : if +ve = bilateral ∆ lesion above pons (above   nc.)
•        - Sensory: (Tast ant ⅔ of tounge)
         - Motor: (frontalis, orbic occul., buccinator,
           retractor angulii, orbic oris)
         - Reflexes:             Rapid phase toward
           →    • glabellar   occular   pendular            H
• ⑧ - Nystagmus               cerebel   fix i.e. (lesion)   H
                              vestib    Away from (norm) H
    - Hearing
                              stem      vertical            V
Cranial n
• ⑨,⑩ -Say AHH = palatal movement

          Move                                        No movement

                                               →
                                                   -Palat reflex
                        deviate to healthy =
Move up = normal
                                LMNL           →   -Pharyn reflex


         Exag bilat=                                   Lost bilateral=
       Bilateral UMNL                                  Bilateral LMNL
Cranial n
• ⑪ - Shoulder elev (trapezius)
    - Neck side mov (sternomastoid)

• ⑫ - Observation ( atrophy, fascic)
    - Midline protrusion (Deviation, invol. movem )
    - Power

                     Sphincters
                         ↑ ICT
Gait
Classical Patterns of Abnormal Gait
   •Parkinsonism Gait
   •Hemiparetic Gait
   •Ataxia Gait
   •Waddling Gait (Hip Girdle Weakness)
   •High Stepping Gait


      Other systems affection
NEUROLOGICAL EXAMINATION GUIDE

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NEUROLOGICAL EXAMINATION GUIDE

  • 1. NEUROLOGICAL EXAMINATION Dr Ahmed Youssef Lecturer of internal medicine & nephrology
  • 2. History • Personal H: • Past H: – Handness 2T Trauma, TB – Occupation (driver) 2S Syphilis, Similar attack 2H HTN, Heart disease • C/O: 2D DM, Drugs – Onset, course & duration 1E ENT 1F Fever • Family H: – Heredofamilial ataxia – Familial periodic paralysis • HPI: – Peroneal mus. atrophy – 12 items
  • 3. HPI • Motor • Cranial n • Speech • Mental • Sensory • ↑ ICT • Sphincter • Hypoth • Trophic • Fits • Gait • Other
  • 4. Motor • Involuntary: extra ∆ , fasiculation • State • Tone •Dist or prox •Stat or Kinetic • Weakness •Disappear e sleep or Not • Ataxia (cerebellum) •UL or LL •Drunken gait •Rt or Lt •Intension tremors •Dist or Prox •dysdidoko •Flexor or Extensor •+ve romberge •Abductor or Adductor •Improve on bed
  • 5. Sensory • Superficial: Pain, Temp, Touch • Deep: Position, Mov., Vibr. If +ve : pattern •Sensory level • Cortical: Steriog, T. loc., T. discr. •hemihypoth •Glove & stock •Jacket loss Trophic changes or deformities • Ulcers: (N.B. : painless)
  • 6. • ①: Cranial n • Anosmia • : • , : • Sensory • • ②: • Tast ant ⅔ Dysph (phar) • Acuity • N. regur (palat) • Motor • Field • N. tone (palat) • Eey clos. • Mouth clos. • Hoarsn (lary) • ③,④,⑥: • Diplopia • : • : • Ptosis • Deaf • Shoulder elev • Squint • Tinitus • neck side mov • Vertigo • ⑤: • : • Sensory • Tounge mov • Pain,Temp • Motor • Masticat.
  • 7. ↑ ICT • Papilledema • Headache • Vomiting Fits • Aura • Post effect • Cons. Loss • Gener. Or local • March
  • 8. Speech • Aphasia: (higher neurolo. center lesion): – Receptive(sensory): • Spoken(Auditory)(aud recogn area lesion) • Written(Visual)(visual recogn area lesion) – Expressive(motor): • Spoken (broca’s area lesion) • Written(Agraphia)(exner’s area lesion) • Dysarthria: (articul system lesion): – ∆: bilateral→ slurred (psudobulbar) – Extra ∆ → slow monotonus – Cerebellar → stacatto – Cr n → slurred (true bulbar)
  • 9. Sphincters Gait Mental • Consciousness • Hallucination • Memory
  • 10. Hypothalamus • D.I. • Polyphagia • Hypogonadal • Hypersomnia • Hyperpyrexia Other systems affection
  • 11. Examination • General examination • Neurological examination: • Motor • Cranial n • Speech • Mental • Sensory • ↑ ICT • Sphincter • Hypoth • Trophic • Fits • Gait • Other
  • 12. Mental • Consciousness • Memory • Mode • Orientation • Behavior • Intelligence
  • 13. EXAMINATION – LEVEL OF CONSCIOUSNESS (AROUSAL) Level of Consciousness (Arousal): Techniques and Patient Response Level Technique Abnormal Response Alertness Speak to the patient in a normal tone of voice. An alert patient opens the eyes, looks at you, and responds fully and appropriately to stimuli (arousal intact). Lethargy Speak to the patient in a loud voice. For A lethargic patient appears drowsy but example, call the patient’s name or ask, “How opens the eyes and looks at you, responds are you?” to questions, and then falls asleep. Obtundation Shake the patient gently, as if awakening a An obtunded patient opens the eyes and sleeper. looks at you, but responds slowly and is somewhat confused. Alertness and interest in the environment are decreased. Stupor Apply a painful stimulus. For example, pinch a A stuporous patient arouses from sleep tendon, rub the sternum, or roll a pencil across only after painful stimuli. Verbal responses a nail bed. (No stronger stimuli are needed.) are slow or even absent. The patient lapses into an unresponsive state when the stimulus ceases. There is minimal awareness of self or the environment. Coma Apply repeated painful stimuli. A comatose patient remains unarousable with eyes closed. There is no evident response to inner need or external stimuli.
  • 15. Trophic changes or deformities Speech Read Sorat El Fateha • Aphasia: (higher neurolo. center lesion): • Dysarthria: (articul system or Cr n. lesion):
  • 16. Motor • Involuntary: extra ∆ , fasiculation • State • Tone •Dist or prox •Stat or Kinetic • Weakness •Disappear e sleep or Not • Ataxia (cerebellum) • Reflexes •UL or LL •Rt or Lt •Rapid alternating movem •Drunken gait Sensory or •Dist or Prox •Finger-to-Nose /Finger •Intension tremors Cerebellar ataxia: •Flexor or Extensor •Heel-to-Knee •dysdidoko Test •Abductor or Adductor •Romberg’s Test •+ve romberge •-ve romberg •Gait •Improve on bed •Intension tremors
  • 17. Tone • 6 joints + don’t forget support before joint • Tone is the resistance appreciated when moving a limb passively • “Normal Tone” • Hypotonia – “Central Hypotonia”:shock UMNL, cerebellar – “Peripheral Hypotonia”: LMNL, myopathy • Hypertonia – Spasticity (Corticospinal Tract = ∆ ) – Rigidity (Basal Ganglia, Parkinson’s = extra ∆ )
  • 18. Weakness: examine the following Flexion at the elbow (C5, C6, biceps) Extension at the elbow (C6, C7, C8, triceps) Extension at the wrist (C6, C7, C8, radial nerve) Squeeze 2 fingers as hard as possible ("grip," C7, C8, T1) Finger abduction (C8, T1, ulnar nerve) Oppostion of the thumb (C8, T1, median nerve) Flexion at the hip (L2, L3, L4, iliopsoas) Adduction at the hips (L2, L3, L4, adductors) Abduction at the hips (L4, L5, S1, G. medius and minimus) Extension at the hips (S1, gluteus maximus) Extension at the knee (L2, L3, L4, quadriceps) Flexion at the knee (L4, L5, S1, S2, hamstrings) Dorsiflexion at the ankle (L4, L5) Plantar flexion (S1)
  • 19. Weakness: examine the following Muscle(s) Function Primary Nerve Origin DELTOID Shoulder abduction Axillary C5-C6 BICEPS Elbow flexion Musculocutaneous C5, C6 TRICEPS Elbow extension Radial C6, C7, C8 WRIST EXTENSORS Radial C6, C7, C8 WRIST FLEXION Median C6, C7 HAND GRIP Grasp Fingers Median C7, C8, T1 FINGER ADDUCTION Median C7-T1 FINGER ABDUCTION Ulnar C8, T1 THUMB OPPOSITION Median C8, T1 HIP FLEXION Iliopsoas L2, L3, L4 HIP EXTENSION Gluteus maximus S1 Quadriceps Knee extension L2, L3, L4 Hamstrings Knee flexion L4, L5, S1, S2 Tibialis anterior Foot dorsiflexion Deep peroneal L4, L5 Gastrocnemius Ankle plantar flex mainly S1 Ext hallicus longus Extens of great toe L5
  • 20. Weakness: examine the following Upper limb: C8 Lower limb: C4 C5 Shoulder: T1 Hand Hip: Adduction Thumb Flexion L1,2 Abduction Oppon pollicis L5, S1 Extension Flexion Abd pollicis Adduction Extension Add pollicis Abduction Lat rotation Med rotation Flexor pollicis Knee: Exte pollicis S1,2 Flexion serratus ant. C5 Other fingers: Extension L2,3,4 C6 Elbow: Abductors C7 Flexion Ankle: Adductors Extension Dorsiflexion L4,5 Flexion S1,2 Planter flexion C7 C8 Wrist: Extension Flexion Lumbricalis Extension Abdom. mus: T7- T12 Trunk mus: Flexion extension
  • 21. Grading Motor Strength Grade Description 0/5 No muscle movement 1/5 Visible muscle movement, but no movement at the joint 2/5 Movement at the joint, but not against gravity 3/5 Movement against gravity, but not against added resistance 4/5 Movement against resistance, but less than normal 5/5 Normal strength
  • 22. Reflexes & clonus Deep (tendon jerks) Superficial reflexes UL • Corneal C5,6 • BICEPS • Grasp • BRACHIORADIALIS • Gag (palatal) C6,7 • TRICEPS S1,2 • Planter Sure LL signs of T6-12 • Abdominal ∆???? L1 L2,3,4 • KNEE + clonus • Cremastric S1,2 • ANKLE + clonus S3,4,5 • Anal Technique Abnormal Deep reflexes Babiniski Scratsh From below up- lat to medial Chaddock The skin under and around the lateral malleolus • Jaw jerk is stroked in a circular fashion. • Wartenberg Gonda’s rd th Flex 3 & 4 toes 7 release suddenly Oppenheim press to the anterior surface of the tibia, • Finger jerk stroking down to the ankle. • Hofman Gordon Compressing the calf muscles • Patelal jerk Schaefer Pinching the Achilles tendon enough to cause pain. • Adductor jerk
  • 23. EXAMINATION – REFLEXES: SCALE FOR GRADING Reflexes are usually graded on a 0 to 4+ scale 4+ Very brisk, hyperactive, with clonus 3+ Brisker than average; possibly but not necessarily indicative of disease (no clonus) 2+ Average; normal 1+ Somewhat diminished; low normal 0 No response
  • 24. Sensory • Superficial: Pain, Temp, Touch (one ⅟2, Rt & Lt, derm) • Deep: Position, Mov., Vibr., N & M If +ve : pattern •Sensory level • Cortical: Steriog, T. loc & discr., Graph. •hemihypoth •Glove & stock •Jacket loss
  • 25. Cranial n • ① - smell • ② - Acuity: ( Snellen chart, Counting finger, Hand mov., Light perception) - Fields ( confrontation) - Fundus - Colour vision • ③,④,⑥- Ocular mov. Partial ptosis+ - Ptosis, Myosis or Mydriasis Complete ptosis+ Miosis+ - Reflexes: Mydriasis+ Anhdrosis+ Enophthalm • Light: (direct & consensual) Diverg squint • Accomodation = = ?? ?? • Ciliospinal
  • 26. Cranial n • ⑤ - Sensory: (ophth., maxillary, mandibular) - Motor: (massiter, temporalis, tregoid) - Reflexes: → • Corneal → • Jaw : if +ve = bilateral ∆ lesion above pons (above nc.) • - Sensory: (Tast ant ⅔ of tounge) - Motor: (frontalis, orbic occul., buccinator, retractor angulii, orbic oris) - Reflexes: Rapid phase toward → • glabellar occular pendular H • ⑧ - Nystagmus cerebel fix i.e. (lesion) H vestib Away from (norm) H - Hearing stem vertical V
  • 27. Cranial n • ⑨,⑩ -Say AHH = palatal movement Move No movement → -Palat reflex deviate to healthy = Move up = normal LMNL → -Pharyn reflex Exag bilat= Lost bilateral= Bilateral UMNL Bilateral LMNL
  • 28. Cranial n • ⑪ - Shoulder elev (trapezius) - Neck side mov (sternomastoid) • ⑫ - Observation ( atrophy, fascic) - Midline protrusion (Deviation, invol. movem ) - Power Sphincters ↑ ICT
  • 29. Gait Classical Patterns of Abnormal Gait •Parkinsonism Gait •Hemiparetic Gait •Ataxia Gait •Waddling Gait (Hip Girdle Weakness) •High Stepping Gait Other systems affection