A presentation about Coenzyme Q10

1. Muhammad Aiyaz Sharif
Product Manager
PharmEvo Pvt. Ltd

2. What is Co-enzyme Q10?
Coenzyme Q10, also known as ubiquinone, coenzyme Q, and
abbreviated at times to CoQ10 .
This oil-soluble, vitamin-like substance is present in most
eukaryotic cells, primarily in the mitochondria.
It is a component of the electron transport chain and
participates in aerobic cellular respiration, generating
energy in the form of ATP.
Ninety-five percent of the human body’s energy is
generated this way.1,2
1.Ernster, L; Dallner, G (1995). "Biochemical, physiological and medical aspects of ubiquinone function". Biochimica et
Biophysica Acta 1271 (1): 195–204.
2.Dutton, PL; Ohnishi, T; Darrouzet, E; Leonard, MA; Sharp, RE; Cibney, BR; Daldal, F; Moser, CC (2000). "4 Coenzyme Q
oxidation reduction reactions in mitochondrial electron transport". In Kagan, VE; Quinn, PJ. Coenzyme Q: Molecular
mechanisms in health and disease. Boca Raton: CRC Press. pp. 65–82

3. Who discovered it?
CoQ10 was first discovered by Professor Fredrick L. Crane
and colleagues at the University of Wisconsin–Madison
Enzyme Institute in 1957.3,4
In 1958, its chemical structure was reported by Dr. Karl
Folkers and coworkers at Merck.
In 1961 Peter Mitchell proposed the electron transport
chain (which includes the vital proton motive role of CoQ10)
and he received a Nobel Prize for the same in 1978.
3.Crane, F; Hatefi, Y; Lester, R; Widmer, C (1957). "Isolation of a quinone from beef heart mitochondria".
Biochimica et Biophysica Acta 25 (1): 220–1
4.Peter H. Langsjoen,"Introduction of Coezyme Q10“

4. WWhhaatt iiss tthhee rroollee ooff NNeeooQQ1100

5. How is it synthesized?
Starting from acetyl-CoA, a
multistep process of mevalonate
pathway produces farnesyl-PP
(FPP), the precursor for
cholesterol and CoQ10.

6. CCaauusseess ooff CCooQQ1100 ddeeccrreeaassee
1. Age Dependent Decrease.
2. Use Of Statin.

8. WWhhyy uussee aalloonngg wwiitthh ssttaattiinn??
So reduction in cholesterol
leads to reduction in CoQ10
which results in myalgia and
reduced cardio protection
Statin Use
Add What to do?

9. PPhhaarrmmaaccookkiinneettiiccss
Absorption:
Following ingestion of 100 mg of CoQ, peak
plasma levels occur between 5 and 10 hours.
T max is approximately 6.5 hours

10. PPhhaarrmmaaccookkiinneettiiccss
Distribution:
The plasma half-life of CoQ in different tissues
varies between 49-125 hours.
Following absorption from the GI tract, CoQ is
taken up by chylomicrons. The major portion of
an exogenous dose of CoQ is deposited in the
liver and packaged into VLDL lipoprotein.

11. PPhhaarrmmaaccooddyynnaammiiccss
Metabolism/Excretion:
It is assumed that metabolism and excretion of
exogenous CoQ is analogous to endogenously
produced CoQ. The excretion of CoQ is
predominantly via the biliary tract.

12. PPhhaarrmmaaccooddyynnaammiiccss
Drug interaction:
Warfarin: CoQ may antagonize the effects of
warfarin. CoQ is structurally similar to vitamin K.
Chemotherapy: Theoretically, CoQ may
decrease the efficacy of chemotherapy due to
antioxidant activity.

13. DDoossaaggee aanndd IInnddiiccaattiioonn
DDoossaaggee::
• One capsule twice daily.
IInnddiiccaattiioonn::
• Statin Induced Myalgia.
• Age dependent depletion of CO-Q10.
• In Patients with major cardiovascular events.
• Chronic Fatigue syndrome

14. Clinical Studies

17. Am J Clin Nutr 2013;97:233–4

19. CCeellll NNuummbbeerr:: 00333333--22229922223311

21. CCoonncclluussiioonn
These patients, steadily worsening and expected to die
within 2 years under conventional therapy, generally
showed an extraordinary clinical improvement, indicating
that CoQ10 therapy might extend the lives of such patients.
This improvement could be due to correction of a
myocardial deficiency of CoQ10 and to enhanced synthesis
of CoQ10-requiring enzymes.

22. Response of patients in classes III and IV of cardiomyopathy to
therapy in a blind and crossover trial with coenzyme Q10
Proc. Nati. Acad. Sci. USA
Vol. 82, pp. 4240-4244, June 1985
Medical Sciences
A double-blind and double-crossover trial has been
conducted by administering CoQ10 and a matching placebo
orally to two groups of patients having class I or IV
cardiomyopathy (classification according to criteria of the
New York Heart Association).
Group A received CoQ10 and then placebo; group B
received placebo and then CoQ10. Blood levels of CoQ1o
and cardiac function were determined at 0 and 4 weeks
(control stabilization period) and at 16 and 28 weeks (after
the 12-week CoQ/placebo-treatment periods).

23. RReessuullttss
• For group A, significant increases in CoQ10 blood levels
and cardiac function (SV and EF) occurred during CoQ10
treatment and then decreased during crossover to
placebo.
• For group B, there was no change in CoQ10 blood levels
and cardiac function (SV and EF) during placebo
treatment, but increases in both parameters occurred in
crossover to CoQ10