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DNA COMPUTING
Presented by:~
Abhiroop Roy Chowdhury
Aditi Roy
Affan Ahmed
Amit Singh
Ananya Roy
Aniket Biswas
Anirban Nag
 Little about DNA & DNA Computing
 Logical Operations in DNA Computer
 Adleman’s Hamiltonian path solution
 DNA chips vs. Silicon chips
 Advantages
 Application & limitations
 Future Prospects
 Conclusion
GNIT, IT, 3RD YEAR
 Double stranded helical staircase
structure
 Adenine (A) + Thymine (T)
Guanine (G) + Cytosine (C)
 Biological technique as efficient
computing vehicle
 Data are represented using strands of
DNA
GNIT, IT, 3RD YEAR
INTRODUCTION
 Logical operators AND, OR, NOT = DNA
cutting, copying, pasting
 Enzymes function simultaneously
 Massive parallelism
GNIT, IT, 3RD YEAR
DNA chips VS Silicon chips
DNA chips
• Parallel processing
• Increased memory
capacity=>better
performance
• cheap due to easy
availabilty
Silicon chips
• Sequential processing
• Increased CPU
speed=>better performance
• Relatively costlier
GNIT, IT, 3RD YEAR
 A directed graph with N vertices and E edges
 A fixed start(S ) and target(T ) vertex
 A path from S to T
 With no vertex repeating
 Having exactly N vertices
GNIT, IT, 3RD YEAR
HAMILTONIAN PATH PROBLEM
S
T
GNIT, IT, 3RD YEAR
1. Generate Random paths
GNIT, IT, 3RD YEAR
ALGORITHM
GNIT, IT, 3RD YEAR
2. Keep paths starts from S to T
3. Keep only those that visit exactly N vertices
Contd..
GNIT, IT, 3RD YEAR
4. Keep only those that visit each vertex only once
5. If any DNA sequence remains then a path exists
6. Otherwise no path exist
Contd..
 Cellular organisms  Supply of DNA.
 Large supply of DNA - Cheap resource
 DNA performs error correction
 Smaller than today's computers, large
storage
GNIT, IT, 3RD YEAR
ADVANTAGES
GNIT, IT, 3RD YEAR
ADVANTAGES
1 gram of DNA =
 DNA Fingerprinting
 Pharmaceutical Applications
 Adleman’s experiment took over 7 days to end
 The experiment will fail for 200 or more cities
GNIT, IT, 3RD YEAR
APPLICATIONS & LIMITATIONS
 IBM seeks a fusion of DNA & Silicon
 Biologists are researching implementation of DNA
Computer to human cells
 ‘killer app’-domain of
DNA2DNA application
GNIT, IT, 3RD YEAR
FUTURE PROSPECTS
GNIT, IT, 3RD YEAR
o logical game development– Tic-Tac-Toe
o Cryptography
o Planning efficient airline routes
o Helps in implementing molecular
computation
CONCLUSION
[1] Intelligent Computing Everywhere Schuster, Alfons (Ed.), ISBN 978-1-
84628-943-9,2007
[2] Adleman, L. M. (1994). "Molecular computation of solutions to
combinatorial problems". Science 266 (5187): 1021–1024
[3] www.cdn-5.freeclipartnow.com
[4] www.idmarching.com
[5] NPTEL Videos
GNIT, IT, 3RD YEAR
References

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DNA Computing: Logical Operations, Adleman's Solution & Future Prospects

  • 1. DNA COMPUTING Presented by:~ Abhiroop Roy Chowdhury Aditi Roy Affan Ahmed Amit Singh Ananya Roy Aniket Biswas Anirban Nag
  • 2.  Little about DNA & DNA Computing  Logical Operations in DNA Computer  Adleman’s Hamiltonian path solution  DNA chips vs. Silicon chips  Advantages  Application & limitations  Future Prospects  Conclusion GNIT, IT, 3RD YEAR
  • 3.  Double stranded helical staircase structure  Adenine (A) + Thymine (T) Guanine (G) + Cytosine (C)  Biological technique as efficient computing vehicle  Data are represented using strands of DNA GNIT, IT, 3RD YEAR INTRODUCTION
  • 4.  Logical operators AND, OR, NOT = DNA cutting, copying, pasting  Enzymes function simultaneously  Massive parallelism GNIT, IT, 3RD YEAR
  • 5. DNA chips VS Silicon chips DNA chips • Parallel processing • Increased memory capacity=>better performance • cheap due to easy availabilty Silicon chips • Sequential processing • Increased CPU speed=>better performance • Relatively costlier GNIT, IT, 3RD YEAR
  • 6.  A directed graph with N vertices and E edges  A fixed start(S ) and target(T ) vertex  A path from S to T  With no vertex repeating  Having exactly N vertices GNIT, IT, 3RD YEAR HAMILTONIAN PATH PROBLEM S T
  • 8. 1. Generate Random paths GNIT, IT, 3RD YEAR ALGORITHM
  • 9. GNIT, IT, 3RD YEAR 2. Keep paths starts from S to T 3. Keep only those that visit exactly N vertices Contd..
  • 10. GNIT, IT, 3RD YEAR 4. Keep only those that visit each vertex only once 5. If any DNA sequence remains then a path exists 6. Otherwise no path exist Contd..
  • 11.  Cellular organisms  Supply of DNA.  Large supply of DNA - Cheap resource  DNA performs error correction  Smaller than today's computers, large storage GNIT, IT, 3RD YEAR ADVANTAGES
  • 12. GNIT, IT, 3RD YEAR ADVANTAGES 1 gram of DNA =
  • 13.  DNA Fingerprinting  Pharmaceutical Applications  Adleman’s experiment took over 7 days to end  The experiment will fail for 200 or more cities GNIT, IT, 3RD YEAR APPLICATIONS & LIMITATIONS
  • 14.  IBM seeks a fusion of DNA & Silicon  Biologists are researching implementation of DNA Computer to human cells  ‘killer app’-domain of DNA2DNA application GNIT, IT, 3RD YEAR FUTURE PROSPECTS
  • 15. GNIT, IT, 3RD YEAR o logical game development– Tic-Tac-Toe o Cryptography o Planning efficient airline routes o Helps in implementing molecular computation CONCLUSION
  • 16. [1] Intelligent Computing Everywhere Schuster, Alfons (Ed.), ISBN 978-1- 84628-943-9,2007 [2] Adleman, L. M. (1994). "Molecular computation of solutions to combinatorial problems". Science 266 (5187): 1021–1024 [3] www.cdn-5.freeclipartnow.com [4] www.idmarching.com [5] NPTEL Videos GNIT, IT, 3RD YEAR References