Hemoglobin & Anemias - the basics by Dr.M.Anthony David MD

ERYTHROCYTES, HEMOGLOBIN & ANEMIAS By Dr.M.Anthony David MD Professor of Physiology NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],[object Object]

POLYCYTHEMIA ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

ERYTHROCYTE MORPHOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

HEMOGLOBIN ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

HEMOGLOBIN MOLECULE NOMAD:2006: BP: HBANEM

SYNTHESIS OF HEMOGLOBIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

HEME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

HEMOGLOBIN CATABOLISM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],HEMOGLOBIN CATABOLISM NOMAD:2006: BP: HBANEM

HEMOGLOBIN:NORMAL LEVELS ,[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],[object Object],HEMOGLOBIN LEVELS : SIGNIFICANCE NOMAD:2006: BP: HBANEM

HEMOGLOBIN FORMATION: FACTORS ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],HEMOGLOBIN FORMATION: FACTORS NOMAD:2006: BP: HBANEM

HEMOGLOBIN: STRUCTURE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

STRUCTURE & FUNCTION ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],[object Object],STRUCTURE & FUNCTION NOMAD:2006: BP: HBANEM

HEMOGLOBIN: VARIETIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

Hb:PHYSIOLOGICAL VARIETIES ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

Hb: PATHOLOGICAL : SICKLE CELL DISEASE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

SICKLE CELL DISEASE ,[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

A SICKLED ERYTHROCYTE NOMAD:2006: BP: HBANEM

Hb: PATHOLOGICAL : THALASSEMIAS ,[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

BETA THALASSEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

NOMAD:2006: BP: HBANEM Let's take a break!

NOMAD:2006: BP: HBANEM BACK TO WORK NOW!

IRON METABOLISM & ANEMIAS By Dr.M.ANTHONY DAVID, MD Professor of Physiology NOMAD:2006: BP: HBANEM

IRON IN THE BODY NOMAD:2006: BP: HBANEM BIOCHEMICAL FORM SITE CONC. % OF TOTAL HEMOGLOBIN Erythrocytes 2.5 Gms 60-65 STORAGE Fe (ferritin & hemosiderin) Phagocytes & Hepatic Parenchymal cells 1 – 1.5 Gms 25 -30 MYOGLOBIN Myohemoglobin Red Muscle Fibres 0.2 Gms 150-200mg 4 Trace Heme Tissue enzymes Tissue Cells < 0.1 Gms 1

IRON BALANCE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IRON BALANCE: women NOMAD:2006: BP: HBANEM

IRON ABSORPTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

ANEMIAS Deficiency of Hb in the blood caused by either:  RBC Count or  Hb in the RBCs NOMAD:2006: BP: HBANEM

ANEMIAS: CLASSIFICATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

1. HEMORRHAGIC ANEMIA (BLOOD LOSS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

2. APLASTIC ANEMIA: ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

3. MEGALOBLASTIC ANEMIA: ,[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

MEGALOBLASTIC ANEMIA: ,[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

NOMAD:2006: BP: HBANEM MEGALOBLASTS

4. HEMOLYTIC ANEMIAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

5. SICKLE CELL ANEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

ERYTHROBLASTOSIS FETALIS ,[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

IRON DEFICIENCY ANEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

IRON RICH DIETS NOMAD:2006: BP: HBANEM

SECONDARY ANEMIA(RENAL) ,[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

REVIEW ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

REVIEW ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],REVIEW NOMAD:2006: BP: HBANEM

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],REVIEW NOMAD:2006: BP: HBANEM

NOMAD:2006: BP: HBANEM THANKS FOR LISTENING!

Hemoglobin & Anemias - the basics by Dr.M.Anthony David MD

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Hemoglobin & Anemias - the basics by Dr.M.Anthony David MD