Mishima.syk#13の発表資料

6.
Chen S, 2015

7. Togo picture gallery by DBCLS is Licensed
under a Creative Commons 2.1 (c)

9.
Pavilicev M, 2017
Ramilowski J A, 2015
Li L, 2017
Skelly D A, 2018

10. Togo picture gallery by DBCLS is Licensed
under a Creative Commons 2.1 (c)

13. X

14. X X1 X2 X3
^ ^ ^

15. X
u1'◦v1' u2'◦v2' u3'◦v3'
X1 X2 X3
^ ^ ^

16. X
u1'◦v1' u2'◦v2' u3'◦v3'
u1◦v1 u2◦v2 u3◦v3
X1 X2 X3
^ ^ ^
λ1 λ2 λ3

17. X
u1'◦v1' u2'◦v2' u3'◦v3'
u1◦v1 u2◦v2 u3◦v3
UΛVT
X1 X2 X3
^ ^ ^
λ1 λ2 λ3

18. χ
A(1)
A(2)
A(3)
S

19. χ
S
S

21. 1
Tsuyuzaki K. et. al.,
2019 (in prep.)

22. 2
Tsuyuzaki K. et. al.,
2019 (in prep.)

23. 3
Tsuyuzaki K. et. al.,
2019 (in prep.)

24. 4
Tsuyuzaki K. et. al.,
2019 (in prep.)

26. library(scTensor)
library(SingleCellExperiment)
library(LRBase.Hsa.eg.db)
data(“GermMale”) # Data matrix (486genes × 852cells, 7class, 3.5MB)
data(“tsneGermMale”) # The result of Rtsne (21kb)
data(“labelGermMale”) # Celltype label (15kb)
sce <- SingleCellExperiment(assays = list(counts = GermMale))
reducedDims(sce) <- SimpleList(TSNE = tsneGermMale$Y)
cellCellSetting(sce, LRBase.Hsa.eg.db, labelGermMale, names(labelGermMale))
rks <- cellCellRanks(sce)
cellCellDecomp(sce, ranks=rks$selected)
cellCellReport(sce, reducedDimNames="TSNE", out.dir=tmp,
title="Cell-cell interaction within Germline, Male, GSE86146",
author="Koki Tsuyuzaki", thr=80)

30. Tsuyuzaki K. et. al., 2018

33.
Tsuyuzaki K. et. al., 2018

34.
1/4

35.
1/4
Himmelstein, D S et al., 2017

36.
2/4

37. 2/4
Cichonska, A et al., 2015

38. 3/4

39. 3/4
Gusev A. et. al., 2016Sun S. et. al., 2018

40. 4/4

41. 4/4
Butler A et. al., 2018Brown B C et. al., 2018

43. =
Raquel Urtasun, 2008Laurens, 2008
Graph PCA, Bo Jiang, 2013

44. PCA: 1 X

45. PLS/CCA/siNMF: 2 X,Y

46. PLS/CCA/siNMF: 2 X,Y

47. PLS/CCA/siNMF: 2 X,Y

48. CMF: n
Marinka Zitnik, 2016

49. CMTF: n
Ermis B, 2012
Suleiman A Khan, 2016
Evirm Acar, 2011