Apply gentle pressure proximally
Surgeon: Check distal pulses and capillary refill
If no improvement:
Consider temporary arteriotomy or venous shunt
Delay closure and observe
Flap or graft may be needed
2. Introduction
• In 1831,Baron Guillaume Dupuytren
described the condition of palmar
fascial contraction (Dupuytren disease)
• It is a proliferative fibroplasia of the
subcutaneous palmar tissue, occurring in the
form of nodules and cords, that may result in
secondary progressive and irreversible flexion
contractures of the finger joints.
3. • Other changes include:
–thinning of the overlying subcutaneous fat
–adhesion to skin
–and later pitting or dimpling of the skin.
4. History
• Felix plater (1536-1614) gave the Ist description
of palmar fibromatosis.
• Henry Cline (1750-1836) described the anatomy
& recommended surgical release.
• Astley cooper (1768-1841) explained the etiology
as repeated trauma and described percutaneous
fasciotomy.
• Guillaume Dupuytrene (1834) gave detailed
anatomic pathology, C/F, natural history, surgical
technique, postop care, response, follow up.
5. Epidemiology
• Age: Incidence increases with increasing age and
peaks between 40-60 years
• Sex: Males > Females (7-15 times)
• Race: White Caucasians
• Geography: North European descent
• Genetics is Unclear (Autosomal dominant with
variable penetrance)
6. Viking’s Disease
• Greatest concentration in Scandinavia and Great
Britain (Ireland and Scotland)
• Viking heritage in original gene pool and follows
pattern of Viking travel (prevalence decreases as
distance increases from Europe)
• High prevalence in Australia due to British
population.
7. Curse of The MacCrimmons
• First known to be prevalent in
western isles of Scotland.
• MacCrimmons were
musicians and pipers to the
chieftains of the clan
MacLeod of Skye
• Contractures inhibited
playing bagpipes.
8. • Famous patients include Ronald Reagan,
Margaret Thatcher, and creator of Captain Hook
(inspiration for his claw hand).
10. Dupuytren’s Diathesis
• Strong gene expression causing physical findings.
• Present earlier in life (20s and 30s).
• Aggressive cord development with high incidence
of multi-digit and bilateral hand involvement.
• Knuckles (Garrod’s nodes), plantar fibromatosis
(Lederhose’s disease), penile fascial involvement
(Peyronie’s disease).
• High risk for poor surgical outcome due to higher
recurrence rates, greater risk of surgical technical
complications, and longer post-op care.
11. Patient Complaints
Fingers get in the way with:
Washing face
Combing hair
Putting hand in pocket
Racquet sports
Golf
Putting hand in glove
12. Symptoms
• First notice tender nodule or progressive
palmar cord development.
• May be painless, and may avoid care until
joint motion reduced.
• Symptoms may be present bilaterally, with
one hand occurring first (not necessarily
dominant hand).
13. • MCP joint affected first and then
PIP joint.
• Ring and small finger affected first,
after palmar involvement.
14. Palpable
Nodules and
Cords
• Firm nodules may be tender to palpation.
• Cords proximal to nodules painless.
• Atrophic grooves or pits in skin signify adherence to
the underlying fascia.
• Tender knuckle pads over dorsal aspect of PIP
joints--indicates aggressive disease.
15. Positive Table top Test:
The distance marked should be zero in
a normal hand with a negative table
top test.
16. Dynamic flexion contracture:
When MCP joint is at neutral, the PIP joint contracture
is more.
When MCP joint is flexed, the deformity at PIP is
reduced.
This is attributed to the Central Cord involvement.
20. The Palmar Aponeurosis
• Thick triangular fascial
layer that covers the
lumbrical and flexor
tunnels between the
thenar and hypothenar
eminences
• Proximally: palmaris
longus
• Distally: Longitudinal
bands, called
Pretendinous Bands
• Bifurcates distally to
pass on either side of
the tendons
21. Vertical Fibers
• Superficially they connect the aponeurosis to
the dermis
• Deep fibers are of three types:
1. Septa of Legueu and Juvara
2. McGrouther’s Fibers
3. Vertical septa between the lumbricals and flexor
tendons
22. • Septa of Legueu and Juvara are well developed fibrous
structures arising from the deep surface of the
aponeurosis at the level of the Metacarpal head and neck
• Pass down to the palmar plate and fascia over the
interossei
• Eight septa, one on either side - four fibro osseous tunnels
• Each tunnel has three compartments containing the
common neurovascular bundles and the lumbricals
23. Transverse Fibers
• Natatory Ligament (NL, Superficial transverse
metacarpal ligament, STML)
• Transverse ligament of the palmar aponeurosis
(TLPA): It is a distinct part of the palmar
aponeurosis and gives origin to the vertical fibers
of Legueu and Juvara
25. Pretendinous Bands
Three different insertions for the
pretendinous bands:
• Superficial layer: terminates into
the dermis distal to the MCP joint
• Intermediate layer: passes deep to
the natatory ligament and the
neurovascular bundles, merges
with the lateral digital sheath,
Spiral bands and may attach to the
retrovascular band
• Deep layer: passes vertically down
at the level of the A1 pulley and
terminates in the vicinity of the
extensor tendon
26. Hypothenar Aponeurosis
• Covers the muscles of the hypothenar
eminence
• Continuous with the ulnar border of
the palmar aponeurosis
• Merges distally with the tendon of
Abductor Digiti Minimi and continues
close to the lateral digital sheath
27. Thenar Aponeurosis
• Radial continuation of the palmar
aponeurosis, much thinner
• Skin over thenar aponeurosis more
mobile because there are a few
vertical fibers connecting it to the
dermis
28. Digital Fascia
• It holds the skin in
position as the fingers
or thumb move
1. Grayson’s ligament:
Midaxial, Palmar
2. Cleland’s ligament: Thicker,
Midaxial, Dorsal
29. 3. Lateral Digital Sheet: Superficial fascia
lateral to the Neurovascular bundles
4. Retrovascular band: Deep to the
Neurovascular bundles, longitudinal fibers
30. Spiral Band of Gosset:
Pretendinous band, the
lateral digital sheet and
the Grayson’s ligament
may involve the
retrovascular band
• Gradual contraction of the spiral cord pulls the
neurovascular bundle towards the midline which
may come to lie transverse to the long axis
32. Pathologic Anatomy
• Normal fascial structures in the hand and
digits are referred to as BANDS
• Diseased fascial structures in Dupuytren’s
are referred to as CORDS
• In Palm:
Pretendinous cords are involved resulting in
MCP Joint flexion. Does not affect the
neurovascular bundles and are painless.
Involvement of Vertical cords can cause pain
and triggering.
33.
34. Basic Pathology
• Myofibroblasts are the histologic
hallmark of Dupuytren’s contracture
• Increase in:
–Type III collagen
–Total collagen
–Lysyl oxidase
–Glycosoaminoglycans
• Increase in cellularity (fibroblasts).
35. Pathogenesis
• Local ischemia at the microvascular
level increase in fibroblast &
related cell types
• Fibroblasts then organize themselves
along line of stress cords
deformity
38. Role Of Protein Factors
• PDGF, FGF, TGF-B increased
collagen production
• Myofibroblasts are more sensitive
Nodules & Cords:
Major forms of diseased tissues
Two distinct histological tissues
39. Nodules
• Dense cellular collections of myofibroblasts: indicates
centers of high metaplastic activity.
• LUCK described 3 stages of progression of nodule:
1. Proliferative: Young nodules with non-stress
aligned fibroblasts, grows & fuses to skin
2. Involutional: Growth stops, Stress alignment of
fibroblasts, More collagen Fascial hypertrophy
Nodule cord units
3. Residual: Size reduces, Acelullar fibrous cords
41. Cords
• No myofibroblasts
• Highly organised collagen structure similar
to tendon
• Nodules produce the contraction by
pulling the cords which expand across the
joints
Myofibroblasts found in dermal &
epidermal tissue cause recurrence
43. Non Operative Management
• Collagenase Studies show good results in 90%
patients with a single injection and
maintained 9 months after treatment
• Radiotherapy, Dimethyl sulfoxide, Ultrasound,
Steroids, Colchicine, Alfa interferon: None has
shown any significant benefit
44. Operative Management
• Indications:
–A Positive Table Top Test: correlates with
MCP contracture of > 30-40°
–MCP joint contracture ≥ 40°
–Treatment of other digits on the same hand
should be considered when their MCP
contracture are 20-30° or more.
–PIP joint release if PIP joint contracture > 30°
45. • Important to distinguish true PIP joint
contracture from apparent contracture (due to
spiral cord)
• MCP joint contracture is measured with PIP
joint held in extension
• PIP joint contracture is measured with MCP
joint in flexion
46. Management Of Palmar Fascia
• Treatment options include:
–Radical vs. Selective vs. Segmental
Fasciectomy
–Fasciotomy
–Amputation
–Joint resection and arthrodesis
47. Surgical Fasciectomy
• Radical Fasciectomy: Mostly abandoned
– All palmar fascia removed
– High amounts of wound complications, and
recurrence
• Selective Fasciectomy: Most commonly used
– Removal of all diseased fascia in palm/finger
– Indicated when only ulnar one or two fingers
involved
– Rate of recurrence is 50%
– Need for another surgery: 15%
– Recurrence due to undetectable diseased fascia
remaining
48. • Segmental Fasciectomy
–Removal of one or more segments of
diseased fascia through multiple small
incisions in palms and fingers or
through transverse/longitudinal
plasties, with skin grafts
50. • Thin potentially avascular flap should be
avoided.
• Dissection start in normal anatomy and
proceed distally.
• Start cord release in palm and identify Neuro
Vascular Bundle>> then palmar-digital skin
>>then digital.
51. Skin Management
• Digital Skin Shortening can be
corrected by:
–Release of skin corrugations by division
of the vertical fibers running up to the
dermis
–Multiple Z plasties
–Open palm technique
–Skin grafting
52. Skin Replacement
• Skin shortage due to dermal contracture
• Prophylactic firebreak to separate the ends of
contracted fascia
• Recurrent disease
• Electively excised as Hueston’s
dermofasciectomy
• Skin graft
• Flap
53. Management of Volar Skin
• Three types:
–Direct closure
–Full-thickness skin grafting
–Open technique with wound
contraction
54. • Direct closure:
–Primary wound healing
–No need for skin grafts
–Simple post-op management
–Increased incidence of Hematoma and
Skin flap necrosis
55.
56. • Full thickness skin grafting:
Pros:
• Less recurrence where full thickness graft used,
modulating effect on underlying fascia
Cons:
• Recurrence still possible beyond areas of graft
• Graft loss
• Hematoma formation
• Immobilization may cause stiffness
• Altered sensation on graft
57.
58. • Open wound technique:
– Transverse incision in palm at level of midpalmar
crease and extensions in fingers
– Transverese incision is left open and covered with
non-adherent dressing
– Daily dry dressing changes, healing in weeks
– No granulation or epithelialization, instead
transverse wound contracts to pre-contracture
length
– Less hematoma, wound edge necrosis, and infection
– Inconvenience during 3-5 weeks for closure
59. Fasciotomy
• Diseased tissue incised but not removed
• Used mainly in elderly patients or severe
disease when unable to comply with
post-operative rehabilitation protocol
60. Joint Resection- Arthrodesis
• Severely contracted PIP joint
• Avoids the potential for recurrent
PIP joint contracture and potential
amputation neuroma
61. Amputation
• Rare
• May be indicated:
–In Flexion contracture of PIP joint, especially
little finger, when cannot be corrected
enough to make finger useful
–Or in case of vascular compromise
63. Collagenase
• Enzymatic percutaneous fasciotomy of
residual stage disease
• Collagenase diluted in calcium chloride
• Currently treatment only available at
stony brook medical center, under FDA
“orphan drug status” in phase III trials
• Injected straight into nodule
64. • Minimal side effects: tenderness at
injection site, hematoma, edema.
• Preliminary results by Badalamente and
Hurst show results of more than 90%
correction of MCP joint, 66% correction
of the PIP joint, and minimal recurrence
rates.
• Although collagenase is showing promise
in clinical trials, surgery is still considered
the standard of care
65. Needle Aponeurotomy
• Fascia contractures sectioned
percutaneously with sharp-edged bevel
of local anesthetic needle.
• The treatment is only performed in
Europe, primarily France.
• Outpatient, $150 for 20 minute session
and requires no physical therapy.
• Temporary treatment, not cure.
66. Gamma Interferon
• Gamma-interferon is a cytokine
produced by t-helper lymphocytes.
• Shown to decrease fibroblast replication,
alpha-smooth-muscle actin expression,
and collagen production.
• Fails to have long term disease free effect
67. Postoperative Rehabilitation
• Commenced after early inflammatory phase (3-
5 days)
• ROM exercises for short periods, repetitive
• Splinting:
– Initially static for 2 weeks with MCP in 10-20°
Flexion, PIP straight and DIP joint free
– After 2 weeks PIP splint at night for 8-10 weeks
• Scar management
68. Complications
• Intra-operative:
– Digital nerve division.
– Hematoma formation.
– Wound healing difficulties (flaps).
– Vascular compromise of a digit.
• Post-operative:
– Patient compliance.
– Reflex sympathetic dystrophy (flare reaction).
(1-8% prevalence, 2x more common in women)
• Recurrence up to 63%.
69. In Case Of Intra Operative Arterial
Insufficiency
Due to-direct trauma, traction and vasospasm
Flex the finger
Warm the finger with warm irrigant solution
Apply topical papavarine (30 mg/mL) / lignocaine
Be patient. Allow the relaxation, warming, and
antivasospasm interventions time to work. The artery may
require up to 10 minutes for the restoration of perfusion
If arterial insufficiency persists beyond 10 minutes, explore
the digital artery throughout the extent of dissection.
Repair of a partial or complete laceration should be
performed under the operating microscope. A vein graft
may be necessary if undue tension is present
70. Recurrence
• Presence of diseased tissue in surgically treated
field.
• Cure at genome level: Surgical excision improves
hand function.
• Recurrence more common at young ages and in
Dupuytren’s diathesis.
• Most commonly diseased tissue from untreated
areas extends into treated areas.
71. • Recurrence rates are more in presence of
residual tissue incompletely excised,
leaving behind myofibroblasts in skin.
• Full skin grafts rarely recur, due to
complete removal of all nodular area in
dermis and epidermis.
72. Summary
• Dupuytren’s contracture is a genetic disease.
• Patients must understand that surgery is not a
cure, and has potential side effects.
• Future treatment more medical and less
surgical, with eventual cure to be at genomic
level.