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Aloe vera
- 2. •Member of the lily family. •240 species of Aloe . •Succulent, perennial, evergreen. •Native to Africa, but is now widespread. •It is a bitter herb with a wide range of medicinal properties. •It contains over 75 compounds,
- 3. Known as the “lily of the desert”. Considered the “plant of immortality” by many native peoples. Very long history of medical usage… 2200 B.C.- Mentioned on Sumerian clay tablets. 1550 B.C.- The Ebers Papyrus states 12 recipes for mixing Aloe with other agents to treat human disorders. Usually the whole leaf was ground and mixed with another medicinal agent
- 4. First modern medical paper published in 1934. Described how the whole leaf was used to treat radiation dermatitis. Many papers published in the 20th century describing a wide range of medicinal properties. Reports have mainly focused on the antidiabetic, anticancer, and antimicrobial properties of the whole leaf, gel, or juice of the plant. Many species of Aloe have been studied.
- 5. Vitamins Mono and poly saccharides, glucomannans Anthraquinones Most important: Aloin, and Emodin Cholesterol, Campesterol, Sisosterol, and Lupeol Salicyclic acid 3% of Aloe Vera gel Fatty Acids Inert except when in topical treatments Saponins Ca, Na, K, Mg, Mn, Cu, Zn, Cr, and Se Sugars Lignins Lipases, proteases, kinases Minerals Vitamin D, A, C, E and B12 Enzymes Aspirin-like Amino Acids 20 amino acids
- 6. Added because of known rejuvenating action Mode of Action: Polysaccachrides act as moisturizers Stimulates the fibroblasts to replicate faster Smoothes skin because sticks epidermal cells together which normally flake Interferes with melanin deposit production which lead to “liver spots”
- 7. Decrease in blood glucose due to stimulation of insulin secretion Decrease in cholesterol, triglycerides, phospholipids, and free fatty acids from increased clearance and decreased transporters
- 8. 50% gel leaf solution, complete inhibition of Staphylococcus aureus Due to phenolics Efficacy of gel or leaf? S. aureus inhibited by both Other bacteria inhibited by just leaf or gel
- 9. Shows increased healing effects on 2nd degree burns Anti-inflammation and wound healing promotion Vessels return to normal size quicker than with untreated burns
- 10. When aloe is combined with other antimicrobials, a wound heals faster than with the antimicrobial alone. Possibly due to its moisturizing capability as well.
- 11. Asian practice of ingesting herbs to support the immune system May have a direct inhibitory effect on microbes Also, selectively modulates cells of the immune system
- 12. Gel and latex. Gel- leaf pulp or mucilage obtained from the parenchymal tissue. Latex- bitter, yellow substance obtained from pericyclic tubules just beneath the outer skin of the leaves. (otherwise called ‘Aloe juice’) These terms are often confused by consumers. Using a freshly cut leaf is thought to be the most effective treatment.
- 13. Dental Health and Hygiene 2. Provides Rapid Soothing 3. Aids in Healthy Digestion 4. Immune Support and Function Regulates Weight and Energy Levels 6. Collagen and Elastin Repair 7. Daily Dose of Minerals 8. Daily Dose of Vitamins 9. Anti-inflammatory Properties 10. Essential Amino Acids 1. 5.
- 15. AMIT PRAKASH SAHOO ROLL NO. – 3 CLASS-X SCHOOL-KV AVIKANAGAR
Editor's Notes
- Vitamin A is antioxidant Vitamin B12 very rare in plants and so this is very important for vegetarians Enzymes: when taken orally help with digestion by breaking down sugars and fats, one in particular, Bradykinase, reduces inflammation when applied topically to skin Minerals: many needed for proper functioning of various enzyme systems in metabolic pathways Sugars: come from mucilage layer of plant, help enhance the immune system and help to detoxify, some form a barrier in gut to prevent absorption of unwanted materials, gluco-mannans: not broken down in gut and appear in blood stream in same form where they are able to help regulate immune system, topically the sugars are main moisturisers Anthraquinones: there are 12 of these phenolics, found in the sap, aid in absorption in GI tract, have anti-microbial, anti-viral and pain killing activity Lignins: gives aloe a penetrating effect when topical so can be absorbed through skin Saponins: capable of cleansing and have antiseptic properties, also antimicrobial activity Fatty Acids: involved in anti-inflammatory Amino acids: 20 out of 22 amino acids including 7 of the 8 essential amino acids the body cannot synthesize
- Fibroblasts are what produce collagen and elastin fibers so skin becomes more elastic and less wrinkled Also can help remove already establish liver spots\\
- The comparative antimicrobial activities of the gel and leaf of Aloe vera were tested against Staphylococcus aureus, Pseudomonas aeruginosa, Trichophyton mentagraphytes, T. schoeleinii, Microsporium canis and Candida albicans. Ethanol was used for the extraction of the leaf after obtaining the gel from it. Antimicrobial effect was measured by the appearance of zones of inhibition. Antimicrobial susceptibility test showed that both the gel and the leaf inhibited the growth of S. aureus ( 18.0 and 4.0 mm, respectively). Only the gel inhibited the growth of T. mentagrophytes ( 20.0 mm), while the leaf possesses inhibitory effects on both P. aeruginosa and C. albicans. The results of this study tend to give credence to the popular use of both Aloe vera gel and leaf.
- * Throughout test, the vessels were more dilated and had increased postcapillary venular permeability
- Full-thickness excised wounds were created on the dorsum of Sprague-Dawley rats under anaesthesia. The wounds were treated with topical agents three times daily for fourteen days, then observed until healed. Used, saline contol, placebo (aqueous cream) control, silver sulphadiazine (SSD) cream 1%, SSD 0.5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound healing was delayed by saline and SSD. Nystatin and Aloe vera, when added to SSD, reversed that effect. These data suggest that a dry wound (saline) heals slowly. Infection control without delay of wound healing is most appealing and clinical trials are planned.
- The current practice of ingesting phytochemicals to support the immune system or to fight infections is based on centuries-old tradition. While it may have a direct inhibitory effect on microbial organisms, It also selectively modulates cells of the immune system. They will study the influence on immune cells as well as microbes to provide useful insights to the development of potentially useful new pharmacological agents.