2. Introduction
Diarrheal diseases rank among the “top
three” causes of death in pediatric
Population of the developing world
Globally, approximately 4-5 million deaths
occur as a result of diarrheal diseases every
year
Eight out of these 10 deaths are in the first 2
years of life.
Diarrheas account for about 20% of the
hospitalized pediatric cases in India.
3. Definition
Diarrhea means passage of 3 or more
loose or watery motions per 24 hours, resulting
in excessive loss of fluid and electrolytes in
stools.
4. Epidemiology
Worldwide, there are an estimated 1.7 billion
episodes of diarrhea each year
The incidence and morbidity of diarrhea are
more prominent in low-income countries
Among children younger than 5 years old
5. Diarrheal disturbances involve the stomach
and intestines (gastroenteritis),
The small intestine (enteritis),
The colon (colitis), or
The colon and intestines (enterocolitis).
7. Types
Secretory diarrhea has a tendency to be
watery, voluminous and persistent even when
no feeding is given orally.
It is usually caused by an external or internal
secretagogue (cholera toxin, lactase
deficiency)
Secretagogue : a substance which promotes secretion.
8. Osmotic diarrhea
Ingestion of a poorly absorbed solute because
of an inherent character of the solute
(magnesium phosphate, alcohol, sorbitol) or a
small bowel defect (lactose in lactase
deficiency in brush border)
It tends to be watery and acidic with reducing
substances.
9. Motility diarrhea is associated with increased
(irritable bowel syndrome) or delayed motility
(intestinal pseudo-obstruction)
Acute diarrhea refers to diarrhea that begins
acutely and terminates within a week or so,
only a small proportion of cases passing to the
second week or even beyond
10. Chronic diarrhea refers to diarrhea beyond 2
weeks. The term is best reserved for cases
with an obvious malabsorption or an
underlying organic disease without obvious
malabsorption.
Persistent diarrhea denotes an episode of
acute diarrhea, presumably of infective origin,
that lasts for 2 weeks or more
11. Intractable diarrhea of infacy, should be
reserved for cases who have onset of
protracted diarrhea before the age of 3
months.
These infants start as an infective diarrhea,
become dehydrated and wasted and have
high mortality. They need emergency
treatment.
13. Etiology…who is in risk ?
Sanitary and personal hygiene standards of
the community.
Infants and children are more frequently and
more severely affected
The specific etiology is not always
identified
15. Pathogenesis
Adhesion to the intestinal mucosal wall
e.g. Enteropathogenic E. coli (EPEC) which are further
categorized as class I EPEC (showing localized adherence)
and class II EPEC (showing diffuse adherence).
Elaboration of an exotoxin , (secretory diarrhea)
e.g. rotavirus, enterotoxigenic E. coli (ETEC), Vibrio
cholera, Aeromonas hydrophilia, Plesiomonas shigelloides,
causes excessive secretions.
fasting has no effect
Mucosal invasion (exudative diarrhea),
e.g. enteroinvasivem E. coli (EIEC), Shigella, Salmonella
(nontyphi), Cl. Defficile, Campylobacter jejuni, Yersinia
enterocolitica, enteropathogenic E. coli (EPEC), rotavirus,
damage and exudative blood. No effect of fasting.
16. Pathophysiology
Invasion of the GI tract by pathogens
results in increased intestinal secretion as
a result of enterotoxins, cytotoxic mediators, or
decreased intestinal absorption secondary to
intestinal damage or inflammation
Enteric pathogens attach to the mucosal
cells and form a cuplike pedestal on which
the bacteria rest
17. The pathogenesis of the diarrhea depends on
whether the organism remains attached to the
cell surface, resulting in a secretory toxin
(noninvasive, toxin-producing, non
inflammatory type diarrhea), or penetrates the
mucosa (systemic diarrhea).
Non-inflammatory diarrhea is the most
common diarrheal illness, resulting from the
action of enterotoxin that is released after
attachment to the mucosa.
18. The most serious and immediate physiologic
disturbances associated with severe diarrheal
disease are dehydration, acid-base
imbalance with acidosis, and shock that
occurs when dehydration progresses to the
point that circulatory status is seriously
imp.aired
19. Clinical features
Mild
In mild cases, onset is usually insidious with 2
to 5 motions which may be,
Loose, green, offensive and contain mucus and
milk curds.
The volume may be small or large.
The attack usually subside in a day or two without
any remarkable constitutional manifestations or
dehydrations
20. Moderate
The number of motions is 10 or more and
constitutional symptoms like
Fever,
Irritability
Anorexia and vomiting.
Mild dehydration (3 to 5%)
21. Severe
Child passes “too many”
loose motions
Severe vomiting to the
extent that nothing is
retained and
The oral intake becomes
virtually impracticable
Sudden rather than
gradual onset
Moderate (5 to 10%) to
severe (>10%)
dehydration.
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26. Diagnosis
History
Careful history that seeks to discover the
possible cause of diarrhea,
To assess the severity of symptoms
The risk of complications, and
To elicit information about current symptoms
indicating other treatable illnesses
27. The history should include
questions about
Recent travel,
Exposure to untreated
drinking or washing water
sources,
Contact with animals or birds,
Daycare center attendance,
Recent treatment with
antibiotics, or recent diet
changes.
28. History questions should
also explore the presence
of other symptoms, such
as
Fever and vomiting,
Frequency and character of
stools (e.G., Watery,
bloody),
Urinary output,
Dietary habits, and
Recent food intake
32. Diagnosis
Lab diagnosis
The stool can be examined for the presence of
ova, parasites, infectious organisms, viruses, fat,
and undigested sugars.
Laboratory evaluation of serum and urine helps
identify electrolyte imbalances and other
deficiencies.
33. Diagnosis
Watery, explosive stools suggest glucose
intolerance
Foul-smelling, greasy, bulky stools suggest fat
malabsorption
Develops after the introduction of cow's milk,
fruits, or cereal may be related to enzyme
deficiency or protein intolerance
Neutrophils or red blood cells in the stool
indicate bacterial gastroenteritis or IBD.
The presence of eosinophils suggests protein
intolerance or parasitic infection
34. Stool cultures
Gross blood or occult blood
Gross blood or occult blood may indicate
pathogens, such as Shigella, Campylobacter, or
hemorrhagic Escherichia coli strains.
Enzyme-linked immunosorbent assay (ELISA)
used to confirm the presence of rotavirus or
Giardia organisms
Complete blood count (CBC), Serum
electrolytes, Creatinine, and BUN
35. If there is a history of recent antibiotic use, test the
stool for C. difficile toxin
When bacterial and viral culture results are
negative and when diarrhea persists for more than
a few days, examine stools for ova and parasites
A stool specimen with a pH of less than 6 and the
presence of reducing substances may indicate
carbohydrate malabsorption or secondary lactase
deficiency
Stool electrolyte measurements may help identify
children with secretory diarrhea
36. Management
Medical management
Goal
To correct the fluid and electrolyte imbalances
Mild and moderate dehydration
Oral rehydration therapy (Home & Hospital)
Severe
Intravenous infusion with a solution chosen to
correct the specific electrolyte imbalances
37. Medical management……….
Introduce clear liquids or breast milk
Encourage the child to progress to a regular diet.
Foods generally are not withheld for more than 1
to 2 days.
Bacteria or parasites: antimicrobial therapy
Antiemetics and antidiarrheals (Antimotility drugs
such as loperamide are not recommended in
children, the use of antiemetic agents have
historically not been recommended)
38.
39.
40. Ongoingstool losses should be replaced on a
1 : 1 basis with ORS
Probiotics when used in conjunction with ORS
reduces the duration of antibiotic-associated
diarrhea in children by 1 day
Severe dehydration and shock, IV fluids are
initiated
47. Assessment
History
Physical examination
Assess onset, frequency, color, amount, and
consistency of stools.
Monitor the amount and type of vomitus
Observing for signs and symptoms of dehydration
Evaluate urinary output and specific gravity
Accurate weight must be obtained on admission and
daily thereafter
Monitor vital signs every 2 to 4 hours (fever causes
waterloss)
Assess skin integrity, especially in the perineal and
rectal areas, and note any breakdown or rashes
48. Nursing diagnosis
Diarrhea related to infectious process
Fluid electrolyte imbalance
Risk for Impaired skin integrity
Imbalanced nutritional status
Parental anxiety
Fatigue/Discomfort
Knowledge deficit
Acute pain ( abdominal cramps)
49. Planning and implementation
Diarrhea related to infectious process
Obtain baseline vital signs and monitor ever 2–4
hr
Observe stools for amount, color, consistency,
odor, and frequency
Test stools for occult blood
Monitor results of stool culture and sample for ova
and parasites
Wash hands well before and after contact with the
child
50. Planning and implementation
Diarrhea related to infectious process
Isolate the child until the cause of the diarrhea is
determined
Assist the child with toileting and hygiene.
Administer prescribed oral rehydration and
intravenous solutions.
Notify the healthcare provider if diarrhea persists,
stool characteristics change, or other symptoms
of dehydration electrolyte imbalance occur.
51. Planning and implementation
Fluid electrolyte imbalance
Monitor intake and output. Document time of each
voiding. Weigh all diapers.
Compare admission weight to preadmission weight.
Assess weight daily.
Assess level of consciousness, skin turgor, mucous
membranes, skin color and temperature, capillary refill,
eyes, and fontanelles every 4 hours.
Assess for vomiting.
Provide oral fluid and electrolyte replacement solution
if able to tolerate.
Provide and maintain IV replacement therapy, as
ordered
52. Planning and implementation
Risk for Impaired skin integrity
Assess skin of perineum and rectum for signs of
skin breakdown or irritation.
Provide prevention or restorative care for infants
as follows:
Preventive Care:
Change diapers every 2 hr or as needed.
Wash diaper area after each soiling.
Apply A&D ointment, Aquaphor, or another barrier
ointment with each diaper change.
53. Planning and implementation
Risk for Impaired skin integrity
Restorative Care:
Leave the buttocks open to air for a few minutes
several times daily, placing absorbent pads under
the infant.
Notify the healthcare provider if the skin is
severely broken or peeling or if a rash is present.
For toddlers and older children: Tub bathe at least
daily (if condition allows) in tepid water.
Pat the area dry.
Discourage the wearing of underwear if possible.
Apply barrier ointment
54. Planning and implementation
Imbalanced nutritional status
Oral and IV rehydration
Dietary history
Diet plan
Infants are breastfed or given formula feed.
Small amounts of normal diet for age are
provided
55. Planning and implementation
Parental / child anxiety
Allow them to talk and ask questions
encourage parents to room-in
Reassurance
Place the child’s favorite toys and comfort objects
Using therapeutic play techniques, such as
allowing the child to manipulate equipment, can
reduce anxiety
56. Planning and implementation
Fatigue / Discomfort
Provide a quiet, restful environment
Cluster nursing care to allow for periods of
uninterrupted rest
Keep the child’s mouth moistened with a wet
washcloth, or an occasional ice chip
Provide skin care after each diarrheal episode to
maintain skin integrity.
Avoid using commercial baby wipes that contain
alcohol as these irritate the skin and cause
discomfort for the child.
57. Planning and implementation
Knowledge deficit
Reassurance
Involve parents in care
Educate,
To monitor for signs of dehydration
The amount of fluids taken by mouth
To assess the frequency and amount of stool losses
Careful monitor intake and output
ORT at home
Introduction of a normal diet
Hygiene
58. Prevention
Personal hygiene,
Protection of the water supply from
contamination,
Careful food preparation.
Disposal of soiled diapers,
Proper hand washing,
Isolation of infected persons
Meticulous attention to perineal hygiene,