1. PUBLICATIONS
1. J. Content, B. Lebleu, A. Zilberstein, H. Berissi and M. Revel (1974). Mechanism of the Interferon-Induced
Block of mRNA Translation in Mouse L-Cells: Reversal of the Block by Transfer RNA. FEBS Letts. 41, 125-130.
2. J. Content, B. Lebleu, U. Nudel, A. Zilberstein, H. Berissi and M. Revel (1975). Blocks in Elongation and
Initiation of Protein Synthesis Induced by Interferon Treatment in Mouse L-cells. Eur. J. Biochem. 54, 1-10.
3. A. Zilberstein, J. Content, B. Lebleu, H. Berissi, L.M. Shulman and M. Revel (1975). Mechanism of Interferon-
Induced Blocks of mRNA Translation in Mouse L-cells and its Reversal by tRNA. Isr. J. Med. Sci. 11, 1211.
4. A. Zilberstein, B. Dudlock, H. Berissi and M. Revel (1976). Control of mRNA Translation by Minor Species of
Leucyl-tRNA in Extracts from Interferon-Treated L-cells. J. Mol. Biol. 108, 43-54
5. A. Zilberstein, P. Federman, L. Shulman and M. Revel (1976). Specific Phosphorylation in vitro of a Protein
Associated with Ribosomes of Interferon-Treated Mouse L-cells. FEBS Letts. 68, 119-124.
6. A. Zilberstein, L. Shulman, B. Dudock and M. Revel (1976). Specific Control of mRNA Translation by Minor
Species of tRNA in Extracts from Interferon-Treated L-cells. Isr. J. Med. Sci. 12, 1384.
7. A. Zilberstein, A. Schmidt, A. Kimchi, L. Shulman and M. Revel (1977). Regulation of the Interferon-Induced
Protein Phosphorylation and Translational Inhibition. Isr. J. Med. Sci. 13, 941.
8. A. Kimchi, A. Zilberstein, A. Schmidt, L. Shulman, P. Federman and M. Revel (1978). Interferon-Induced
Translational Inhibitors: I. The Protein Kinase System. Isr. J. Med. Sci. 14, 183.
9. A. Zilberstein, A. Schmidt, H. Berissi, P. Federman and M. Revel (1978). Interferon-Induced Translational
Inhibitors: II. The Oligo-isoadenylate Synthetase. Isr. J. Med. Sci. 14, 184.
10. A. Zilberstein, A. Kimchi, A. Schmidt and M. Revel (1978). Isolation of two Interferon-Induced Translational
Inhibitors: A Protein Kinase and an Oligo-isoadenylate Synthetase. Proc. Natl. Acad. Sci. USA 75, 4734-4738.
11. A. Schmidt, A. Zilberstein, L. Shulman, H. Berissi, P. Federman and M. Revel (1978). Interferon Action:
Isolation of Nuclease F, a Translational Inhibitor Activated by Interferon-Induced (2’-5’) oligoisoadenylate. FEBS
Letts. 95, 257-264.
12. Y. Chernajovsky, A. Kimchi, A. Schmidt, A. Zilberstein and M. Revel (1979). Differential Effects of Two
Interferon-Induced Translational Inhibitors on Initiation of Protein Synthesis. Eur. J. Biochem. 96, 35-41.
13. A. Kimchi, A. Zilberstein, A. Schmidt, L. Shulman and M. Revel (1979). The Interferon-Induced Protein Kinase
PK-i from Mouse-L Cells. J. Biol. Chem. 254, 9846-9853.
14. R. Kaempfer, R. Israeli, H. Rosen, S. Knoller, A. Zilberstein, A. Schmidt and M. Revel (1979). Reversal of the
Interferon-Induced Block of Protein Synthesis by Purified Preparations of Eucaryotic Initiation Factor 2. Virology
99, 170-173.
15. H.F. Lodish, A. Zilberstein, G.J.A.M. Strous and M. Porter (1980). Processing and Maturation of the Vesicular
Stomatitis Virus Glycoprotein. Eur. J. Cell Biol. 22, 789-790.
16. A. Zilberstein, M.D., Snider, M. Porter and H.F. Lodish (1980). Mutants of Vesicular Stomatitis Virus Blocked at
Different States in Maturation of the Viral Glycoprotein. Cell 21, 417-427.
17. Y. Mory, J. Ben-Barak, D. Segev, B. Cohen, D. Novick, D.G. Fischer, M. Rubinstein, S. Kargman, A. Zilberstein,
M. Vigneron and M. Revel (1986). Efficient Constitutive Production of Human IFN-γ in Chinese Hamster Ovary
Cells. DNA 5, 181-193.
18. P.B. Sehgal, A. Zilberstein, R. Ruggieri, L.T. May, A. Ferguson-Smith, D.L. Slate, M. Revel and F.H. Ruddle
(1986). Human Chromasome 7 Carries the Beta2 Interferon Gene. Proc. Natl. Acad. Sci. USA 83, 5219-5222.
19. A. Zilberstein, R. Ruggieri, J.H. Korn and M. Revel (1986). Structure and Expression of cDNA and Genes for
Human Interferon-Beta2. A Distinct Species Inducible by Growth-Stimulatory Cytokines. EMBO J. 5, 2529-2537.
20. M. Revel, A. Zilberstein, R. Ruggieri, M. Rubinstein and L. Chen (1987). Autocrine Interferons and Interferon
β-2. J. Interferon Res. 7, 529-536.
21. J.H. Korn, Y. Mory, A. Zilberstein, H. Holtmann, M. Revel and D. Wallach (1988). Cloning of Genomic DNA for
Tumor Necrosis Factor and Efficient Expression in CHO cells. Lymphokine Res. 7, 349-358.
22. L. Chen, Y. Mory, A. Zilberstein and M. Revel (1988). Growth Inhibition of Human Breast Carcinoma and
Leukemia/Lymphoma Cell Lines by Recombinant IFN-β2. Proc. Natl. Acad. Sci. USA 85, 8037-8041.
23. J. Sanceau, R. Falcoff, A. Zilberstein, F. Beranger, J. Lebeau, M. Revel and C. Vaquero (1988). Interferon-β2
(BSF-2) mRNA is Expressed in Human Monocytes. J. Interferon Res. 8, 473-481.
24. B. Margolis, S.-G. Rhee, S. Felder, M. Mervic, R.M. Lyall, A. Levitzki, Ullrich, A. Zilberstein and J. Schlessinger
(1989). EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF-
Receptor Signalling. Cell 57, 1101-1107.

2. PAGE 2 OF 6 ASHER ZILBERSTEIN, PHD
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25. R.M. Lyall, A. Zilberstein, A. Gazit, C. Gilon, A. Levitzki and J. Schlessinger (1989). Tyrphostins Inhibit EGF-
Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation. J. Biol. Chem. 264,
14503-14509.
26. J.R. Downing, B.L. Margolis, A. Zilberstein, R.A. Ashmun, A. Ullrich, C.J. Sherr and J. Schlessinger (1989).
Phospholipase C-γ, A Substrate for PDGF Receptor Kinase, is not Phosphorylated on Tyrosine During the
Mitogenic Response to CSF-1. EMBO J. 8, 3345-3350.
27. R. Hazan, B. Margolis, M. Dombalagian, A. Ullrich, A. Zilberstein, and J. Schlessinger (1990). Identification of
Autophosphorylation Sites of HER2/neu. Cell Growth and Differentiation 1, 3-7.
28. B. Margolis, F. Bellot, A.M. Honegger, A. Ullrich, J. Schlessinger, and Zilberstein (1990). Tyrosine Kinase
Activity is Essential for the Association of Phospholipase-C-γ with the Epidermal Growth Factor Receptor. Mol.
Cell. Biol. 10, 435-441.
29. B. Margolis, A. Zilberstein, C. Franks, A. Ullrich, S. Felder, S. Kremer, K. Skorecki, S.-G. Rhee and J.
Schlessinger (1990). Effect of Phospholipase C-γ Overexpression on PDGF-Induced Second Messengers and
Mitogenesis. Science 248, 607-610.
30. W.H. Burgess, C.A. Dionne, J. Kaplow, R. Mudd, R. Friesel, A. Zilberstein, J. Schlessinger and M. Jaye (1990).
Characterization and cDNA Cloning of Phospholipase C-γ, a Major Substrate for HBGF-1 (acidic FGF)-Activated
Tyrosine Kinase. Mol. Cell. Biol. 10, 4770-4777.
31. B. Margolis, N. Li, A. Koch, M. Mohammadi, D.R. Hurwitz, A. Zilberstein, Ullrich, T. Pawson and J. Schlessinger
(1990). The Tyrosine Phosphorylated Carboxyterminus of the EGF-Receptor is a Binding Site for GAP and
PLC-γ. EMBO J. 9, 4375-4380.
32. C.-Y.J. Hsu, D.R. Hurwitz, M. Mervic and A. Zilberstein (1991). Autophosphorylation of the Intracellular Domain
of the EGF-Receptor Results in Different Effects on its Tyrosine Kinase Activity with Various Peptide Substrates.
J. Biol. Chem. 266, 603-608.
33. H. App, R. Hazan, A. Zilberstein, A. Ullrich, J. Schlessinger and U. Rapp (1991). EGF Stimulates Association
and Kinase Activity of Raf-1 with the EGF Receptor. Mol. Cell Biol. 11, 913-919.
34. G.E. Bilder, J.A. Krawiec, K. McVety, A. Gazit, C. Gilon, R. Lyall, Zilberstein, A. Levitzki, M.H. Perrone and A.B.
Schreiber (1991). Tyrphostins Inhibit PDGF-Induced DNA Synthesis and Associated Early Events in Smooth
Muscle Cells. Amer. J. Physiol. 260, 721-730.
35. H.K. Kim, J.W. Kim, A. Zilberstein, B. Margolis, J.G. Kim, J. Schlessinger and S.G. Rhee (1991). PDGF
Stimulation of Inositol Phospholipid Hydrolysis Requires PLC-γ1 Phosphorylation on Tyrosine Residues 783 and
1254. Cell 65, 435-441.
36. T. Yoneda, R.M. Lyall, M.M. Alsina, P.E. Persons, A.P. Spada, A. Levitzki, Zilberstein and G.R. Mundy (1991).
The Antiproliferative Effects of Tyrosine Kinase Inhibitors on a Human Squamous Cell Carcinoma In Vitro and in
Nude Mice. Cancer Res. 51, 4430-4435.
37. S.M. Thomas, M. Hayes, G. D’Arcangelo, R.C. Armstrong, B.E. Meyer, Zilberstein, J.S. Brugge and S.
Halegoua (1991). Induction of Neurite Outgrowth by v-src Mimics Critical Aspects of Nerve Growth Factor-
Induced Differentiation. Mol. Cell Biol. 11, 4739-4750.
38. C.-Y.J. Hsu, P.E. Persons, A.P. Spada, R..A. Bednar, A. Levitzki and Zilberstein (1991). Kinetic Analysis of the
Inhibition of the EGF Receptor Tyrosine Kinase by Lavendustin-A and its Analogue. J. Biol. Chem. 266,
21105-21112.

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39. K.-T. Yu, R. Lyall, N. Jariwala, A. Zilberstein and J. Haimovich (1991). Antigen and Ionophore-Induced Signal
Transduction in Rat Basophilic Leukemia Cells Involves Protein Tyrosine Phosphorylation. J. Biol. Chem. 266,
22564-22568.
40. D.C. Renard, M.M. Bolton, S.G. Rhee, B.L. Margolis, A. Zilberstein, J. Schlessinger and A.P. Thomas (1992).
Modified Kinetics of Platelet-Derived Growth Factor-Induced Ca2+ Increased in NIH 3T3 Cells Overexpressing
Phospholipase C-γ1. Biochem. J. 281, 775-784.
41. C.-Y.J. Hsu, M.V. Jacoski, M.P. Maguire, A.P. Spada and A. Zilberstein. 1992. Inhibition Kinetics and
Selectivity of the Tyrosine Kinase Inhibitor Erbstatin and a Pyridone-Based Analogue. Biochem. Pharmacol. 43,
2471-2477.
42. K.B. Reddy, G.L. Mangold, A.K. Tandon, T. Yoneda, G.R. Mundy, A Zilberstein and C.K. Osborne. 1992.
Inhibition of Breast Cancer Cell Growth In Vitro by a Tyrosine Kinase Inhibitor. Cancer Res. 52, 3636-3641.
43. M.P. Maguire, K.R. Sheets, K. McVety, A.P. Spada and A. Zilberstein. 1994. A New Series of PDGF Receptor
Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives. J. Med. Chem. 37, 2129-2137.
44. K.-T. Yu, G. Nuss, R. Boyce, N. Jariwala, G. Owens, A. Pennetti, W. Chan, D.-C. Zhang, M.N. Chang and A.
Zilberstein. 1994. Inhibition of IL-1 Release from Human Monocytes and Suppression of Streptococcal Cell
Wall and Adjuvant-Induced Arthritis in Rats by an Extract of Tripterygium Wilfordii Hook. General Pharmacology
25, 1115-1122.
45. D.A. Vardy, C. Kari, G.S. Lazarus, P. Jensen, A. Zilberstein, G.D. Plowman and U. Rodeck. 1995. Induction of
an EGF Receptor Dependent Autocrine Loop in Human Keratinocytes by Insulin/IGF-1. J. Cell. Physiol. 163,
257-265.
46. W. Xian, K. Kiguchi, A. Imamoto, T. Rupp, A. Zilberstein and J. DiGiovanni. 1995. Activation of the Epidermal
Growth Factor Receptor by Skin Tumor Promoters and Skin Tumors from SENCAR Mice. Cell Growth and
Differentiation 6, 1447-1455.
47. M.R. Myers, N.N. Setzer, A.P. Spada, A.L. Zulli, J.-Y. Hsu, A. Zilberstein, S.E. Johnson, L.E. Hook and M.V.
Jacoski. 1997. The Preparation and SAR of 4-(Anilino), 4-(Phenoxy) and 4-(Thiophenoxy)-Quinazolines:
Inhibitors of p56lck and EGF-R Tyrosine Kinase Activity. Bioorganic and Med. Chem. Lett., 7, 417-420.
48. M.R. Myers, N.N. Setzer, A.P. Spada, P.E. Persons, C.Q. Ly, M.P. Maguire, A.L. Zulli, D.L. Cheney, A.
Zilberstein, S.E. Johnson, C.F. Franks and A.J. Mitchell. 1997. The Synthesis and SAR of New 4-(N-Alkyl-N-
Phenyl)Amino-6,7-Dimethoxyquinazolines and 4-(N-Alkyl-N-Phenyl)Amino-Pyrazolo[3,4-d]Pyrmidines, Inhibitors
of CSF-1R Tyrosine Kinase Activity. Bioorganic and Med. Chem. Lett., 7, 421-424.
49. J. Regan, D. McGarry, J. Bruno, D. Green, J. Newman, C.-Y. Hsu, J. Kline, J. Barton, J. Travis, Y.M. Choi, F.
Volz, H. Pauls, R. Harrison, A. Zilberstein, S.A. Ben-Sasson and M. Chang. 1997. Anionic- and Lipophilic-
Mediated Surface Binding Inhibitors of Human Leukocyte Elastase. J. Med. Chem. 40, 3408-3422.
50. F.-C. Huang, W.-K. Chan, K.J. Moriarty, D.-C. Zhang, M.N. Chang, W. He, K.-T. Yu and A. Zilberstein. 1998.
Novel Cytokine Release Inhibitors. Part I: Triterpenes. Bioorganic and Med. Chem. Lett., 8, 1883-1886.
51. W. He, F.-C. Huang, A. Gavai, W.-K. Chan, G. Amato, K.-T. Yu and Zilberstein. 1998. Novel Cytokine Release
Inhibitors. Part III: Truncated Analogs of Tripterine. Bioorganic and Med. Chem. Lett., 8, 3659-3664.
52. W. He, A. Gavai, F.-C. Huang, J. Regan, B. Hanney, G. Poli, J. Bruno, W.-K. Chan, S.W. Djuric, K.-T. Yu and A.
Zilberstein. 1999. Novel Cytokine Release Inhibitors. Part IV: Analogs of Podocarpic Acid. Bioorganic and
Med. Chem. Lett., 9, 469-474.
53. L. Hamel, M. Kenney, Z. Jayyosi, A. Ardati, K. Clark, A. Spada, A. Zilberstein, M. Perrone, J. Kaplow, L. Merkel
and C. Rojas. 2000. Induction of Heat Shock Protein 70 by Herbimycin A and Cyclopentenone Prostaglandins
in Smooth Muscle Cells. Cell Stress and Chaperons. 5, 121-131.
54. H. Zhu, S. McElwee-Witmer, M. Perrone, K. L. Clark and A. Zilberstein. 2000. Phenylephrine Protects
Neonatal Rat Cardiomyocytes from Hypoxia and Serum Deprivation-Induced Apoptosis. Cell Death and
Differentiation. 7, 773 – 784.
55. C. C. W. Arendt, G. Tang and A. Zilberstein. 2003. Vector Systems for the Delivery of small interfering RNAs:
Managing the RISC. ChemBioChem.,4, 1129 – 1136.
56. F. Long, H. Liu, C. Hahn, P. Sumazin, M.Q. Zhang and A. Zilberstein. 2004. Genome-Wide Prediction and
Analysis of Function-specific Transcription Factor Binding Sites, In Silico Biology, 4, 33.
57. H. Liu, L. Li, A. Zilberstein and C. Hahn. 2004.
Segmental Duplication Containing Tandem Repeated Genes Encoding Putative Deubiqitinating Enzymes.

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IEEE Computational Systems Bioinformatics Proceedings, pg. 31-39.
58. H. Liu, N. Ge, K. Yu, D. Krolikowski, A. Zilberstein and C. S. Hahn. 2004. Prediction of IFN-γ Regulated Gene
Transcription. In silico Biology 4: 0041.
59. W. Cao, C. Epstein, H. Liu, C. DeLoughery, N. Ge, J. Lin, R. Diao, H. Cao, F. Long, X. Zhang, Y. Chen, P.S.
Wright, S. Busch, M. Wenk, K. Wong, A.G. Saltzman, Z. Tang, L. Liu and A. Zilberstein. 2004. Comparing Gene
Discovery from Affymetrix GeneChip Microarrays and Clontech PCR-Select cDNA Subtraction: a Case Study.
BioMed Central Genomics, 5, 26.
60. W. Cao, Y. Chen, S. Alkan, A. Subramaniam, F. Long, H. Liu, R. Diao, T. Delohery, J. McCormick, R. Chen,
D. Ni, P. S. Wright, X. Zhang, S. Busch and Zilberstein. Human T Helper (Th) Cell Lineage Commitment is not
Directly Linked to the Secretion of IFN-γ or IL-4 : Characterization of The Cells Isolated by FACS based on IFN-γ
and IL-4 Secretion. 2005. Eur. J. Immunol. 35, 2709-2717.

5. PAGE 5 OF 6 ASHER ZILBERSTEIN, PHD
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BOOK CHAPTERS
1. M. Revel, J. Content, A. Zilberstein, H. Berissi, B. Lebleu, E. Falcoff and R. Falcoff (1975). Mechanism of the
Interferon-Induced Block of mRNA Translation in Mouse L-cells. In: Effects of Interferon on Cells, Viruses and
the Immune System, pp. 523-547 (A. Geraldes, ed.) Academic Press, NY.
2. M. Revel, J. Content, A. Zilberstein, B. Lebleu, E. Falcoff and R. Falcoff (1975). Mechanism of Interferon-
Induced Blocks of mRNA Translation. In: Perspectives in Virology, Vol. IX, pp. 233-248, Academic Press, NY.
3. M. Revel, J. Content, A. Zilberstein, U. Nudel, H. Berissi and B. Dudock (1975). Control of mRNA Translation
by Specific tRNAs in Extracts from Interferon-Treated Mouse Cells. In: In Vitro Transcription and Translation of
Viral Genomes. INSERM 47, 397-406.
4. M. Revel, E. Gilboa, A. Kimchi, A. Schmidt, L. Shulman, E. Yakobson and A. Zilberstein (1977). Proceedings of
the 11th FEBS Meeting, Copenhagen, Vol. 43, pp. 47-58, Pergamon Press, Oxford.
5. M. Revel, A. Schmidt, L. Shulman, A. Zilberstein and A. Kimchi (1978). The Regulation of Protein Synthesis by
Interferon. Proceedings of the 12th FEBS Meeting. Dresden, Vol. 51, pp. 415-426, Pergamon Press, Oxford.
6. M. Revel, A. Kimchi, A. Schmidt, L. Shulman and A. Zilberstein (1979). The Interferon System: Studies on the
Molecular Mechanism of Interferon Action. In: The Molecular Biology of Picornaviruses, pp. 239-253 (R. Perez-
Bercoff, ed.), Plenum Publishing Co.
7. H.F. Lodish, A. Zilberstein, G.J.A.M. Strous, M. Porter and M. Boucher (1980). Synthesis and Maturation of the
Vesicular Stomatitis Virus Glycoprotein. In: Biosynthesis, Modification and Processing of Cellular and Viral
Polyproteins, pp. 111-125 (G. Koch and D. Richter, eds.), Academic Press, NY.
8. H.F. Lodish, A. Zilberstein and M. Porter (1981). Synthesis and Assembly of Vesicular Stomatitis Virus and
Sindbis Virus Glycoproteins. In: Perspectives in Virology, Vol. XI, pp. 31-55 (M. Pollard, ed.), Alan R. Liss, Inc.
NY.
9. H.F. Lodish, W.A. Braell, A.L. Schwartz, G.J.A.M. Strous and A. Zilberstein (1981). Synthesis and Assembly of
Membrane and Organelle Proteins. In: Membrane Research, Classic Origins and Current Concepts. (Dedicated
to J.F. Danielli) International Reviews of Cytology, Supplement 12, pp. 247-307
(A.L. Muggleton-Harris, ed).
10. H.F. Lodish, A. Zilberstein and M. Porter (1981). Synthesis and Assembly of Transmembrane Viral and Cellular
Glycoproteins. In: Methods in Cell Biology, Vol. 23. Basic Mechanisms of Cellular Secretion, pp. 5-25.
Academic Press, NY.
11. A. Zilberstein and H.F. Lodish (1981). Synthesis and Assembly of the Vesicular Stomatitis Virus Glycoprotein
and Related Glycoproteins. In: Membranes and Transport: Vol. 1, pp. 219-236 (A. Martonosi, ed.). Plenum
Press, NY.
12. A. Zilberstein, M.D. Snider and H.F. Lodish (1982). Synthesis and Assembly of the Vesicular Stomatitis Virus
Glycoprotein. Cold Spring Harbor Symposia on Quant. Biol., Vol. 46, pp. 785-795.
13. Y. Mory, S.I. Feinstein, Y. Chernajovsky, U. Nir, A. Zilberstein and M. Revel (1981). Studies on New IFN-β
Genes in Human Cells. Proceedings of the 2nd Annual International Congress for Interferon Research.
14. A. Zilberstein, R. Ruggieri and M. Revel (1985). Human Interferon-β2: Is it an Interferon Inducer? In: the
Interferon System, Serono Symposia, Vol. 24, pp. 73-83. (G.B. Rossi and E. Dianzani, eds.) Raven Press, New
York.
15. M. Revel, R. Ruggieri and A. Zilberstein (1986). Expression of Human IFN-β2 Genes in Rodent Cells. In: The
Biology of the Interferon System 1985, pp. 207-216. (H. Schellekens and W.E. Stewart II, eds.) Elsevier Press,
Amsterdam.
16. A. Zilberstein, A. Nissim, R. Ruggieri, L. Shulman, L. Chen and M. Revel (1986). The Mode of Action of Human
Interferon-β2. In: The Biology of the Interferon System 1985, pp. 119-124. (H. Schellekens and W.E. Stewart II,
eds.) Elsevier Press, Amsterdam.
17. A. Zilberstein, R. Ruggieri, J.H. Korn, L. Chen, Y. Mory, J. Chebath, L. Shulman and M. Revel (1987).
Biological Activities of Human Interferon-β2 Produced by cDNA Expression in Hamster Cells and Possible
Autocrine Functions of this Cytokine-Induced IFN. In: The Biology of the Interferon System 1986, pp. 165-171 (K.
Cantel and H. Schellekens, eds.).
18. J. Sanceau, R. Falcoff, A. Zilberstein, F. Beranger and C. Vaquero (1987). Interferon Beta-2 is Constitutively
Expressed in Human Monocytes. In: The Biology of the Interferon System 1986, pp. 153-158 (K. Cantell and
H. Schellekens, eds.).

6. PAGE 6 OF 6 ASHER ZILBERSTEIN, PHD
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19. M. Revel, A. Zilberstein, R. Ruggieri, L. Chen, Y. Mory, M. Rubinstein and R. Michalevicz 1988a). Human IFN-
beta-2: a Cytokine with Multiple Functions in Infections and Inflammation. In: Monokines and Other Non-
Lymphocytic Cytokines, Progress in Leukocyte Biology. Vol. 8, pp. 21-27 (M.C. Powanda et al. eds.). A.R. Liss.
NY.
20. M. Revel, A. Zilberstein, R. Ruggieri, L. Chen, Y. Mory, M. Rubinstein and R. Michalevicz (1988b). Human IFN-
Beta-2: A Multifunctional Cytokine. In: Tumor Necrosis Factor, Cachetin and Related Cytokines, pp. 252-258
(H. Kirchner, B. Bonavida and L. Old, eds.). S. Karger, Basel.
21. M. Revel, L. Chen, Y. Mory, A. Zilberstein and R. Michalevicz (1989). Interferon-Type and Other Activities of
IFN-β-2/BSF-2/HSF. In: Advances in Immunopharmacology. Vol. 4, pp. 175-183. (J.W. Hadden et al. eds.)
Pergamon Press.
22. M. Revel, A. Zilberstein, L. hen, Y. Gothelf, I. Barash, D. Novick, M. Rubinstein and R. Michalevicz (1989).
Biological Activities of Recombinant Human IFN-β-2/IL-6 (E. coli). In: Regulation of the Acute Phase and
Immune Responses: Interleukin-6. Annals of the New York Academy of Sciences, Vol. 557, pp. 144-156 (P.B.
Sehgal, G. Grieninger and G. Tosato eds.).
GRANTED PATENTS (SELECTED)
1. Tyrosine Kinase Inhibitor Composition for Treating Bone Disease and Inflammation - Contains Compounds
Having Bis Ring System Comprising Aryl Ring and Aryl-, Carbocyclic- or Heterocyclic- Ring.
2. Chin-Yi Jenny Hsu, Susan Johnson, Martin Maguire, Michael R. Myers, Paul E. Persons, Alfred Spada and
Asher Zilberstein. U.S. Patent No. 5,480,883; Issued Apr. 19, 1994.
3. Aryl and Heteroaryl Quinazoline Compounds which Inhibit CSF-1 Receptor Tyrosine Kinase.
Michael R. Myers, Alfred P. Spada, Martin Maguire, Paul E. Persons, Asher Zilberstein, Chin-Yi Jenny Hsu and
Susan E. Johnson. U.S. Patent No. 5,714,493; Issued Feb. 3, 1998.
4. New Composition Containing Human Interferon - beta 2A for Treating Inflammation and Acute Phase Response.
Michel Revel and Asher Zilberstein. European Patent No. 536520; Issued Apr. 14, 1993.
5. Highly Purified Human Interferon Preparation - by Genetic Engineering of Bacterial Strain with Cloned Interferon
DNA. Michel Revel, P. Tiollais and Asher Zilberstein. U.S. Patent No. 5,468,607; Issued Jan. 21, 1995.
6. A DNA Sequence Encoding Active Interferon - beta 2A - Used in the Production of the Protein for the Treatment
of Cancer, by Inhibition of Fibroblast Proliferation. Michel Revel and Asher Zilberstein. European Patent No.
645452; Issued March 29, 1995.
7. Recombinant Human Interferon - beta 2A and beta 2B - Useful for Inflammation, Acute Phase Response or
Regulation of Cell Proliferation. Michel Revel, Asher Zilberstein and P. Tiollais. U.S. Patent No. 5,510,472;
Issued Apr. 23, 1