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glass as pharmaceutical packaging material
1.
2. ⢠Glass is an amorphousamorphous solid material which is
usually brittlebrittle and optically transparentoptically transparent.
⢠Glass is composed of sand, soda ash, cullet,
silicon, aluminum, boron, potassium, zinc etc.
3. ⢠Pharmaceutical container is defined as a device
that holds the pharmaceutical formulations and it
may or may not be in direct contact with the
formulation.
4. ⢠It must be neutral and not react with the materials
it is holding.
⢠It must maintain stability by resisting
environmental factors.
⢠It must be simply designed for dose withdrawal.
⢠The material must be resistance to temperature
and pressure of sterilization.
⢠Closure must be easily removable and replaced.
5. Glass is commonly used in pharmaceutical
packaging because it possesses:
⢠Superior protection
⢠Itâs economical
⢠Chemically inert
⢠Has FDA clearance
⢠Is an excellent barrier against practically all
elements
⢠Doesnât deteriorate with time
7. ďśHighly resistance glassHighly resistance glass, a substantial part of the
alkali and earth cations are replaced by boron
and/or aluminum and zinc.
ďśThe addition of about 6% boron6% boron to form
borosilicate glass reduces the leaching action, so
that only 0.5 ppm0.5 ppm is dissolved in a year.
ďśSuitable for parenteralparenteral usage.
8. ďśThis type of glass is formed by removal of surface
alkali by treatment with sulfur di-oxide,sulfur di-oxide,
ammonium sulfate or ammonium chlorideammonium sulfate or ammonium chloride to
prevent âweatheringâ or âbloomingâ.weatheringâ or âbloomingâ.
ďśThe glass is treated with the above said
chemicals at an elevated temperatureelevated temperature.
ďśThis makes the surface resistant and the alkali
removed appears on surface as blooms.
9. ďśContainers are made of untreated commercial
soda-lime glass.
ďśChemical resistance is average or better then
average.
ďśSuitable for storage of anhydrous parenteral
products.
10. ďśThese are made of plane soda- lime.
ďśThey are used for storage of oral and topical use.