SlideShare a Scribd company logo
1 of 51
Download to read offline
Dept. Microbiology, Medical Faculty Padjadjaran University VIROLOGY SUNARYATI SUDIGDOADI
[object Object],[object Object],[object Object],[object Object],[object Object],Introduction Virus :
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CHARACTERISTICS   ,[object Object],[object Object],[object Object],[object Object]
Viral Size ,[object Object],[object Object]
CHARACTERISTICS   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Virus structure & Morphology The basic design of all viruses places the nucleic  acid genome on the inside of a protein shell    capsid  Two basic types of virions : 1. Enveloped viruses        have a nucleocapsid of nucleic acid   complexed to protein   2. Naked capsid viruses      have a nucleic acid genome within a   protein shell
Virus structure & Morphology Schematic drawing of two basic type of virions
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basic viral forms
The structure and relative sizes of a number of DNA
The structure and relative sizes of a number of RNA
[object Object],[object Object],[object Object],[object Object],[object Object],DNA VIRUSES
RNA VIRUSES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
The main groups of human viruses
VIRAL REPLICATION Virus multiplication cycle consist of  6 phases : 1. Attachment/ adsorption to the host cell 2. Penetration or entry 3. Uncoating to release the genome 4. Virion component production/ synthesis 5. Assembly/ maturation 6. Release from the cells ,[object Object],[object Object],[object Object],[object Object]
The outcome of the infection depend on : the particular virus-host combination other factors : - the extracelullar environment - multiplicity of the infection - physiology & developmental state of the cell
ADSORPTION Adsorption is the first step in every viral infection. Adsorption involves : - virion attachment proteins - cell surface receptor proteins Examples of viral receptors
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Entry & Uncoating ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The two basic modes of entry of an enveloped animal virus  into the host cell
Entry by  direct fusion
Viropexis
Naked Capsid Animal Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Schematic of receptor-mediated endocytosis  ulitilized by poliovirus for entry into host cell
Insertion of  glycoprotein  into the cell’s  membrane structures  and formation of  the viral envelope
Viral release by Budding
VIRAL LIFE CYCLE ATTACHMENT PENETRATION HOST FUNCTIONS ASSEMBLY (MATURATION) Transcription REPLICATION RELEASE UNCOATING Translation MULTIPLICATION Click after each step to view process
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mechanisms of genetic change
Recombination Homologous recombination is common in DNA viruses   There are 2 mechanisms : 1. Which is unique to the viruses with segmented genomes, involves reassortment of the segments during a mixed infections involving 2 different viral strains. 2. Exemplified by the genetic recombination between  different forms of poliovirus Recombination occurs during replication by a “copy choice” type of mechanism Poliovirus replicase switches templates to generate recombinants
COMMON METHODS OF INACTIVATING VIRUSES FOR VARIOUS PURPOSE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cultivation in embryonated egg ,[object Object],[object Object]
 
Cultivation in cell cultures
Cultivation in cell culture ,[object Object],[object Object],[object Object],[object Object]
TRANSMISSION OF VIRAL INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS OF VIRAL DISEASES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DIAGNOSTIC METHODS OF VIRAL INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory diagnosis   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PREVENTION AND TREATMENT OF VIRAL INFECTIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2. INTERFERONS ,[object Object],[object Object],[object Object],[object Object],[object Object]
3. ANTIVIRAL CHEMOTHERAPY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
B. Nucleotide analogs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Questions ?

More Related Content

What's hot (20)

Viruses
VirusesViruses
Viruses
 
Poxvirus
PoxvirusPoxvirus
Poxvirus
 
Picornavirus
PicornavirusPicornavirus
Picornavirus
 
Viruses ppt
Viruses pptViruses ppt
Viruses ppt
 
Virus
VirusVirus
Virus
 
Rhabdo virus
Rhabdo virusRhabdo virus
Rhabdo virus
 
Virology
VirologyVirology
Virology
 
Introduction to Virology
Introduction to Virology Introduction to Virology
Introduction to Virology
 
Papova viruses
Papova virusesPapova viruses
Papova viruses
 
Reoviridae
ReoviridaeReoviridae
Reoviridae
 
Viral host interactions
Viral host interactionsViral host interactions
Viral host interactions
 
Chapter 1 introduction to virus
Chapter 1 introduction to virusChapter 1 introduction to virus
Chapter 1 introduction to virus
 
Viral structure & properaties
Viral structure & properatiesViral structure & properaties
Viral structure & properaties
 
Cultivation and assay of viruses
Cultivation and assay of virusesCultivation and assay of viruses
Cultivation and assay of viruses
 
Introduction to Viruses
Introduction to VirusesIntroduction to Viruses
Introduction to Viruses
 
Virology Lecture Note
Virology Lecture NoteVirology Lecture Note
Virology Lecture Note
 
Isolation and cultivation of animal and plant viruses
Isolation and cultivation  of animal and plant virusesIsolation and cultivation  of animal and plant viruses
Isolation and cultivation of animal and plant viruses
 
Animal viruses
Animal virusesAnimal viruses
Animal viruses
 
Medical Virology: by ORIBA DAN LANGOYA
Medical Virology: by ORIBA DAN LANGOYAMedical Virology: by ORIBA DAN LANGOYA
Medical Virology: by ORIBA DAN LANGOYA
 
DNA VIRUS REPLICATION
DNA VIRUS REPLICATIONDNA VIRUS REPLICATION
DNA VIRUS REPLICATION
 

Viewers also liked

Viewers also liked (20)

Virology lecture 1 introduction
Virology lecture 1 introductionVirology lecture 1 introduction
Virology lecture 1 introduction
 
Virology
VirologyVirology
Virology
 
Molecular Genetics of Host-Virus Interactions
Molecular Genetics of Host-Virus InteractionsMolecular Genetics of Host-Virus Interactions
Molecular Genetics of Host-Virus Interactions
 
Viruses
VirusesViruses
Viruses
 
Virus & virus like organisms
Virus & virus like organismsVirus & virus like organisms
Virus & virus like organisms
 
Herpetic skin infections
Herpetic skin infectionsHerpetic skin infections
Herpetic skin infections
 
Herpes Simplex RC
Herpes Simplex RCHerpes Simplex RC
Herpes Simplex RC
 
Virology week6
Virology week6Virology week6
Virology week6
 
Rabies, Rhabdoviridae
Rabies, RhabdoviridaeRabies, Rhabdoviridae
Rabies, Rhabdoviridae
 
Rhabdoviridae ppt
Rhabdoviridae pptRhabdoviridae ppt
Rhabdoviridae ppt
 
Rhabdovirus
RhabdovirusRhabdovirus
Rhabdovirus
 
Rhabdoviridae
RhabdoviridaeRhabdoviridae
Rhabdoviridae
 
Virology Review
Virology ReviewVirology Review
Virology Review
 
Classification of virus
Classification of virusClassification of virus
Classification of virus
 
Disease State Presentation: Herpes Simplex Virus
Disease State Presentation: Herpes Simplex VirusDisease State Presentation: Herpes Simplex Virus
Disease State Presentation: Herpes Simplex Virus
 
Virology
VirologyVirology
Virology
 
Virology
VirologyVirology
Virology
 
33. introduction to virology
33. introduction to virology33. introduction to virology
33. introduction to virology
 
Pathogenesis Virus
Pathogenesis VirusPathogenesis Virus
Pathogenesis Virus
 
An introduction to virology
An introduction to virologyAn introduction to virology
An introduction to virology
 

Similar to Virology Dr.Titi

generalpropertiesofviruses-140309015013-phpapp02.pdf
generalpropertiesofviruses-140309015013-phpapp02.pdfgeneralpropertiesofviruses-140309015013-phpapp02.pdf
generalpropertiesofviruses-140309015013-phpapp02.pdfOsmanAli92
 
General properties of viruses
General properties of virusesGeneral properties of viruses
General properties of virusesraghunathp
 
Chapter+5,+25,+37 (microbiology) 8th edition
Chapter+5,+25,+37 (microbiology) 8th editionChapter+5,+25,+37 (microbiology) 8th edition
Chapter+5,+25,+37 (microbiology) 8th editionAreej Abu Hanieh
 
virology level 3 taiz lecture university 1 .pptx
virology level 3 taiz lecture university 1 .pptxvirology level 3 taiz lecture university 1 .pptx
virology level 3 taiz lecture university 1 .pptxssuser9976be
 
Lect virology.pptx
Lect virology.pptxLect virology.pptx
Lect virology.pptxsaad510479
 
Presentation 0n virus (09 12-2014)
Presentation 0n virus (09 12-2014)Presentation 0n virus (09 12-2014)
Presentation 0n virus (09 12-2014)Asraful Islam Rayhan
 
33. an introduction to the viruses
33. an introduction to the viruses33. an introduction to the viruses
33. an introduction to the virusessulochan_lohani
 
Morphology and physiology of viruses
Morphology and physiology of virusesMorphology and physiology of viruses
Morphology and physiology of virusesBabar Joya
 
Viruses-definition, classification, replication, cultivation of viruses
Viruses-definition, classification, replication, cultivation of virusesViruses-definition, classification, replication, cultivation of viruses
Viruses-definition, classification, replication, cultivation of virusessomeshwar mankar
 
7.-Virology.pdf
7.-Virology.pdf7.-Virology.pdf
7.-Virology.pdfmetti007
 
Chapter 13 Viruses, Viroids, and Prions
Chapter 13 Viruses, Viroids, and PrionsChapter 13 Viruses, Viroids, and Prions
Chapter 13 Viruses, Viroids, and Prionsrmasterson
 
Virology. Structure of Viruses. Methods of cultivation
Virology. Structure of Viruses. Methods of cultivationVirology. Structure of Viruses. Methods of cultivation
Virology. Structure of Viruses. Methods of cultivationEneutron
 

Similar to Virology Dr.Titi (20)

generalpropertiesofviruses-140309015013-phpapp02.pdf
generalpropertiesofviruses-140309015013-phpapp02.pdfgeneralpropertiesofviruses-140309015013-phpapp02.pdf
generalpropertiesofviruses-140309015013-phpapp02.pdf
 
General properties of viruses
General properties of virusesGeneral properties of viruses
General properties of viruses
 
Basic virology (a.3)
Basic virology (a.3)Basic virology (a.3)
Basic virology (a.3)
 
Chapter+5,+25,+37 (microbiology) 8th edition
Chapter+5,+25,+37 (microbiology) 8th editionChapter+5,+25,+37 (microbiology) 8th edition
Chapter+5,+25,+37 (microbiology) 8th edition
 
Micro Ch13 Edited
Micro Ch13  EditedMicro Ch13  Edited
Micro Ch13 Edited
 
virology level 3 taiz lecture university 1 .pptx
virology level 3 taiz lecture university 1 .pptxvirology level 3 taiz lecture university 1 .pptx
virology level 3 taiz lecture university 1 .pptx
 
Lect virology.pptx
Lect virology.pptxLect virology.pptx
Lect virology.pptx
 
Presentation virus (09 12-2014)
Presentation virus (09 12-2014)Presentation virus (09 12-2014)
Presentation virus (09 12-2014)
 
Presentation 0n virus (09 12-2014)
Presentation 0n virus (09 12-2014)Presentation 0n virus (09 12-2014)
Presentation 0n virus (09 12-2014)
 
33. an introduction to the viruses
33. an introduction to the viruses33. an introduction to the viruses
33. an introduction to the viruses
 
Viruses general properties
Viruses general propertiesViruses general properties
Viruses general properties
 
Morphology and physiology of viruses
Morphology and physiology of virusesMorphology and physiology of viruses
Morphology and physiology of viruses
 
Virus.ppt
Virus.pptVirus.ppt
Virus.ppt
 
Viruses-definition, classification, replication, cultivation of viruses
Viruses-definition, classification, replication, cultivation of virusesViruses-definition, classification, replication, cultivation of viruses
Viruses-definition, classification, replication, cultivation of viruses
 
7.-Virology.pdf
7.-Virology.pdf7.-Virology.pdf
7.-Virology.pdf
 
Chapter 13 Micro
Chapter 13 MicroChapter 13 Micro
Chapter 13 Micro
 
1.Medical Virology PH 2022.pptx
1.Medical Virology PH 2022.pptx1.Medical Virology PH 2022.pptx
1.Medical Virology PH 2022.pptx
 
1.Medical Virology PH 2022.pptx
1.Medical Virology PH 2022.pptx1.Medical Virology PH 2022.pptx
1.Medical Virology PH 2022.pptx
 
Chapter 13 Viruses, Viroids, and Prions
Chapter 13 Viruses, Viroids, and PrionsChapter 13 Viruses, Viroids, and Prions
Chapter 13 Viruses, Viroids, and Prions
 
Virology. Structure of Viruses. Methods of cultivation
Virology. Structure of Viruses. Methods of cultivationVirology. Structure of Viruses. Methods of cultivation
Virology. Structure of Viruses. Methods of cultivation
 

Recently uploaded

Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Adtran
 
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfIaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfDaniel Santiago Silva Capera
 
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPA
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPAAnypoint Code Builder , Google Pub sub connector and MuleSoft RPA
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPAshyamraj55
 
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdf
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdfUiPath Solutions Management Preview - Northern CA Chapter - March 22.pdf
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdfDianaGray10
 
Empowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintEmpowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintMahmoud Rabie
 
Videogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfVideogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfinfogdgmi
 
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...DianaGray10
 
9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding TeamAdam Moalla
 
Comparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioComparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioChristian Posta
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1DianaGray10
 
Basic Building Blocks of Internet of Things.
Basic Building Blocks of Internet of Things.Basic Building Blocks of Internet of Things.
Basic Building Blocks of Internet of Things.YounusS2
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UbiTrack UK
 
Igniting Next Level Productivity with AI-Infused Data Integration Workflows
Igniting Next Level Productivity with AI-Infused Data Integration WorkflowsIgniting Next Level Productivity with AI-Infused Data Integration Workflows
Igniting Next Level Productivity with AI-Infused Data Integration WorkflowsSafe Software
 
Introduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxIntroduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxMatsuo Lab
 
Nanopower In Semiconductor Industry.pdf
Nanopower  In Semiconductor Industry.pdfNanopower  In Semiconductor Industry.pdf
Nanopower In Semiconductor Industry.pdfPedro Manuel
 
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDEADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDELiveplex
 
How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?IES VE
 
UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8DianaGray10
 
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfJamie (Taka) Wang
 

Recently uploaded (20)

Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™
 
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfIaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
 
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPA
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPAAnypoint Code Builder , Google Pub sub connector and MuleSoft RPA
Anypoint Code Builder , Google Pub sub connector and MuleSoft RPA
 
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdf
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdfUiPath Solutions Management Preview - Northern CA Chapter - March 22.pdf
UiPath Solutions Management Preview - Northern CA Chapter - March 22.pdf
 
Empowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintEmpowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership Blueprint
 
Videogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfVideogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdf
 
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
 
9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team
 
Comparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioComparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and Istio
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1
 
Basic Building Blocks of Internet of Things.
Basic Building Blocks of Internet of Things.Basic Building Blocks of Internet of Things.
Basic Building Blocks of Internet of Things.
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
 
Igniting Next Level Productivity with AI-Infused Data Integration Workflows
Igniting Next Level Productivity with AI-Infused Data Integration WorkflowsIgniting Next Level Productivity with AI-Infused Data Integration Workflows
Igniting Next Level Productivity with AI-Infused Data Integration Workflows
 
Introduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxIntroduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptx
 
20230104 - machine vision
20230104 - machine vision20230104 - machine vision
20230104 - machine vision
 
Nanopower In Semiconductor Industry.pdf
Nanopower  In Semiconductor Industry.pdfNanopower  In Semiconductor Industry.pdf
Nanopower In Semiconductor Industry.pdf
 
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDEADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
 
How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?
 
UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8
 
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
 

Virology Dr.Titi

  • 1. Dept. Microbiology, Medical Faculty Padjadjaran University VIROLOGY SUNARYATI SUDIGDOADI
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.  
  • 8. Virus structure & Morphology The basic design of all viruses places the nucleic acid genome on the inside of a protein shell  capsid Two basic types of virions : 1. Enveloped viruses  have a nucleocapsid of nucleic acid complexed to protein 2. Naked capsid viruses  have a nucleic acid genome within a protein shell
  • 9. Virus structure & Morphology Schematic drawing of two basic type of virions
  • 10.
  • 12. The structure and relative sizes of a number of DNA
  • 13. The structure and relative sizes of a number of RNA
  • 14.
  • 15.
  • 16.  
  • 17.  
  • 18. The main groups of human viruses
  • 19.
  • 20. The outcome of the infection depend on : the particular virus-host combination other factors : - the extracelullar environment - multiplicity of the infection - physiology & developmental state of the cell
  • 21. ADSORPTION Adsorption is the first step in every viral infection. Adsorption involves : - virion attachment proteins - cell surface receptor proteins Examples of viral receptors
  • 22.
  • 23.
  • 24. The two basic modes of entry of an enveloped animal virus into the host cell
  • 25. Entry by direct fusion
  • 27.
  • 28. Schematic of receptor-mediated endocytosis ulitilized by poliovirus for entry into host cell
  • 29. Insertion of glycoprotein into the cell’s membrane structures and formation of the viral envelope
  • 30. Viral release by Budding
  • 31. VIRAL LIFE CYCLE ATTACHMENT PENETRATION HOST FUNCTIONS ASSEMBLY (MATURATION) Transcription REPLICATION RELEASE UNCOATING Translation MULTIPLICATION Click after each step to view process
  • 32.
  • 33. Recombination Homologous recombination is common in DNA viruses There are 2 mechanisms : 1. Which is unique to the viruses with segmented genomes, involves reassortment of the segments during a mixed infections involving 2 different viral strains. 2. Exemplified by the genetic recombination between different forms of poliovirus Recombination occurs during replication by a “copy choice” type of mechanism Poliovirus replicase switches templates to generate recombinants
  • 34.
  • 35.  
  • 36.
  • 37.  
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49.  
  • 50.