This slideshow is to educate people that the Best Calcium Supplement is actually Calmodulin (CaM), which is the trasporter and regulator for Calcium ions to go into the cells. Without CaM, calcium cannot be absorped into the cell which leads to calcium defiency. Serious calcium defiency will cause osteopenia and even osteoporosis. Too much of calcium causes calcification. Therefore, calcium needs to be regulated and balanced by Calmodulin.

2. Bone loss is primarily due to Bone Remodeling Process, Unchangeable risk
factors such as gender, body size and etc, and changeable risk factors such
as coffee consumption and lack of exercises.
What is Bone Remodeling? Basically there are 2 types of bone cells.
Osteoclast which destroys worn out cells (Resorption) so that Osteoblast
can regenerate new bone cells. This is how the bone remodeling process
works.
However, after the age of 30, things changed. The number of Osteoclasts
increases and they tend to work more aggressively destroying old and worn
out cells. On the other hand, Osteoblasts become inactive or rather they
work slower. Their efficiency of making new bone cells decreases. This
means that they cannot replenish the bone faster than the Osteoclasts
destroying the bone cells.
Therefore, after the age of 30, bone tends to become porous which leads to
Osteopenia and even Osteoporosis. Coupled with some unchangeable and
changeable risk factors, it makes bone degradation becomes even faster.

3. Bone Remodeling
Wear & Tear
Osteoclast
Osteoblast
Healthy Bone
One cycle of bone remodeling process: 4 months

4. Bone Loss Increase After the Age of 30
Wear & Tear
Osteoclast
Osteoblast
Osteoporosis
↑Bone Fracture Risk

5. Unchangeable Risk Factors
Female
Aging
Caucasian &
Asian
Tiny Body
SizeFamily History

6. Changeable Risk Factors

7. In human body, 99%
of CALCIUM is stored
in bone and teeth
Ca
Ca
Ca
Ca
Ca
Ca Ca
Ca
Another 1% is stored
in blood
So, the 99% or the 1% is important?

8. Answer is BOTH!
99% of CALCIUM forms human skeletal system, which without it we can’t even
stand, sit or move. Don’t forget, blood cells are made from BONE too!
Another 1%, though it’s minute, the roles it plays are MAGNIFICIENT!
Because this 1% helps in:
Activate Enzyme System
Activeness and Production
of Cell
Maintain heartbeat and
muscle contraction
Maintain Cell Membrane
Permeability and Stability
Regulating Nervous System
(Signal Transduction)
Normalize Immune System
Promote Hormone Secretion
Promote Blood Clotting

9. However, it has to be
balanced. Because -
According to WHO’s statistic, 106 in 135
recorded human common diseases are
related to imbalance calcium metabolism.

10. In the case
of
CALCLIUM
deficiency
Mild Moderate Severe
Insomnia Osteoporosis Children growth
retardation
Muscle cramps Chronic backache Rickets
Loss of appetite Hunchback Osteomalacia
Irritability Arrhythmia Colon cancer
Tension Hormone imbalance Difficulty in breathing
Hypotension Decreased liver
function
Mental disorder
Hypertension Drop of teeth Bone deformation
Brain sluggish Height reduction Heart failure
Decrease resistance “O” shape leg Bone fracture
Congestion Aching of waist & leg
Allergy Cardiac dysfunction
Lack of energy Pulse disturbance
Extremities numbness Joint pain

11. The Deficiency of Calcium
OSTEOPOROSIS
MUSCULAR
ATROPHY
ARTHRITIS
They are interconnected and are
due to Calcium Deficiency!

12. In the case of too much
CALCIUM where it causes HYPERCALCEMIA
◎Diabetes Mellitus
◎Alzheimer’s disease
◎Hypertension
◎Arteriosclerosis
◎Stroke
◎Extremities numbness
◎Heart numbness
◎Calcification
◎Kidney stone
◎Cataract
◎Cell degeneration & death
◎Deterioration of disease

13. Consuming Calcium & Vitamin D doesn't help
in preventing Bone Fracture

14. United States
New Zealand
Most of the Americans and New
Zealanders drink milk, take Calcium
supplements everyday and have
exposure to sunshine. Why are they
having the highest pelvic fracture rate?

16. The Passage of Calcium Absorption
Calcium in Food
50% Stomach
Small Intestine (SI)
Calcium in Bone
細胞 Cell
1%
99%
20%
ParathyroidHormone
Diagram: Digestive system
Blood
From food, Ca goes through digestive tract. 50% of Ca destroyed by stomach acid,
remaining 50% to small intestine. From SI, 20% of Ca goes into blood. 1% of it
stored in blood. 99% to bone cells. For this 99% to go into bone, CaM is needed.
Calmodulin (CaM)
CELL

17. The Key Concept for Calcium
Absorption into Cell
Glucose
Extracellular Intracellular
Insulin
細胞内
Calcium
Calmodulin (CaM)
細胞外
Extracellular Intracellular

18. Calmodulin -- Calcium Modulated Protein
There are more than 1.8 million papers and thesis on Calmodulin
http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=960033643&_sort=r&view=c
&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4714340e36664b88c4cd52470b60699f

19. Calmodulin
Calcium Binding Protein
Ca
Ca
Ca
Ca
One Calmodulin has
four binding sites. In
other words, each
Calmodulin combines
with 4 Calcium ions and
brings them into cells
one short.

20. CaMsecretion
100%
50%
5歲 10歲 20歲 30歲 40歲 50歲 60歲 70歲 80歲
Cerebellum Cell
Digestive Cell
Reproductive Cell
Age
CaM secretion reduced after 30 years old which
leads to degradation of the functions of different
organs.
Calcium can be found from a variety of food, eg milk, soy bean,
vegetables and etc.
As CaM is a natural protein that is being synthesized from human body,
we cannot get it from food.
20 30 40 50 60 70 80105
Age

21. Fortunately there is Professor Wang Kai-Wah, who discovered CaM in
1972 while she was doing cancer researches. Since then, researches as
well as clinical trials on CaM was done on mice, monkeys and cancer
patients by her.
We cannot get CaM from food but luckily we have Professor Wang Kai-
Wah who made it into edible health food.
CaM is produced by single cell culture through Biotechnology. It is formed
by 148 amino acids, including both Essential and Non-essential. This
formula is not enough as 50% of any food that goes through digestive tract
will be destroyed by stomach acid. Therefore, Lecithin is used to cover the
combination, so that Ca2+ - CaM complex can be protected from
destruction at stomach and reaches cell where it is then be absorbed fully.

22. Specialize in immunology, cytology, bioengineering & oncology
research
Professor Wang Kai-Wah
1954 - Graduated from Beijing Medical University
1958 - Participated in the study of the insulin synthesis
1972 - Involved in tumor-associated antigen and skin test for cancer and discovered
Calmodulin
1982 - Professor at the School of Medicine, Xiamen University, and as the
chairperson of Xiamen Cancer Research Centre
1990 - Established the Bionike Laboratory in America, which specialize
in the research and development of bioengineering technologies as
well as the production of medical supplies.
Worldwide well-known Bioengineering Professor
Recipient of 9 state Technological Invention Awards (China)
FIRST & ONLY Professor who Successfully
turns CaM into product &
undergo 20 years of clinical trials

23. + Cell
+
_
+
++
+
+
+
_ _
_
_
_
_
_
World’s Leading Bioengineering Technology
CaCa
CaCa
CaM
Single cell culture  formed by 148 amino
acids  chelated with 4 Ca2+
Uniqueness 1
_ +
+
_

24. Essential Amino Acid Non-essential Amino Acid
Essential
Amino Acids
are amino
acids that
cannot be
produced from
body and ought
to get from food.
Non-essential
Amino Acids
are amino
acids that can
be produced
from human
body.
CaM
contains both
Essential
and Non-
essential
Amino Acids.
Add up all the
numbers
indicated after
each amino acid
and you shall get
148. CaM is
made up of 148
amino acids.

25. + Cell
+
_
+
++
+
+
+
_ _
_
_
_
_
_
World’s Leading Bioengineering Technology
CaCa
CaCa
CaM
Covered by lecithin  prevent stomach acid
destruction  reach small intestine safely 
electrogenically  more than 90% direct absorption
_ +
+
_
Uniqueness 2

26. 1. Bi-directional regulation of Ca2+
concentration
Coordination of the nervous system
and endocrine system
Energy starter and activation of
enzyme system
Promote the regeneration of cells
Regulate immune function

27. 0.69650.6678
1. CaM = Bi-directional regulation of Ca2+ concentration (Calcium
replacement in the case of Calcium Deficiency)
DEXA scan shows Bone Mineral Density increases.
Some gaps were filled after 4 months consumption of
CAM.

28. 1.527 1.307
DEXA Scan shows calcification reduces in which excess
calcified calcium is being removed, which leads to
decreased Bone Mineral Density (BMD closer to ideal
0.995) after 4 months consumption of CAM.
1. CaM = Bi-directional regulation of Ca2+ concentration (removes
excess calcified Calcium in the case of Calcification)

29. Osteoporosis & bone spur BMD ↑11% & bone spur
become smaller
1. CaM = Bi-directional regulation of Ca2+ concentration (removes
excess Calcium growth in the case of Bone Spur)

30. Before use of CAM
After use of CAM
This Taiwanese old lady has 90o
hunchback that causes stomach bleeds
due to compression. The effort of
inserting endoscope was finally done
after 21 attemps.
CaM does not magically turn her bone to straight. But rather, CaM helps in
replenishing Ca into bone that makes her bone becomes stronger. As bone
becomes stronger, it has the strength to support body weight and she can
stand up straight. Or else, weak bones tend to be crooked and cause
hunchback and arthritis.
Mdm Lin Age: 70+
1. CaM = Bi-directional regulation of Ca2+ concentration (Calcium
replacement in the case of Calcium Deficiency)

31. Coordination of the nervous system and
endocrine system
CaM helps in regulating nervous system where spine and leg
soreness and pain experienced due to severe loss of Calcium can
be relieved.
Signal transduction in neurons requires Calcium. Some nervous
system diseases such as Alzheimer’s and Parkinson’s Disease
are due to insufficient Calcium in neurons which leads to improper
signal transduction. Supplementing Calmodulin to ensure that
Calcium is being absorbed into cell helps in activating signal
transduction which in turn, alleviate Alzheimer’s and Parkinson’s
Disease symptoms.
As CaM helps in regulating endocrine system, diseases caused by
hormone imbalance such as diabetes, obesity and even
pigmentation and black spots especially during menopause could
also be alleviated.

32. Coordination of the nervous system and
endocrine system
Before use of CAM After use of CAM
This lady from Sarawak, Malaysia suffered from facial stroke for 38
years.
CaM helps in regulating nervous system. Signal transduction in
neurons was well regulated after consumption of CAM for almost a
year that loosen up of facial muscle as shown above. Her limbs and
legs joint pain have been reduced. Her speech became clearer too.
Mdm Agnes Siah Age : 70

33. Energy starter and activation of enzyme system
CaM helps in activating mitochondria and enhancing ATP generation.
Besides, CaM also enhances S.O.D enzyme to remove free radicals.
Act as an energy starter, CaM enhances vitality.
As CaM activates a series of biochemical reactions in body by
activating enzyme system. This improves gastrointestinal tract (GIT)
function and increase cell metabolic rate.
E.CaM.Ca2+
A + B C
Biochemical
Reaction
CaM . Ca2+
E = Enzyme
CELL

34. 4. Promote the
regeneration of cells

35. Cell division (phase M) – the important regulator - CaMK-II
The CaMK-II protein level was
unchanged during the cell
cycle. When the cells were
synchronized, the autonomous
activity was increased only in
M.
These results indicate that the
physiologically relevant portion
of CaMK-II is activated only in M,
and that the net activation of
CaMK-II is required in mitosis.

36. Activation of CaM during phase M in cell division
These data suggest that
calmodulin regulates
mitotic transitions.

37. CELLULITIS
RAPID WOUND
HEALING in 4
months time
Mdm Tsie from Taiwan
suffered from Cellulitis
due to a wound on her
foot. She was being
transferred from
hospital to hospital but it
does not seem to work
for her. After consuming
CAM, wound started to
heal. CaM activates
CaM K-II which
promotes cell
replication.
Before use
After use

38. The adult bone marrow stem cells
Inside the adult bone marrow, there are two types of stem cells,
Hematopoietic Stem Cell (HSC) & Mesenchymal Stem Cells (MSC).
HSC inside the bone marrow can differentiate into red blood cells,
white blood cells and platelets to maintain normal function of
blood. Besides, it can differentiate into lymphocytes and
macrophages to regulate immune function.
MSC was mainly found in bone marrow, can be found in cord
blood, peripheral blood and adipose tissue too. MSC can
differentiate into various type of cells, including osteoblasts,
chondrocytes, fat cells, muscle cells, etc. In addition, MSC can
support the hematopoetic process of HSC.

39. Calmodulin-dependent Protein Kinase IV regulates
Hematopoetic Stem Cell Maintenance

40. Mesenchymal stem cells (MSC)Mesenchymal stem cells (MSC)
Mesenchymal stem cells had been revealed in the US official journal – Science on
2nd April 1999.
Multilineage Potential of Adult
Human Mesenchymal Stem Cells
Science 284, 143 (1999)

41. Mesenchymal Stem Cell (MSC)
Bone marrow will be stimulated to release MSC when it
receives the signals from the injured tissues. MSC will
mobilize into circulation to the injured tissues and undergo
differentiation for tissue regeneration and healing in order
to maintain the constant number of body cells.

42. MAP kinase and calcium signaling mediate fluid flow-
induced human mesenchymal stem cell proliferation
The application of fluid flow also
induced the phosphorylation of
extracellular signal-regulated
kinase-1and -2 as well as the
activation of the calcium-
sensitive protein phosphatase
calcineurin in mesenchymal
stem cells.
Am J Physiol Cell Physiol 290: C776–C784, 2006.

43. Ca2+ . CaM complex and regeneration mechanism
CaM + Ca2+
CaM K-II
Mitosis
(Cell Replication/
Cell Division)
CaM K-IV
activates
promotes
Hematopoietic
Stem Cell
Synthesize
Blood Cells
activates
activates
promotes
Calcineurin in
Mesenchymal
Stem Cells
activates
Injured Part
Wound Healing
Process
to
Carry out
To summarize:
Without CaM, all these
biochemical reactions in
human body cannot be
carried out.

44. CaM + Ca2+
Analogy:
Ca2+ = Lock
CaM = Key
A key is needed to lock or unlock a lock. The key is like a
regulator. Likewise, CaM is the regulator for Ca2+.
Without CaM (the key), many of the biochemical reactions
in the human body cannot be carried out. Moreover, it is
to no avail if you have enough Ca2+ (Lock) but no CaM
(Key) to activate these series of biochemical reactions in
the body.
Frame of Life

45. Regulate immune function
CaM regulate immune function by activating macrophages .
Activated macrophages will engulf and destroy substances that
are harmful to the body, such as toxins and even tumour cells.
In addition, CaM also prevents tumour cells from obtaining
nutrients. Cancer patients often feel weak. Therefore, CAM is
essential for nutrients replacement especially for cancer
patients after they have done chemotherapy or radiotherapy.
CaM activates macrophages and helps in preventing cancer
and bacteria invasion, enhancing immune system and
eliminating age spots and lipomas.

46. Mr. Khor (on the left) from Kuala Lumpur, Malaysia suffered from
Prostate Cancer in 2007. He was recommended CAM by his doctor (on
the right). After consuming CAM, the PSA (Prostate-specific Antigen)
dropped from 130 to 0.4. He is still enjoying good health until now.
Age : 73Mr. Khor

47. CAM TM
ma-CAM TM

48. CAM TM
Basically contains Calmodulin, Skimmed Milk, Lecithin, American Ginseng
and Soybean Extract.
Please note that it is American Ginseng but not Ginseng. (Ginseng is
reported to be heaty and breast and ovarian cancer-causing). Soybean
Extract is without the outer layer that contains Purine. Therefore, it does not
affect Uric Acid, rather CaM regulates nervous system which reduces ache
and endocrine system which promotes balanced hormones.

49. ma-CAM TM
Basically contains Calmodulin, Millet, Lecithin, American Ginseng and Soybean
Extract. The Skimmed Milk in CAM is replaced with millet.
The amount of Calmodulin in ma-CAM is lesser but the binding affinity has
been improved by 30%. Therefore, it gives the same effect as CAM.
ma-CAM is to cater those with lactose intolerance or with chronic diseases for
eg, Hypertension, Diabetes, High Cholesterol, Uric Acid or Heart Diseases. It
is recommended for the elderly and vegetarians.

50. What are the differences
between CaM and Fosamax
since both of them are for
Calcium replacement?
Question:

51. References:
1. http://www.healthcentral.com/osteoporosis/c/73/8029/boniva-oral/
2. http://www.coreynahman.com/osteoporosis_pagets.html
Comparison Fosamax Actonel Boniva CAM and ma-
CAM
Category Drug Drug Drug Health Food
Side effects Affects stomach, liver and kidney. Jaw necrosis. Cancer. It’s food. No side
effects.
Dosage Once a week orally. Once a month orally.
Intravenous once in
3 months.
Can be taken daily
because it’s a food
that causes no side
effects.
Do’s and Don’ts Consume in a sitting or standing posture.
Cannot lie down within 30 mins after
consumption.
Consume in a sitting
or standing posture.
Cannot lie down
within 1 hr after
consumption.
No restrictions
whatsoever.
Effectiveness Only prevent Osteoclasts from destroying worn out cells
(Resorption). Do not activate Osteoblasts to regenerate new bone
cells. Even for Fosamax, it gives only 9% improvement in 3 years
time.
Normalize Bone
Remodeling Process.
Activate Osteoblasts
to regenerate new
bone cells. Proven
and testified by
thousands of CaM
consumers via Dexa
Scan.

52. Say NO to
OSTEOPOROSIS
Reminder:
It is insufficient to
consume supplement
alone without the
REGULATOR or
TRANSPORTER of
that nutrient. A lock
needs a key to be
locked or unlocked.

53. 1. Be careful when you walk 2. Carrying heavy things is not
recommended
4. Exercise
regularly
3. Hiking is not
recommended;
Be careful when
going up & down
the staircase

54. It’s a bit long but worth reading.
Best Wishes and
Thank You.