1. Collagen Biochemistry

3. Most of us are probably aware that collagen is a widely used cosmetic agent.

5. Collagen is the most abundant protein in the animal kingdom

6. Major collagen types

7. Collagen is essential for maintaining tissue integrity

8. What’s the proof?

10. Collagen biosynthesis Intracellular events

11. Collagen hierarchy

12. Intracellular processing

14. Extracellular processing

16. Ehlers Danlos Highly elastic skin In rare cases it can be fragile Chronic joint pain, joint laxity Scoliosis Increased risk of bone fracture Fragile blood vessels Mitral valve prolapse

17. Extracellular processing II Collagen cross-linking

20. Lathyritic agents underpin the critical importance of collagen cross-links  -aminoproprionitrile

22. Pyrrole & Pyridinium Cross-links