Foreign problems can provide new opportunities for innovation. Designing solutions for global health issues requires understanding how to effectively enable change. People and organizations are more likely to adopt changes if they see the problem as serious and feel the proposed solution will help, and if key supporters endorse the change. The design process involves discovering problems, making sense of their context, ideating solutions, prototyping ideas, refining them based on feedback, and continuously evaluating and evolving to drive further improvement. Sense-making requires considering problems and solutions within complex, interconnected systems.