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Spleen
1. Universidad de Guadalajara
Centro Universitario Ciencias de la Salud
Spleen
Giovanna Lazcano Sherman
Dr. Héctor Manuel Virgen Ayala
November 2011 Dr. Benjamín Robles Mariscal
2. Anatomy
Develops from
mesenchymal
cells in the dorsal
mesogastrium
during the fifth
week of gestation.
12. Cronic Lymphocytic
Leukemia
Is a B-cell leukemia that is
characterized by the
progressive accumulation
of relatively mature, but
functionally
incompetent, lymphocytes.
Splenectomy for palliation of symptomatic
splenomegaly and for treatment of cytopenia related to
hypersplenism
13. Hairy cell leukemia
Splenomegaly, pancytopenia
, and neoplastic
mononuclear cells in the
peripheral blood and bone
marrow
Administration of purine analogues, as initial
treatment. Splenectomy…massive enlargement
of the spleen or with evidence of hypersplenism.
14. Myelodysplastic
syndrome
The bone marrow is usually
replaced by fibrous tissue.
Splenectomy ...
* Hemolysis unresponsive to treatment.
* Symptoms esoplenomegalia graces of mass.
* Life-threatening thrombocytopenia.
16. Gaucher disease
Autosomal recessive disorder
caused by a deficiency of
beta-glucosidase.
(an enzyme that degrades the
sphingolipid
glucocerebroside)
Splenectomy for hypersplenism-related
pancytopenia. (leaving a remnant)
17. Wiskott-Aldrich syndrome
A X-linked recessive disease
characterized by
eczema, thrombocytopenia
(20,000 – 40,000) immune
deficiency, and bloody diarrhea
(secondary to the thrombocytopenia).
Splenectomy normalizes the shape, size
and function of platelets. (Increased survival).
18. Sarcoidosis
Granulomatous
disease of unknown
origin.
Splenectomy for hypersplenism-
related pancytopenia.
20. Hereditary spherocytosis
Hemolytic anemia, the
deficiency of
membrane proteins
(spectrin, ankyrin and
protein 4-2)
Characterized by
sphere-shaped
red blood cells.
22. Hereditary nonspherocytic
hemolytic anemia.
• Anaerobic
metabolism
(energy).
• Production of
antioxidants
(glutathione)
Splenectomy is not curative but
improve some conditions.