1. ANTIFUNGALS
Fungus-------single cell organism with cell wall has chitin, no
chlorophyhll.
reproduction by spores. study is mycology
most are resistant to antibacterial drugs.
Infection occurs when immune system is compromised.
microorganisms such as yeasts and molds, mushrooms
MOA: Antifungals work by exploiting differences between
mammalian and fungal cells to kill the fungal organism with fewer
adverse effects to the host. Unlike bacteria, both fungi and
humans are eukaryotes. Thus, fungal and human cells are similar
at the biological level. This makes it more difficult to discover
drugs that target fungi without affecting human cells. As a
consequence, many antifungal drugs cause side effects. Some of
these side effects can be life-threatening if the drugs are not used
properly.
2. ANTIFUNGALS-polyene
• attack cell membrane, similar structure
nystatin used mostly topical.
amphotericin used intravenous unless fungus inside GI.
reactions---fever, chills, rigor, nausea,vomiting, myalgias,
arthralgias, and headache during intravenous infusions.
renal damage
3. ANTIFUNGALS-azoles
• interferes with enzyme for ergosterol
formation yields death.
• used for ringworm, candidiasis
• clotrimazole, miconazole,
ketoconazole,fluconazole
• side effects--naseau, diarrhea, rashes,
liver issues
4. ANTIFUNGALS--griseofulvin
• from Penicillium griseofulvum
• attacks dermatophytes by disrupting mitotic
spindle formation-a critical step in cellular
division.
• for severe skin,hair, nails condition.
• not topical use
• oral use 2 to 4 weeks for skin infections, 4 to
6 weeks for hair and scalp infections, 4 to 8
weeks for foot infections, 3 to 4 months for
fingernail infections, and at least 6 months for
toenail infections.
5. ANTIVIRALS
• Viruses have no cell wall and made up of
nucleic acid components
• Viruses are obligate intracellular parasite
• They do not have a metabolic machinery of
their own – uses host enzymes
• virus can be attacked somewhere along its
reproduction pathway.
6. ANTIVIRALS
• most replication when symptoms appear or
before
• viral replication
• 1--penetrates cell
• 2--synthesis of early protein
• 3--synthesis of RNA or DNA
• 4--synthesis of late protein
• 5--particle assembly and release=cell death
7. ANTIVIRALS
• gamma globulin injection--blood protein with
antibodies hopefully act against virus antigen
to not allow entry into cell.
• to reduce infection of measles, rabies, others
• amantadine--(CDC sometimes disapproves)
prevents uncoating of virus
• for influenza A, rubella.
• maybe useful for chronic fatigue
• side effects---slurred speech, dizziness
8. ANTIVIRALS
• stopping intracelluar synthesis
• ribavarin---inhibits replication of DNA and
RNA virus
• for hepatitus C, respiratory infections,
hemmoraghic fever
• acyclovir--metabolized into a form that
replaces a nucleotide=no more dna
• for herpes simplex and zoster
