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X-RAIS
THE THIRD EYE
Federico, Comotto | Data Scientist at Laife Reply
f.comotto@reply.it
Innovation for Healthcare
LAIFE is the REPLY data company that combines the vertical
expertise on HEALTHCARE & PHARMA with the technological
specialization on AI, ML & BIG DATA.
Medical Imaging, Radiomics, Natural Language Processing,
Analysis of anatomical pathology reports, ChatBot, Behavior
monitoring applications, Digital therapies are some of the use
cases on which LAIFE works on with the largest public and
private hospitals and the Pharma companies.
#AI #ML #BIGDATA #DIGITALTHERAPEUTICS #RADIOMICS
#ONCOLOGY #WELFARE #WELLBEING #CHATBOT #NLP
For more information: info.laife@reply.it
AGENDA
1 Context
2 What is X-RAIS
3 ALFABETO
4 Conclusions
CONTEXT
mammograms are performed
in U.S. yearly
PAIN POINTS
40M of malignant tumors in
mammograms are detected87% women suffer from breast
cancer each year2.1M
WHAT IS X-RAIS
X-RAIS is a medical platform (CE marking – IIa category in progress) based
on Deep Learning, which can be specialized in different modalities and
anatomical districts.
Medical* AI Platform Layer
Imaging Techniques Layer (XR, CAT, MRI, ...)
* Medical certification in progress
AI TO SUPPORT MEDICAL DECISIONS
OUR JOURNEY
Jan 2018 Mar 2018 2019 April 2020 …
X-RAIS was born with a
prototype for analyzing
medical images
Sealed partnership with
ICS Maugeri in
mammography area
Sealed partnership with
Treviso Hospital to
detect suspicious lesions
in mammograms
ALFABETO was born to
support Covid-19
pandemic
9
MAMMOGRAMS
SPECIALIZATION
Anomaly 1
Shape: irregular
Margin: spiculated
X-RAIS
Deep
Learning
10 Partners
involved
Annotated by 25+
radiologist
SOME NUMBERS
10 Server
50000 Iterations
X-RAIS
20180 Images
19865 Anomalies
5350 Cases
FOR MORE INFORMATION
ALFABETO
ALL
FASTER
BETTER
TOGETHER
X-RAIS SUPPORTING DIAGNOSIS DURING
EPIDEMIOLOGICAL EMERGENCY
X-RAIS
THE EXCELLENCE FOR A BETTER HEALTHCARE
WHAT: ALFABETO is a platform based on AI which aims to reduce
hospitalizations by supporting and speeding up diagnosis of Covid-
19.
DECISIONS ARE TAKEN AT HOME
1. Symptomatic patient
asks for assistance
2. Medical visit at patient’s home
(with the support of ALFABETO)
5. Reporting phase
(with ALFABETO)
4. Severity assessment and
progression estimate
3. Patient subjected to tests
6. Hospitalization vs Home stay
AI WORKFLOW: HOW ALFABETO WORKS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
AI WORKFLOW: HOW ALFABETO WORKS
X-RAIS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
Features
extractor
AI WORKFLOW: HOW ALFABETO WORKS
X-RAIS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
Features
extractor
Classifier
AI WORKFLOW: HOW ALFABETO WORKS
X-RAIS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
Features
extractor
Classifier
Doctor takes
the last
decision
AI WORKFLOW: HOW ALFABETO WORKS
X-RAIS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
1. Consolidation
2. Infiltration
3. Edema
4. Effusion
5. Pneumonia
6. Lung Opacity
DenseNet
Approved by
a radiologist
Classifier
Features
extractor
AI WORKFLOW: HOW ALFABETO WORKS
X-RAIS
Machine
Learning
Features
extraction
Vector
CXR
Clinical data
+
Machine
Learning
Classification
Home
Hospital
Input Model
1. Cloud-based
2. Trained more than 50 models using AutoML
3. Cross validated
• Ensemble model
• 0,81 AUC
Classifier
ADVANTAGES
TA K I N G C A R E O F
P AT I E N T S AT H O M E
C L I N I C A L R I S K
R E D U C T I O N
M O R E P R E C I S E A N D
F A S T E R T R E A T M E N T
S T R A T E G Y D E F I N I T I O N
R E D U C E D A C C E S S T O
H O S P I TA L S
I N F O R M AT I O N S H A R I N G A M O N G
H E A LT H C A R E P R O F E S S I O N A L S
A N D P AT I E N T S
D Y N A M I C T R I A G E
CONCLUSIONS
An AI solution using Deep
Learning to analyze
medical images and
support doctors in their
everyday job
X-RAIS
1
Inherently allows the
inclusion of heterogeneous
data to perform predictive
analyses
2
Improves medical
screening and reduce
diagnosis time which
means higher quality in
medical treatments and
reduction in clinical risk
3
LET'S AI SPEAK OUT
• Artificial Intelligence is
mature
• Big Data & AI make
Healthcare industry a
better place
• In Laife Reply, we
develop innovative
solutions based on AI and
Big Data, e.g. X-RAIS and
ALFABETO
“disease costs more
than health”
THANK YOU
info.laife@reply.it
Feedback
Your feedback is important to us.
Don’t forget to rate
and review the sessions.

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X-RAIS: The Third Eye

  • 1. X-RAIS THE THIRD EYE Federico, Comotto | Data Scientist at Laife Reply f.comotto@reply.it
  • 2. Innovation for Healthcare LAIFE is the REPLY data company that combines the vertical expertise on HEALTHCARE & PHARMA with the technological specialization on AI, ML & BIG DATA. Medical Imaging, Radiomics, Natural Language Processing, Analysis of anatomical pathology reports, ChatBot, Behavior monitoring applications, Digital therapies are some of the use cases on which LAIFE works on with the largest public and private hospitals and the Pharma companies. #AI #ML #BIGDATA #DIGITALTHERAPEUTICS #RADIOMICS #ONCOLOGY #WELFARE #WELLBEING #CHATBOT #NLP For more information: info.laife@reply.it
  • 3. AGENDA 1 Context 2 What is X-RAIS 3 ALFABETO 4 Conclusions
  • 5. mammograms are performed in U.S. yearly PAIN POINTS 40M of malignant tumors in mammograms are detected87% women suffer from breast cancer each year2.1M
  • 7. X-RAIS is a medical platform (CE marking – IIa category in progress) based on Deep Learning, which can be specialized in different modalities and anatomical districts. Medical* AI Platform Layer Imaging Techniques Layer (XR, CAT, MRI, ...) * Medical certification in progress AI TO SUPPORT MEDICAL DECISIONS
  • 8. OUR JOURNEY Jan 2018 Mar 2018 2019 April 2020 … X-RAIS was born with a prototype for analyzing medical images Sealed partnership with ICS Maugeri in mammography area Sealed partnership with Treviso Hospital to detect suspicious lesions in mammograms ALFABETO was born to support Covid-19 pandemic
  • 10. 10 Partners involved Annotated by 25+ radiologist SOME NUMBERS 10 Server 50000 Iterations X-RAIS 20180 Images 19865 Anomalies 5350 Cases
  • 13. ALL FASTER BETTER TOGETHER X-RAIS SUPPORTING DIAGNOSIS DURING EPIDEMIOLOGICAL EMERGENCY X-RAIS
  • 14. THE EXCELLENCE FOR A BETTER HEALTHCARE WHAT: ALFABETO is a platform based on AI which aims to reduce hospitalizations by supporting and speeding up diagnosis of Covid- 19.
  • 15. DECISIONS ARE TAKEN AT HOME 1. Symptomatic patient asks for assistance 2. Medical visit at patient’s home (with the support of ALFABETO) 5. Reporting phase (with ALFABETO) 4. Severity assessment and progression estimate 3. Patient subjected to tests 6. Hospitalization vs Home stay
  • 16. AI WORKFLOW: HOW ALFABETO WORKS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model
  • 17. AI WORKFLOW: HOW ALFABETO WORKS X-RAIS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model Features extractor
  • 18. AI WORKFLOW: HOW ALFABETO WORKS X-RAIS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model Features extractor Classifier
  • 19. AI WORKFLOW: HOW ALFABETO WORKS X-RAIS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model Features extractor Classifier Doctor takes the last decision
  • 20. AI WORKFLOW: HOW ALFABETO WORKS X-RAIS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model 1. Consolidation 2. Infiltration 3. Edema 4. Effusion 5. Pneumonia 6. Lung Opacity DenseNet Approved by a radiologist Classifier Features extractor
  • 21. AI WORKFLOW: HOW ALFABETO WORKS X-RAIS Machine Learning Features extraction Vector CXR Clinical data + Machine Learning Classification Home Hospital Input Model 1. Cloud-based 2. Trained more than 50 models using AutoML 3. Cross validated • Ensemble model • 0,81 AUC Classifier
  • 22. ADVANTAGES TA K I N G C A R E O F P AT I E N T S AT H O M E C L I N I C A L R I S K R E D U C T I O N M O R E P R E C I S E A N D F A S T E R T R E A T M E N T S T R A T E G Y D E F I N I T I O N R E D U C E D A C C E S S T O H O S P I TA L S I N F O R M AT I O N S H A R I N G A M O N G H E A LT H C A R E P R O F E S S I O N A L S A N D P AT I E N T S D Y N A M I C T R I A G E
  • 24. An AI solution using Deep Learning to analyze medical images and support doctors in their everyday job X-RAIS 1 Inherently allows the inclusion of heterogeneous data to perform predictive analyses 2 Improves medical screening and reduce diagnosis time which means higher quality in medical treatments and reduction in clinical risk 3
  • 25. LET'S AI SPEAK OUT • Artificial Intelligence is mature • Big Data & AI make Healthcare industry a better place • In Laife Reply, we develop innovative solutions based on AI and Big Data, e.g. X-RAIS and ALFABETO “disease costs more than health”
  • 27. Feedback Your feedback is important to us. Don’t forget to rate and review the sessions.