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a b and z dna

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molecular biology

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a b and z dna

  1. 1. DNA “THE BLUEPRINT OF LIFE” SUJITA MISHRA PI/289 1
  2. 2.  Contents History of DNA Genetic material of cells DNA double helix DNA replication ABZs of DNA 2
  3. 3.  3
  4. 4.  DNA (Deoxyribonucleic Acid) 4
  5. 5.  A History Of DNA  R.FRANKLIN X-ray photo of DNA.  (1952)  Watson & CrickDescribed the DNA from Franklin’s x- ray.  (1953) 5
  6. 6.   GENESUnits of genetic material that codes for a specific trait.  DNA is made up of repeating molecules called as Nucleotides. Genetic Material Of Cells What IS A NUCLEOTIDE ? 6
  7. 7.  DNA Nucleotide 7
  8. 8.  DNA Double Helix 8
  9. 9.  Nitrogenous Base PURINES • Adenine(A) • Guanine(G) PYRIMIDINES • Thymine(T) • Cytosine(C) A or G T or C 9
  10. 10.  DNA Replication 10
  11. 11.  THE ABZs OF DNA Major forms Of DNA A-DNA  Right handed,short & broad,11bp per turn. B-DNA Right handed,longer,thinner,10 bp per turn. Z-DNA Left handed,longest,thinnest,12 bp per turn. 11
  12. 12.  THE ABZs OF DNA 12
  13. 13.   Observed in active site of DNA polymerase  Gram+ bacteria undergoing sporulation.  Deep major groove & shallow minor groove.  Observed under dehydrating conditions.  B-DNAA-DNA (Reversible). A-DNA 13
  14. 14.   Most common DNA.  Each base pair has same width.  Minor groove is narrow & major groove is wide. B-DNA 14
  15. 15.   Seen in conditions of high salt concentration.  Deep minor groove.  No discernible major groove. Z-DNA 15
  16. 16.  16
  17. 17.  17

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