Single page apps like those built with AngularJS can cause accessibility issues if not developed correctly. Dynamic page content and lack of focus management can disorient users. The document provides examples of how to address these challenges, such as programmatically setting page titles, binding clicks to native controls, managing focus with JavaScript, hiding non-essential content for screen readers with ARIA, and using ARIA attributes to provide status updates. Semantic HTML, proper use of tabindex, and fallback navigation are also recommended for building accessible single page apps.