Complications+of+Diabetes

What is Diabetes Mellitus? ,[object Object],[object Object],[object Object],[object Object]

Diagnostic Criteria American Diabetes Association. Diabetes Care. 2004;27(suppl 1):S5-S10 FPG 2-h PPG (OGTT) 126 60 80 100 120 140 160 180 200 Plasma glucose (mg/dL) Normal Diabetes Mellitus 240 220 Diabetes Mellitus Normal IGT IGT 8

Etiological Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],American Diabetes Association

Type- I Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object]

Type- II Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object]

Gestational Diabetes Mellitus (GDM) ,[object Object],[object Object],[object Object]

Salient Clinical Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diabetes Mellitus - Complications

Complications of diabetes mellitus ,[object Object],Chronic (Angiopathy) Macro Vascular Complications Micro Vascular Complications

Risk factors and complications Microvascular disease Eyes Kidneys Nerves Macrovascular disease Ischaemic heart disease Strokes Peripheral vascular disease Feet Hypertension Hyperglycaemia Dyslipidaemia Coagulopathy Smoking

Acute Complications ,[object Object],[object Object],[object Object]

[object Object],Biology of Macrovascular Injury Heart Brain Extremities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],Biology of Microvascular Injury ,[object Object],[object Object],[object Object],Kidney Nerves Retinopathy - Cataract - Glaucoma ,[object Object],[object Object],[object Object],Blindness Kidney failure Amputation Death and/or disability Eye

Microvascular Complications of Diabetes-1 ,[object Object],Normal -------------  Small hemorrhages ---------  Large hemorrhage

[object Object],[object Object],[object Object],[object Object],[object Object],Microvascular Complications of Diabetes-2

Microvascular Complications of Diabetes-3 ,[object Object],[object Object],[object Object]

Mechanism of Complications of Diabetes

Mechanisms causing diabetic complications-1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Consequences of high Sorbitol concentration ,[object Object],[object Object],[object Object],[object Object]

Mechanisms causing diabetic complications-2 ,[object Object],[object Object],[object Object]

Pathological Consequences of Glycation of Proteins in Diabetics ,[object Object],[object Object],[object Object]

Diabetes is Managed, But it Does Not Go Away . ,[object Object],To maintain target blood glucose

Management Of Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Management Of DM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Complications+of+Diabetes

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