To study the usefulness of direct fetal intravenous immunoglobulin (IVIG) infusion along with intrauterine transfusion (IUT) in the management of severe fetal anemia in rhesus (Rh) alloimmunized pregnancies.

1. Direct fetal intravenous immunoglobulin infusion as an adjunct to intrauterine fetal blood transfusion in
rhesus-allommunized pregnancies: a pilot study.
To study the usefulness ofdirectfetal intravenous immunoglobulin (IVIG) infusion along with intrauterine
transfusion (IUT) in the managementofsevere fetal anemia in rhesus (Rh) alloimmunized pregnancies.
Methods
Thirty-four consecutive Rh-isoimmunized pregnantwomen who required serial IUTs received either blood alone
(control group, n = 16) or IVIG and blood (studygroup, n = 18). Pregnancies were followed up to delivery, and
fetal outcome was recorded.The rate of fall of hematocritwas measured and compared between the two groups.
Results
There was a slower rate of fall of hematocritin the study group (IUT and IVIG) compared to the control group
(only IUT). The mean rate of fall was 0.72 ± 0.54% per day in the study group while it was 1.29 ± 0.95% per day
in the control group (p = 0.005).
Conclusions
Fall of fetal hematocritwas reduced in the study group.The results ofthis pilotstudy can be used to time the next
transfusion in patients receiving IVIG along with IUT (taking the rate of fall as 0.70%). This may eventually result
in decreasing the number oftransfusions per fetus..
Authors: Deka D, Sharma KA, Dadhwal V, Singh A, Kumar G, Vanamail P.
Recommended By(co-author):
DR APRAJITA SINGH, MD,DNB,MNAMS
OBSTETRICS & GYNAECOLOGY
Consultant,Director & Founder
Aaditri MultispecialityClinic
R-274,Greater Kailash Part-1,New Delhi 110048 (INDIA)
aaditriclinic@gmail.com +91-11-65658647
Attending Consultant
Indraprastha Apollo Hospitals,New Delhi
https://in.linkedin.com/in/dr-aprajita-singh-md-dnb-mnams-86713749