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Micro-DREZ for Brachial
Neuralgia
Dr Deepak Agrawal
Additional Professor, Neurosurgery
AIIMS
“Pain is a more
terrible lord
of mankind
than even
death itself”
PAIN
Dr. Albert Schweitzer
(1875-1965)
Deafferentation pain
Pain or dysesthesia caused by interruption of the
peripheral or central afferent input in the central
nervous system
Sweet WH. Deafferentation pain in man. Appl Neurophysiol. 1988;51:117–27.
BRACHIAL NEURALGIA
 More than 500 patients/ year at AIIMS
itself
 70% will have brachial Neuralgia
BRACHIAL PLEXUS INJURIES
Microsurgical DREZ-otomy was introduced in 1972
Anatomical studies of the human dorsal root entry zone (DREZ)
showing a topographical segregation of the afferent fibers
according to their size and functional destinations.
MICROSURGICAL DREZ
MICRO DREZ- ANATOMY
MICRO DREZ- ANATOMY
TYPES OF DREZ
DREZ AREA
2 mm deep microsurgical lesion
directed at a 45 degrees angle in
the posterolateral sulcus and
penetrating the dorsal root entry
zone in its ventrolateral aspect, at
the level of all the rootlets
considered involved in spasticity
(and pain)
MICRO DREZ
It destroys mainly the lateral
(nociceptive) and central (myotatic)
afferent fibers as well as the
facilitatory medial part of the
Lissauer tract, while sparing most
of the medial (lemniscal) fibers, the
suppressor lateral part of the
Lissauer tract, and more or less of
the dorsal horn (DH).
EXPOSURE
DREZ SURGERY
POSTOP
• Excess of spasticity, especially when associated with severe pain (Seen in
post-Stroke patients in in Multiple Sclerosis)
• Well-localized cancer pain, such as Pancoast syndrome
• Neuropathic pain due to: brachial plexus injuries; cauda equina and/or
spinal cord lesions (especially for pain corresponding to segmental lesions);
• Peripheral nerve injuries, amputation, herpes
OTHER INDICATIONS
MICROSURGICAL DREZOTOMY
• 44 patients of SCI with severe neuropathic pain
•
Follow-up ranged from 1 to 20 years (mean 6 yrs)
• Immediate pain relief was obtained in 70% of patients and
was long-lasting in 60% of the total series.
• Good long-term results were obtained in 68% of the patients
MICROSURGICAL DREZOTOMY
• Started doing in March 2014
• Total of 8 cases (Including one for Post traumatic severe UL spasticity)
• All have become pain free
• No new deficits/ morbidity/ mortality
AIIMS SERIES
• Is a relatively inexpensive procedure
• Does not require any special equipment
• Should be the preferred treatment in Brachial Neuralgia
• May be also considered for severe spasticity &/or pain in post stroke
patients, SCI patients & pain associated with malignancy
CONCLUSIONS- MICRO DREZ
THANK YOU

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Microscissor DREZ- A new technical modification

  • 1. Micro-DREZ for Brachial Neuralgia Dr Deepak Agrawal Additional Professor, Neurosurgery AIIMS
  • 2. “Pain is a more terrible lord of mankind than even death itself” PAIN Dr. Albert Schweitzer (1875-1965)
  • 3. Deafferentation pain Pain or dysesthesia caused by interruption of the peripheral or central afferent input in the central nervous system Sweet WH. Deafferentation pain in man. Appl Neurophysiol. 1988;51:117–27. BRACHIAL NEURALGIA
  • 4.  More than 500 patients/ year at AIIMS itself  70% will have brachial Neuralgia BRACHIAL PLEXUS INJURIES
  • 5. Microsurgical DREZ-otomy was introduced in 1972 Anatomical studies of the human dorsal root entry zone (DREZ) showing a topographical segregation of the afferent fibers according to their size and functional destinations. MICROSURGICAL DREZ
  • 8.
  • 11. 2 mm deep microsurgical lesion directed at a 45 degrees angle in the posterolateral sulcus and penetrating the dorsal root entry zone in its ventrolateral aspect, at the level of all the rootlets considered involved in spasticity (and pain)
  • 12. MICRO DREZ It destroys mainly the lateral (nociceptive) and central (myotatic) afferent fibers as well as the facilitatory medial part of the Lissauer tract, while sparing most of the medial (lemniscal) fibers, the suppressor lateral part of the Lissauer tract, and more or less of the dorsal horn (DH).
  • 15.
  • 17. • Excess of spasticity, especially when associated with severe pain (Seen in post-Stroke patients in in Multiple Sclerosis) • Well-localized cancer pain, such as Pancoast syndrome • Neuropathic pain due to: brachial plexus injuries; cauda equina and/or spinal cord lesions (especially for pain corresponding to segmental lesions); • Peripheral nerve injuries, amputation, herpes OTHER INDICATIONS
  • 19. • 44 patients of SCI with severe neuropathic pain • Follow-up ranged from 1 to 20 years (mean 6 yrs) • Immediate pain relief was obtained in 70% of patients and was long-lasting in 60% of the total series. • Good long-term results were obtained in 68% of the patients MICROSURGICAL DREZOTOMY
  • 20. • Started doing in March 2014 • Total of 8 cases (Including one for Post traumatic severe UL spasticity) • All have become pain free • No new deficits/ morbidity/ mortality AIIMS SERIES
  • 21. • Is a relatively inexpensive procedure • Does not require any special equipment • Should be the preferred treatment in Brachial Neuralgia • May be also considered for severe spasticity &/or pain in post stroke patients, SCI patients & pain associated with malignancy CONCLUSIONS- MICRO DREZ