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gene hypoxia protein autophagy proteasoma cells chromosomes genome physical loading mitochondria rest potension action potension reception hif heart funny current blood leukocytes coagulation blood physiology erythrocyte lysosome ribosome mrna translation chromatin igf mtor hypertrophy atletic heart smart heart titin streching smc heart sport loading training muscle perception taste buds receptor and signaling cell culture ros anoxia proteins nucleic acid dna epigenetics atpase cell membrane active transport sinaps muscul contraction irisin myokine synaps neuron taste receptors adsorbtion taste cells digestive respiration mirochondria