This document provides an overview of the clinical examination procedures used in endocrinology. It describes the examination of general appearance including facial features, build, skin and nails. It then examines specific areas in more depth including hair, eyes, ears, mouth and various glands and organs. It outlines common endocrine-related abnormalities that may be observed in each area and their potential causes. Key syndromes and disorders are highlighted along with diagrams to illustrate certain clinical findings.
18. Facies With Syndrome
• Hypertelorism,
epicanthic folds, broad
flat nose, low set ears, &
short neck
• Moon face
• Ape like face
• Mongoloid face
• Grotesque face
• Elfin face
• Dull expression face
• Frightened & staring
• Turner & Noonan
syndrome
• Cushing’s syndrome
• Acromegaly
• Down’s syndrome
• Hurler’s syndrome
• William’s syndrome
• Myxedema
• Thyrotoxicosis
19. Build & Stature
• Indices of build & stature
– Height(Herpenden’s stadiometer), lower & upper
segment
– Arm span
– Body mass index
– Waist circumference
20. Causes Of Tall Stature
• Constitutional
• Pituitary giant
With equal
upper & lower
segment
• Marfan syndrome
• Homocystinuria
• Klinefelter’s syndrome
With upper &
lower
segment ratio
≤0.8
26. Neck Examination
• Thyromegaly
• Short neck
(Ratio of height to the distance between
external occipital protuberance & C7
spinous process ≥ 13.6)
– Klippel-Feil syndrome
– Morquio’s syndrome
• Webbed neck
– Noonan syndrome
– Turner syndrome
– Edward syndrome(trisomy
18)
• Low hair line
– Noonan syndrome
– Turner syndrome
– Klippel-Feil syndrome
– Cornelia de Lange’s
syndrome
(Posterior hair line extends below the
level of C5 spinous process or ratio
of distance from external occipital
protuberance from the hair line &
the distance from the hair line to C7
spinous process is >1/6 in male &
>1/4 in female)
30. Cutaneous Manifestation Of Diabetes
• Infections
– Candidal
• Candidal intertrigo,
paronychia, vulvovaginitis,
balanoposthitis
– Pyoderms
• Staphylococcal (recurrent
furuncles & curbuncles)
• Dermopathy
– Most common
– Small, dull red papules with a
superficial scales; slowly resolve
to leave small, brown, depressed
scars
• Acanthosis nigricans
– Velvety hyperpigmented
plaques with a feathered edge
• Necrobiosis lipoidica
– Single or multiple,
asymptomatic, indurated
annular, yellowish brown
plaques. Center is atrophic
with ectatic blood vessels
visible through the thinned
skin
• Granuloma annulare
– Erythematous dermal papules
arranged in an annular pattern
seen on pressure points
32. Cutaneous Manifestations Of Thyroid
Disorders
Hyperthyroidism
• Worm , moist, smooth skin,
best made out on palms &
soles. Palmo-plantar
hyperhydrosis
• Persistent flush of face &
palm
• May be associated with
hyperpigmentation of face or
with vitiligo
• Pre-tibial myxedema
– Asymmetric firm plaques with
a “Peau d’ orange” appearance
Hypothyroidism
• Ichthyotic skin
– Resembles ichthyosis vulgaris
• Dry, cold, pale skin
• Podgy non-pitting
generalized edema
(myxedema)
• Dry, coarse, brittle hair.
Follicular keratoses.
Alopecia of scalp. Supra-ciliary
madarosis of lateral
third of eye brow
37. Cutaneous Manifestations Of
Metabolic Diseases(Porphyrias)
Erythropoietic porphyria
• Congenital erythropoietic
porphyria
– Severe photosensitivity soon
after birth, sun induced blister
– Lesion heal with scar &
mutilating, hypertrichosis
conspicuous on face
– Brown teeth, fluorescence in
Wood’s lamp
– Passing of red colored urine
• Erythropoietic protoporphyria
– Burning, edema, urticaria on
sun exposure
– Thickening of skin & superficial
scarring
– Urine color normal
Hepatic porphyria
• Porphyria cutanea tarda
– Blisters on photo exposed
parts
– Over time, skin becomes
thickened(sclerodermoid) &
scarred
– Hypertrichosis
– Urine is pink & bright coral
pink on Wood’s lamp
• Variegate porphyria
– Like previous
– Precipitated by drugs
– Abdominal pain, neuro-psychiatric
symptom
– Red colored urine during
attack of abdominal pain
38. Cutaneous Manifestations Of
Metabolic Diseases(Xanthoma)
Type Morphology Sites Associated
hyperlipidemia
Xanthelesma
palpebrarum
Soft, yellow, flat,
ovoid plaques
Eyelids Type 2,3
Secondary
Tuberous
xanthoma
Firm, yellow nodule Elbows, knees,
back
Type 2,3
Secondary
Tendinous
xanthoma
Subcutaneous
swelling along
tendons
Fingers & Achilles
tendon
Type 2,3
Secondary
Eruptive xanthoma Shower of small,
multiple, yellow
papules
Buttocks &
shoulders
Type 1, 2, 4
Secondary
Plane xanthomas Yellow macules Palmer creases Type 3
Secondary
40. Extremities (Digits)
• Arachnodactyly
– Unduly long & thin fingers &
toes with positive wrist &
thumb signs(Marfan
syndrome, sickle cell
anaemia)
• Polydactyly
– Presence of extra fingers or
toes (Laurence-Moon-Biedl
syndrome)
• Syndactyly
– Webbed finger, fusion
between the adjacent fingers
or toes may be dermal or
osseous(Laurence-Moon-
Biedl syndrome)
• Clindactyly
– Incurved fingers, mainly seen
in little finger with increased
space between 4th & 5th
finger(Down’s syndrome)
• Fingerized thumb
– Triphalangeal thumb(Holt-
Oram syndrome)
• Brachydactyly
– Equal length, all fingers sre
shortened(Down, Turner,
Hyperparathyroidism)
• Clenched hand
– Index finger overlapping over
3rd & 5th finger overlapping
over 4th (Edward syndrome)
41. Extremities(Nail)
• Acropachy( Grave’s
dermopathy +
clubbing)
• Plummer nails
• Square/broad nails
• Thyrotoxicosis
• Hyperthyroidism
• Acromegaly
42. Extremities(Feet)
• Pes cavus(claw foot)
– Exaggeration of the
longitudinal arch of the
foot resulting in a
marked upward
convexity of the instep
& drawing up of toes
• Rocker bottom foot
– Due to protruding heel
– Edward syndrome
• Genu varum
– Outward bowing of legs
with knees wide apert
– Achondroplasia,
Osteogenesis
imperfecta
• Genu valgum
– Inward bowing of legs
– Laurence-Moon-Biedl
– Rickets
46. Depth-Ischemia Classification
Depth
classification
Definition
0 At risk foot
No ulceration
1 Superficial
ulceration, not
infected
2 Deep ulceration
Exposing tendons
or joint
3 Extensive
ulceration or
abscess
Ischaemia
classification
Definition
A No ischaemia
B Ischaemia without
gangrene
C Partial (fore foot)
gangrene
D Complete foot
gangrene
47. Extremities(Diabetic Feet)
Neuro-arthropathy
• Classified according to
Sanders & Mrddjencovich
– Pattern 1 – Forefoot
– Pattern 2- Lisfranc’s joint
– Pattern 3 – lesser tarsus
– Pattern 4 – ankle
– Pattern 5 – calcaneus or
posterior piller
Peripheral arterial disease
• Four time more prevalent
in diabetics
• Augmented by smoking
• Arterial occlusion typically
involve infra-popliteal
artery but spares the
dorsalis pedis
50. Inspection (Thyroid)
• Movement with deglutition
• Movement with protrusion
of tongue
• Position & extent of
swelling of both lobes &
isthmus
• Shape, size, surface,
margin, skin over swelling
• Any visible pulsation
• Any venous prominence
over neck or chest wall
• Inspection for toxicity
– Tremor of hand & tongue
– Exophthalmos
– Dalrymple’s sign
– Von Graefe’s sign
– Joffroy’s sign
– Moebius’s sign
– Stellwag’s sign
– Pemberton’s sign
51. Inspection
Inspection of breast
• Degree of enlargement of
male breast in
gynaecomastia
• Female breast may be
atrophied in virilization
• Tanner staging
Inspection of external genitalia
• Male
– Penile length
– Scrotal apperance
– Pubic hair
– Tanner staging of pubic hair
• Female
– Clitoromegaly
– Pubic hair & Tanner staging
52. Palpation(Thyroid)
• Temperature
• Tenderness
• Movement with
deglutition
• Position & extent of
swelling
• Shape, size, surface,
margin
• Consistency
• Neck circumference
• Pulsation
• Thrill
• Skin fixity
• Mobility
• Position of larynx &
trachea
• Carotid pulsation
Different methods of
palpation of thyroid are –
Lahey’s, Pizzilo’s, Crile’s
method
53. Palpation
Palpation of breast
• Enlargement of male
breast & its degree of
enlargement with relation
to disc
• Any nodule, lump
Palpation of external genitalia
• Stretched penile length
• Approximate volume of
testes & consistency
• Palpation of labial fold to
see the presence of gonads
54. Percussion & Auscultation
• Percussion over manubrium sterni for
evaluation of retro-sternal prolongation
thyroid swelling
• Any bruit over thyroid audible or not
55. Measurement
• Upper segment – from vortex to upper border of
symphysis pubis
• Lower segment – from upper border of
symphysis pubis to heel
• Body mass index – (weight in Kg)/height(m2)
• Waist circumferance – measured at a point
between lowest point of costal margin & heighst
point of ileal crest
• Waist:Hip ratio
56. Sexual Maturation Index
• Breast – Tanner staging (stage 1 to stage 5)
• Pubic hair – Tanner staging (stage 1 to stage
6)
• Stretched penile length –
• Testicular volume – Prader’s orchidometer
• Clitoral index – length x breath of clitoris