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ABNORMAL UTERINE BLEEDING
drsujnanendra@gmail.com
PALM COEIN CLASSIFICATION
AUB-P: Polyp (Uterine or Cervical Polyps)
AUB-A: Adenomyosis
AUB-L: Leiomyoma
AUB-M:
Malignancy/hyperplasia
• Cervical Intraepithelial Neoplasia, Cervical Cancer
• Endometrial Hyperplasia and Uterine Cancers
• Oestrogen-secreting (granulosa cell) ovarian tumours
AUB-C:
Coagulopathy
• Von Willebrand Disease
• Coagulation Factor Deficiencies, e.g., Hypofibrinogenemia,
Haemophilia A and B carriers, Thrombocytopenia
AUB-O:
Ovulation dysfunction
• Hepatic Failure (AUB is present in 60% of these patients):
• AUB is caused by ovulation dysfunction (abnormal oestrogen
metabolism), coagulation factor deficiency (secondary to diminished
synthesis), and thrombocytopenia (secondary to portal
hypertension)
• Chronic Renal Failure (80% of patients requiring dialysis): ovulatory
dysfunction is due to disturbance of pulsatile GnRH secretion
Endocrinopathies, e.g., hypothyroidism, adrenal disorders, polycystic
ovary syndrome, hyperprolactinemia, obesity,
AUB-E:
Endometrial
dysfunction
• Atrophic endometritis, e.g., postmenopausal
AUB-I:
Iatrogenic
• Exogenous hormones, e.g., hormonal contraceptives, steroids
• Intrauterine devices
AUB-N:
Not otherwise specified
• Müllerian anomalies, e.g., didelphys, septate and bicornuate uterus
• Arteriovenous malformation (congenital or acquired)
• Cesarean scar defect

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PALM-COEIN Classification of AUB (Abnormal Uterine Bleeding)

  • 1. ABNORMAL UTERINE BLEEDING drsujnanendra@gmail.com PALM COEIN CLASSIFICATION AUB-P: Polyp (Uterine or Cervical Polyps) AUB-A: Adenomyosis AUB-L: Leiomyoma AUB-M: Malignancy/hyperplasia • Cervical Intraepithelial Neoplasia, Cervical Cancer • Endometrial Hyperplasia and Uterine Cancers • Oestrogen-secreting (granulosa cell) ovarian tumours AUB-C: Coagulopathy • Von Willebrand Disease • Coagulation Factor Deficiencies, e.g., Hypofibrinogenemia, Haemophilia A and B carriers, Thrombocytopenia AUB-O: Ovulation dysfunction • Hepatic Failure (AUB is present in 60% of these patients): • AUB is caused by ovulation dysfunction (abnormal oestrogen metabolism), coagulation factor deficiency (secondary to diminished synthesis), and thrombocytopenia (secondary to portal hypertension) • Chronic Renal Failure (80% of patients requiring dialysis): ovulatory dysfunction is due to disturbance of pulsatile GnRH secretion Endocrinopathies, e.g., hypothyroidism, adrenal disorders, polycystic ovary syndrome, hyperprolactinemia, obesity, AUB-E: Endometrial dysfunction • Atrophic endometritis, e.g., postmenopausal AUB-I: Iatrogenic • Exogenous hormones, e.g., hormonal contraceptives, steroids • Intrauterine devices AUB-N: Not otherwise specified • Müllerian anomalies, e.g., didelphys, septate and bicornuate uterus • Arteriovenous malformation (congenital or acquired) • Cesarean scar defect