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Biochemistry of saliva ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Clinical Highlights ,[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Saliva Definition :  Secretions of  salivary  glands  (parotid and submandibular/sublingual) Composition of Saliva :   4 major components 1-mucus that serves as a lubricant.  2-amylase ->initiates the digestion of starch.  3-lingual lipase -> begins digestion of fat.  4-electrolyte solution (Na+,Cl -  , K+, HCO3 -  ->  moistens food. 5-proteins& enzymes: Statherins, Proline-rich Proteins (PRPs), Histatins, Cystatins, Lysozyme, Salivary peroxidase  Dr/ Ragaa Salama
[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
functions of saliva Dr/ Ragaa Salama Salivary Families Anti- Bacterial Buffering Digestion Mineral- ization Lubricat- ion &Visco- elasticity Tissue Coating Anti- Fungal Anti- Viral Carbonic anhydrases, Histatins Amylases, Mucins, Lipase Cystatins, Histatins, Proline- rich proteins, Statherins Mucins, Statherins Amylases, Cystatins, Mucins,  Proline-rich proteins, Statherins Histatins Cystatins, Mucins Amylases, Cystatins, Histatins, Mucins, Peroxidases
Mucin Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Amylases ,[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Lingual Lipase ,[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Statherins ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Proline-rich Proteins (PRPs) ,[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Histatins ,[object Object],[object Object],Dr/ Ragaa Salama Cystatins ,[object Object],[object Object],[object Object],[object Object]
Lysozyme  (  LZ ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Salivary peroxidase systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Regulation of oral microorganisms by SP/MP Dr/ Ragaa Salama Food Ingestion carbohydrates Stimulation Metabolism H + Recovery O 2 thiols Inhibition Salivary Glands SCN -  + H 2 O 2 OSCN - /HOSCN Autoinhibition spontaneous +SP Unstimulated bacteria Inhibited bacteria Active bacteria
Other anti-microbial activities of LZ ,[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama
Anti-microbial activities of saliva Dr/ Ragaa Salama
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr/ Ragaa Salama

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Composition Of Saliva 2010

  • 1.
  • 2.
  • 3. Saliva Definition : Secretions of salivary glands (parotid and submandibular/sublingual) Composition of Saliva : 4 major components 1-mucus that serves as a lubricant. 2-amylase ->initiates the digestion of starch. 3-lingual lipase -> begins digestion of fat. 4-electrolyte solution (Na+,Cl - , K+, HCO3 - -> moistens food. 5-proteins& enzymes: Statherins, Proline-rich Proteins (PRPs), Histatins, Cystatins, Lysozyme, Salivary peroxidase Dr/ Ragaa Salama
  • 4.
  • 5. functions of saliva Dr/ Ragaa Salama Salivary Families Anti- Bacterial Buffering Digestion Mineral- ization Lubricat- ion &Visco- elasticity Tissue Coating Anti- Fungal Anti- Viral Carbonic anhydrases, Histatins Amylases, Mucins, Lipase Cystatins, Histatins, Proline- rich proteins, Statherins Mucins, Statherins Amylases, Cystatins, Mucins, Proline-rich proteins, Statherins Histatins Cystatins, Mucins Amylases, Cystatins, Histatins, Mucins, Peroxidases
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14. Regulation of oral microorganisms by SP/MP Dr/ Ragaa Salama Food Ingestion carbohydrates Stimulation Metabolism H + Recovery O 2 thiols Inhibition Salivary Glands SCN - + H 2 O 2 OSCN - /HOSCN Autoinhibition spontaneous +SP Unstimulated bacteria Inhibited bacteria Active bacteria
  • 15.
  • 16. Anti-microbial activities of saliva Dr/ Ragaa Salama
  • 17.