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Endoscopy Conclave
One Day Live Endoscopic Workshop & CME
01.09.2013
Sunday, 8am-6pm
AC Auditorium-Level V
@ Lotus hospital, Erode
Hosted by
IMA TN SB- AMS Wing
IMA Erode Branch
ASI Erode City Chapter
Delegates: Rs:1000/- Postgraduates: Rs: 500/-
Morning Session: ( 8am-1`pm)
•Live Endoscopy workshop: Basic
Diagnostic/ Banding of Varices/Sclerotherapy
Dilatation of Stricture esophagus
•10 min Lectures on ‘Endoscopic Practice Guidelines ‘
Endoscopic management of Corrosive stricture: When and How?:
Management of variceal bleeding: Before and after endotherapy:
Role of endoscopy in Upper GI malignancy
FB esophagus:
•Live Endoscopy Workshop: Advanced
Stent deployment/Glue Injection of Fundal varices
Polypectomy
•‘Futuristic’ Lectures:
 Tomorrow’s World of Endoscopy
Why surgeons should always be doing endoscopy?:
Endoscopy in the era of Laparoscopy:
•Endo quiz:
Post Lunch Session(2-4pm)
•Panel Discussion: Team approach in the management of GI disorders:
GERD, Achalasia, Upper GIBleeding , Bile duct stones,
•Live Colonoscopy/ERCP Workshop
Colonoscopic polypectomy
Bile duct stone removal/Stenting
Pancreatic endotherapy
•Challenging situations for endoscopist
Upper GI bleeding with normal endoscopy: How to proceed?:
Difficulty reaching caecum during Ccolonoscopy : Tricks of the Trade:
Post Tea Session( 4-6pm)
•Humour in Gastroenterology
•Convocation and Award Ceremony at 4.30pm
CURRENT MANAGEMENT OF
INCISIONAL HERNIA
Dr.S.Easwaramoorthy
Dr.TC.Gnanasekaran
Dr.KV.Durairaj
ASI Erode City Branch
PROF.JR.SANKARAN SYMPOSIUM
@TN&P ASICON 2013
Symposium on Management of
Incisional hernia.
 Dr.S.Easwaramoorthy 20min
 Pathogenesis of Incisional hernia
 Prevention of incisional hernia
 Evaluation and Current management of incisional hernia
 All, we should know about Mesh for hernia!
 Dr.T.G.Gnanasekaran 15min
 Open mesh repair and abdominoplasty
 Dr.K.V.Durai raj 15min
 Laparoscopic mesh repair of incisional hernia
 Case scenarios and discussion 10min
Incisional Hernia
Why it happens?
Patient factors
Surgeon factors
Disease factors
Patient Factors
 Obesity
 Diabetes
 Renal Failure
 Anaemia and Hypoproteinemia
 Post Operative Chest Infection
Disease Factors
 Peritonitis
 Visceral Cancer/ascites
 Colostomy
Surgeon’s Factors
 Incision
 Low midline/ Subcostal
 Drain/Stoma
 Wound Protection
 SuturingTechnique
Suturing Technique
 Type of Suture material
 Absorbable :Vicryl/PDS/Dexon
 Non absorbable : Nylon/Prolene/Ethibond
 Size of Suture
 Technique of Suturing
Peritoneum?
1 cm across and 1 cm apart
Rule of 4
Clinical Assessment
Lying Standing
Loss of Abdominal Domain
Role of Imaging in Incisional Hernia
CT Abdomen
How to manage Incisional hernia?
 Open procedure (with Abdominoplasty)
 Anatomical Repair
 Component Separation technique
 Mesh repair
 Sublay, Inlay, Onlay
 Laparoscopic repair
 IPOM
How to manage Incisional hernia?
 Open procedure (with Abdominoplasty)
 Anatomical Repair
 Component Separation technique
 Mesh repair
 Laparoscopic repair
 Mesh repair
Why Mesh?
 Low recurrence rate
 Inguinal hernia repair
 Bassini’s repair : 10%
 Shouldice repair : 1%
 Lichtenstein’s Mesh repair : <1%
 Ventral hernia
 SutureVs Mesh: : 50%Vs 10%
 Tension free & Pain free
 Quick recovery
 Quick to learn and easy to do!
Why Mesh?
Pathogenesis of Hernia
 Defective Collagen
 Reduced ratio of type I and type III collagen
 Type I: MatureCollagen, strong and normal tissue
 Type III: ImmatureCollagen, weak, in healing wounds
 Type I :Type III ratio normally is 4:1
 Connective tissue pathology is not only a cause of primary
herniation but its presence can prevent cure!
 Increased matrix metalloproteinase activity(MMP)
‘Understand theWound Biology’
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia?
Raphael Rosch, Uwe Klinge, Zhongyi Si, Karsten Junge, Bernd Klosterhalfen, and
Volker Schumpelick, BMC Med Genet. 2002; 3: 2.
Lichtenstein’s Mesh Repair
Tension Free repair
•Under LA
•Day care
•Low recurrence rate!
Billroth’s Vision
‘‘If we could artificially produce tissues of the density and toughness of
fascia and tendon the secret of the radical cure of hernia would
be discovered’’.
- Beitrage zur Chirurgie (1878)
Inventor of Prosthetic Mesh repair:
Dr. Francis Usher (1908-1980)
• Inventor of Polyehylene(Marlex) and Polypropylene mesh
• Several Animal studies about their inertness
• 20 papers
• Innovative ways of placing the meshes: Inlay,Overlay, Sandwich tech etc
Stoppa’s Mesh Repair
Pre peritoneal Mesh Over Myopectineal Orifice
GPRVS
‘‘In the adult, repairing
inguinal hernias in the inguinal canal and femoral hernias
in the femoral canal is like closing the curtain instead
of shutting the window’’
Mesh repair of Incisional Hernia
 Why Mesh?
 What type of Mesh?
 Where to place the Mesh?
 How to fix the mesh?
 Mesh related complications
Types of Mesh
 Synthetic Mesh
 Non absorbable
 Polyprophylene(Prolene)
 Polyethylene(Marlex)
 Polyester(Dacron)
 PTFE (Teflon/Gordex)
 Absorbable
 Vicryl
 Combined
 Vipro
 Synthetic with Absorbable Barrier( Dual mesh)
 Parietex
 Proceed
 Etc
 Biological Mesh
 Surgisis ( Porcine submucosa)
 Alloderm (Cadaveric human dermis)
What Mesh
Light weight Vs Heavy weight?
Light weight Mesh Heavy weight Mesh
Definition? Light wt, thin fibres,
macro pores (>1.5mm)
Less amt of FB
Heavy wt, thick fibres,
micro pores (< 1.5mm)
So more amount of FB
Qualities Flexible
Less FB reaction and pain
Stiffer
More FB reaction and pain
(Problem of adhesion, fistula)
Shrinks more
Stronger! - so what
Examples Ultrapro,Vipro Marlex, Dacron, PTEF
The lightweight and large porous mesh concept for hernia repair.
Klosterhalfen B, Junge K, Klinge U. Expert Rev Med Devices. 2005 Jan;2(1):103-17.
Laparoscopic Ventral Hernia Repair
Choice of Composite Mesh
Name Parietal side Visceral Side Longevity Remarks By
Parietex Polyester Atelocollagen,
PEG, Glycerol
20 days expensive Covidien
Proceed Polypropylene Oxidised (ORC)
regenerated
cellulose/PDS
30 days Ethicon
Sepramesh PP PGA/Hydrogel 30 days Davol
C QUR PP Omega 3 FA Atrium
ProVISC 160 Polyester Polyurethane Life Cost effective Lotus
Dual Mesh e PTFE (rough) e PTFE(smooth) Life Gore
Kugel/
Composix
PP(HW) e PTFE Life Cann’t trim Bard
Parietex Mesh
Features:
 Polyester with Collagen
cover on the visceral side
 No adhesion or infection
 Handles well during Lap
 Holds sutures well
 Can be trimmed
Moreno-Egea A, Liron R Girela E, Aguayo JL. Laparoscopic repair of ventral and incisional hernias
using a new composite mesh (Parietex): initial experience.
2001 Surg Laparoc Endosc PercutanTech Apr;11(2):103-6
Proceed Mesh (Ethicon)
 Parietal Side
 PP(LW) encapsulaed in PDS
 Blue stripped side
 Visceral Side
 ORC ( Oxidised regenerated
cellulose)
 Macroporous
 Conforms to anatomy
 Can be trimmed
Downside:
 Ensure meticulous hemostasis
or else adhesions likely
 Shrinks by 30%
 Delamination and seroma
Proceed Mesh (Ethicon)
Time line
1 week
2 weeks
Day 1
3 months
Pro VISC 160
 Polyester
 White Parietal side
 Polyurethane
 Blue smooth visceral side
 With Sutures
 Pre cut in various sizes
Parietal side: PP
Visceral side: e PTFE
Bard (Composix) Gore Dual Mesh
Parietal side: Rough PTFE
Visceral side: smooth PTFE
Mesh repair of Incisional Hernia
 Why Mesh?
 What type of Mesh?
 Where to place the Mesh?
 How to fix the mesh?
 Mesh related complications
Where to place the Mesh?
On Lay In Lay
Under Lay IPOM
Pascal’s Hydrostatic Principle
OnlayVs Inlay
Effect of Intra abdominal Pressure
Choose a mesh at least 5cm larger
than the defect all round.
Mesh repair of Incisional Hernia
 Why Mesh?
 What type of Mesh?
 Where to place the Mesh?
 How to fix the mesh?
 Mesh related complications
Mesh Fixation Methods…
AbsorbaTack (Covidien)
Permasorb (Davol / Bard )
Fibrin sealant
SpiralTackers
Staples
Fibrin Glue
Suture
Trans Facial Suture Fixation
Ideal Fixation Method
No Type of Fixation Features
1 Trans Fascial suture
fixation
Chronic pain
2 Suturing 2cm apart
3 SpiralTitatinum
Tackers
2cm apart
Double crown technique
Nerve entrapment, adhesion, rarely tacker hernia
4 Absorbable tackers For initial 1 year
5 Fibrin Glue Suitable for inguinal hernia
?Ventral Hernia: Alternative or Adjunct: needs trial.
Closure of Hernia defect to avoid mesh protrusion or displacement
To with stand the intra abdominal tangential force and also shearing
Force due to abdominal muscle contraction
Mesh repair of Incisional Hernia
 Why Mesh?
 What type of Mesh?
 Where to place the Mesh?
 How to fix the mesh?
 Mesh related complications
Mesh Related Complications…
 Infection
 Surgeon’s nightmare
 Intestinal adhesions
 Composite mesh for laparoscopic ventral hernia repair
 Bowel obstructions
 Erosion of the prosthesis into the adjacent hollow viscus
 Contraction of prosthesis
 At least 5cm larger than the size of the defect
Prevention of Mesh infection
Consider
 Patient factors
 Smoking
 DM
 Obesity
 Re operation
 Big incision
 Type of Mesh
 Macroporous vs microporous
 Impregnated mesh
 Technique
 LapVs Open
 On layVs In lay
 Prophylactic antibiotics
 Avoid unplanned enterotomy
 Infected field
 Absorbable mesh
 Biological mesh
Ventral hernia repair
•Risk of infection is 3-10% in Open mesh repair
•Risk of infection is < 1% in Lap Mesh repair
Conclusion
 Mesh repair of abdominal wall hernia is the
Standard of Care.
 Composite mesh has to be used for ventral hernia
 Avoid Mesh related complications , if possible
Next
 Dr.T.G.Gnanasekaran 15min
 Open mesh repair and abdominoplasty
 Dr.K.V.Durai raj 15min
 Laparoscopic mesh repair of incisional hernia
 Case scenarios and discussion 10min
•21year old lady,
•Para 1
•Large Incisional hernia following c-section
•Yet to complete her family
•SurgeryVs Conservative treatment
•Pregnancy after a mesh repair
•Mesh repair during C-section
Case 1
•40 year old obese lady
•Abdominal hysterectomy 5 years ago
•Incisional Hernia in Lower midline scar
•Has Symptomatic Gall stones
•Open /Laparoscopic/Combined
Case 2
•35 year old lady
•Laparoscopic hysterectomy 6 months ago
•Umbilical Port site Hernia
•Why?
•SutureVs Mesh?
Case 3
Endoscopy Conclave
One Day Live Endoscopic Workshop & CME
01.09.2013
Sunday, 8am-6pm
AC Auditorium-Level V
@ Lotus hospital, Erode
Hosted by
IMA TN SB- AMS Wing
IMA Erode Branch
ASI Erode City Chapter
Delegates: Rs:1000/- Postgraduates: Rs: 500/-
Current management of incisional hernia

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Current management of incisional hernia

  • 1.
  • 2. Endoscopy Conclave One Day Live Endoscopic Workshop & CME 01.09.2013 Sunday, 8am-6pm AC Auditorium-Level V @ Lotus hospital, Erode Hosted by IMA TN SB- AMS Wing IMA Erode Branch ASI Erode City Chapter Delegates: Rs:1000/- Postgraduates: Rs: 500/-
  • 3. Morning Session: ( 8am-1`pm) •Live Endoscopy workshop: Basic Diagnostic/ Banding of Varices/Sclerotherapy Dilatation of Stricture esophagus •10 min Lectures on ‘Endoscopic Practice Guidelines ‘ Endoscopic management of Corrosive stricture: When and How?: Management of variceal bleeding: Before and after endotherapy: Role of endoscopy in Upper GI malignancy FB esophagus: •Live Endoscopy Workshop: Advanced Stent deployment/Glue Injection of Fundal varices Polypectomy •‘Futuristic’ Lectures:  Tomorrow’s World of Endoscopy Why surgeons should always be doing endoscopy?: Endoscopy in the era of Laparoscopy: •Endo quiz: Post Lunch Session(2-4pm) •Panel Discussion: Team approach in the management of GI disorders: GERD, Achalasia, Upper GIBleeding , Bile duct stones, •Live Colonoscopy/ERCP Workshop Colonoscopic polypectomy Bile duct stone removal/Stenting Pancreatic endotherapy •Challenging situations for endoscopist Upper GI bleeding with normal endoscopy: How to proceed?: Difficulty reaching caecum during Ccolonoscopy : Tricks of the Trade: Post Tea Session( 4-6pm) •Humour in Gastroenterology •Convocation and Award Ceremony at 4.30pm
  • 4. CURRENT MANAGEMENT OF INCISIONAL HERNIA Dr.S.Easwaramoorthy Dr.TC.Gnanasekaran Dr.KV.Durairaj ASI Erode City Branch PROF.JR.SANKARAN SYMPOSIUM @TN&P ASICON 2013
  • 5. Symposium on Management of Incisional hernia.  Dr.S.Easwaramoorthy 20min  Pathogenesis of Incisional hernia  Prevention of incisional hernia  Evaluation and Current management of incisional hernia  All, we should know about Mesh for hernia!  Dr.T.G.Gnanasekaran 15min  Open mesh repair and abdominoplasty  Dr.K.V.Durai raj 15min  Laparoscopic mesh repair of incisional hernia  Case scenarios and discussion 10min
  • 6.
  • 7. Incisional Hernia Why it happens? Patient factors Surgeon factors Disease factors
  • 8. Patient Factors  Obesity  Diabetes  Renal Failure  Anaemia and Hypoproteinemia  Post Operative Chest Infection
  • 9. Disease Factors  Peritonitis  Visceral Cancer/ascites  Colostomy
  • 10. Surgeon’s Factors  Incision  Low midline/ Subcostal  Drain/Stoma  Wound Protection  SuturingTechnique
  • 11. Suturing Technique  Type of Suture material  Absorbable :Vicryl/PDS/Dexon  Non absorbable : Nylon/Prolene/Ethibond  Size of Suture  Technique of Suturing
  • 12. Peritoneum? 1 cm across and 1 cm apart Rule of 4
  • 15. Role of Imaging in Incisional Hernia CT Abdomen
  • 16. How to manage Incisional hernia?  Open procedure (with Abdominoplasty)  Anatomical Repair  Component Separation technique  Mesh repair  Sublay, Inlay, Onlay  Laparoscopic repair  IPOM
  • 17.
  • 18. How to manage Incisional hernia?  Open procedure (with Abdominoplasty)  Anatomical Repair  Component Separation technique  Mesh repair  Laparoscopic repair  Mesh repair
  • 19. Why Mesh?  Low recurrence rate  Inguinal hernia repair  Bassini’s repair : 10%  Shouldice repair : 1%  Lichtenstein’s Mesh repair : <1%  Ventral hernia  SutureVs Mesh: : 50%Vs 10%  Tension free & Pain free  Quick recovery  Quick to learn and easy to do!
  • 20. Why Mesh? Pathogenesis of Hernia  Defective Collagen  Reduced ratio of type I and type III collagen  Type I: MatureCollagen, strong and normal tissue  Type III: ImmatureCollagen, weak, in healing wounds  Type I :Type III ratio normally is 4:1  Connective tissue pathology is not only a cause of primary herniation but its presence can prevent cure!  Increased matrix metalloproteinase activity(MMP) ‘Understand theWound Biology’ A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? Raphael Rosch, Uwe Klinge, Zhongyi Si, Karsten Junge, Bernd Klosterhalfen, and Volker Schumpelick, BMC Med Genet. 2002; 3: 2.
  • 21. Lichtenstein’s Mesh Repair Tension Free repair •Under LA •Day care •Low recurrence rate!
  • 22. Billroth’s Vision ‘‘If we could artificially produce tissues of the density and toughness of fascia and tendon the secret of the radical cure of hernia would be discovered’’. - Beitrage zur Chirurgie (1878)
  • 23. Inventor of Prosthetic Mesh repair: Dr. Francis Usher (1908-1980) • Inventor of Polyehylene(Marlex) and Polypropylene mesh • Several Animal studies about their inertness • 20 papers • Innovative ways of placing the meshes: Inlay,Overlay, Sandwich tech etc
  • 24. Stoppa’s Mesh Repair Pre peritoneal Mesh Over Myopectineal Orifice GPRVS ‘‘In the adult, repairing inguinal hernias in the inguinal canal and femoral hernias in the femoral canal is like closing the curtain instead of shutting the window’’
  • 25. Mesh repair of Incisional Hernia  Why Mesh?  What type of Mesh?  Where to place the Mesh?  How to fix the mesh?  Mesh related complications
  • 26. Types of Mesh  Synthetic Mesh  Non absorbable  Polyprophylene(Prolene)  Polyethylene(Marlex)  Polyester(Dacron)  PTFE (Teflon/Gordex)  Absorbable  Vicryl  Combined  Vipro  Synthetic with Absorbable Barrier( Dual mesh)  Parietex  Proceed  Etc  Biological Mesh  Surgisis ( Porcine submucosa)  Alloderm (Cadaveric human dermis)
  • 27. What Mesh Light weight Vs Heavy weight? Light weight Mesh Heavy weight Mesh Definition? Light wt, thin fibres, macro pores (>1.5mm) Less amt of FB Heavy wt, thick fibres, micro pores (< 1.5mm) So more amount of FB Qualities Flexible Less FB reaction and pain Stiffer More FB reaction and pain (Problem of adhesion, fistula) Shrinks more Stronger! - so what Examples Ultrapro,Vipro Marlex, Dacron, PTEF The lightweight and large porous mesh concept for hernia repair. Klosterhalfen B, Junge K, Klinge U. Expert Rev Med Devices. 2005 Jan;2(1):103-17.
  • 28. Laparoscopic Ventral Hernia Repair Choice of Composite Mesh Name Parietal side Visceral Side Longevity Remarks By Parietex Polyester Atelocollagen, PEG, Glycerol 20 days expensive Covidien Proceed Polypropylene Oxidised (ORC) regenerated cellulose/PDS 30 days Ethicon Sepramesh PP PGA/Hydrogel 30 days Davol C QUR PP Omega 3 FA Atrium ProVISC 160 Polyester Polyurethane Life Cost effective Lotus Dual Mesh e PTFE (rough) e PTFE(smooth) Life Gore Kugel/ Composix PP(HW) e PTFE Life Cann’t trim Bard
  • 29. Parietex Mesh Features:  Polyester with Collagen cover on the visceral side  No adhesion or infection  Handles well during Lap  Holds sutures well  Can be trimmed Moreno-Egea A, Liron R Girela E, Aguayo JL. Laparoscopic repair of ventral and incisional hernias using a new composite mesh (Parietex): initial experience. 2001 Surg Laparoc Endosc PercutanTech Apr;11(2):103-6
  • 30. Proceed Mesh (Ethicon)  Parietal Side  PP(LW) encapsulaed in PDS  Blue stripped side  Visceral Side  ORC ( Oxidised regenerated cellulose)  Macroporous  Conforms to anatomy  Can be trimmed Downside:  Ensure meticulous hemostasis or else adhesions likely  Shrinks by 30%  Delamination and seroma
  • 31. Proceed Mesh (Ethicon) Time line 1 week 2 weeks Day 1 3 months
  • 32. Pro VISC 160  Polyester  White Parietal side  Polyurethane  Blue smooth visceral side  With Sutures  Pre cut in various sizes
  • 33. Parietal side: PP Visceral side: e PTFE Bard (Composix) Gore Dual Mesh Parietal side: Rough PTFE Visceral side: smooth PTFE
  • 34. Mesh repair of Incisional Hernia  Why Mesh?  What type of Mesh?  Where to place the Mesh?  How to fix the mesh?  Mesh related complications
  • 35. Where to place the Mesh? On Lay In Lay Under Lay IPOM
  • 36. Pascal’s Hydrostatic Principle OnlayVs Inlay Effect of Intra abdominal Pressure Choose a mesh at least 5cm larger than the defect all round.
  • 37. Mesh repair of Incisional Hernia  Why Mesh?  What type of Mesh?  Where to place the Mesh?  How to fix the mesh?  Mesh related complications
  • 38. Mesh Fixation Methods… AbsorbaTack (Covidien) Permasorb (Davol / Bard ) Fibrin sealant SpiralTackers Staples Fibrin Glue Suture
  • 40. Ideal Fixation Method No Type of Fixation Features 1 Trans Fascial suture fixation Chronic pain 2 Suturing 2cm apart 3 SpiralTitatinum Tackers 2cm apart Double crown technique Nerve entrapment, adhesion, rarely tacker hernia 4 Absorbable tackers For initial 1 year 5 Fibrin Glue Suitable for inguinal hernia ?Ventral Hernia: Alternative or Adjunct: needs trial. Closure of Hernia defect to avoid mesh protrusion or displacement To with stand the intra abdominal tangential force and also shearing Force due to abdominal muscle contraction
  • 41. Mesh repair of Incisional Hernia  Why Mesh?  What type of Mesh?  Where to place the Mesh?  How to fix the mesh?  Mesh related complications
  • 42. Mesh Related Complications…  Infection  Surgeon’s nightmare  Intestinal adhesions  Composite mesh for laparoscopic ventral hernia repair  Bowel obstructions  Erosion of the prosthesis into the adjacent hollow viscus  Contraction of prosthesis  At least 5cm larger than the size of the defect
  • 43. Prevention of Mesh infection Consider  Patient factors  Smoking  DM  Obesity  Re operation  Big incision  Type of Mesh  Macroporous vs microporous  Impregnated mesh  Technique  LapVs Open  On layVs In lay  Prophylactic antibiotics  Avoid unplanned enterotomy  Infected field  Absorbable mesh  Biological mesh Ventral hernia repair •Risk of infection is 3-10% in Open mesh repair •Risk of infection is < 1% in Lap Mesh repair
  • 44. Conclusion  Mesh repair of abdominal wall hernia is the Standard of Care.  Composite mesh has to be used for ventral hernia  Avoid Mesh related complications , if possible
  • 45. Next  Dr.T.G.Gnanasekaran 15min  Open mesh repair and abdominoplasty  Dr.K.V.Durai raj 15min  Laparoscopic mesh repair of incisional hernia  Case scenarios and discussion 10min
  • 46. •21year old lady, •Para 1 •Large Incisional hernia following c-section •Yet to complete her family •SurgeryVs Conservative treatment •Pregnancy after a mesh repair •Mesh repair during C-section Case 1
  • 47. •40 year old obese lady •Abdominal hysterectomy 5 years ago •Incisional Hernia in Lower midline scar •Has Symptomatic Gall stones •Open /Laparoscopic/Combined Case 2
  • 48. •35 year old lady •Laparoscopic hysterectomy 6 months ago •Umbilical Port site Hernia •Why? •SutureVs Mesh? Case 3
  • 49. Endoscopy Conclave One Day Live Endoscopic Workshop & CME 01.09.2013 Sunday, 8am-6pm AC Auditorium-Level V @ Lotus hospital, Erode Hosted by IMA TN SB- AMS Wing IMA Erode Branch ASI Erode City Chapter Delegates: Rs:1000/- Postgraduates: Rs: 500/-