17. Protocols for IVF GnRH Antagonist Protocols GnRH Agonist Protocols 225 IU per day (150 IU Europe) Individualized Dosing of FSH/HMG 250 g per day antagonist Individualized Dosing of FSH/HMG GnRHa 1.0 mg per day up to 21 days 0.5 mg per day of GnRHa 225 IU per day (150 IU Europe) Day 6 of FSH/HMG Day of hCG Day 1 of FSH/HMG Day 6 of FSH/HMG Day of hCG 7 – 8 days after estimated ovulation Down regulation Day 2 or 3 of menses Day 1 FSH/HMG OCP
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22. The protocol was criticized for being unphysiological, and increases the LH levels in the early stages of the follicular phase, which might be harmful to the growing follicles.
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25. A meta analysis of 22 randomized trials comparing long and short protocols demonstrated the superiority of the long protocol of GnRH agonist regarding clinical pregnancy rate. (Daya 1999)
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29. Type of Gonadotropin / / / 3% glycoproteins 97% other proteins FSH 75 I.U LH 75 I.U. + detectable amounts of hCG
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37. Live Birth / Ongoing Pregnancy rate O.R.: 1.21 (95% CI 0.95-1.54)
HYPOTHALAMUS is a thumb-sized area in the base of the brain that controls many body functions and regulates the pituitary gland. PITUITARY GLAND is a finger-tip sized gland beneath the hypothalamus.