Tomorrow's Wearables
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Wearables are said to be the next computing frontier. However, the smart wristbands and other wearables of today are beset with lack of functionality beyond step counting. This presentation takes us into the future of wearable technology which will enables us to monitor our health, administer medication on-the-go, and potentially transforme today's health care systems.
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Tomorrow's Wearables
- 1. + Tomorrow’s Wearables Toward an era of mobile wellness and care Eddy Lee, PhD
- 2. + The History of Wearables 3D Accelerometer Heart Rate GPS 1980 Mid 1980s Early 1990s Mid 1990s Late 1990s 2000s Steven Mann and augmented reality
- 3. Wearables Today CONSUMER GADGETS IN THE MARKET
- 4. + $4.6 billion market in 2014 3D Accelerometer Heart Rate Motion co-processor challenges wristbands Basis acquired for $100 million Apple Watch began shipping in April $3.1 billion Estimated IPO valuation Today: Wristbands
- 5. + Today: Headbands Brainwave sensing headbands help you monitor your Mood and improve attention span & Focus
- 6. + Today: Eyewear Augmented reality complement live views $2B acquisition by Facebook for virtual reality
- 7. +Meta Glasses Meta is the next generation of smart glasses https://www.youtube.com/watch?v=b7I7JuQXttw
- 8. Future Wearables TRENDS AND TECHNOLOGY
- 9. + Future Trends Product will serve different age groups or specific needs Trend 1: Niche markets Trend 2: Mobile & Therapeutic Product will provide 24/7 assistance, and replace certain visits to the clinic
- 10. + Wearables for the aged Exoskeleton that helps elderly Stock price surged 178% on opening day
- 11. + Smart Clothes for Fitness & Daily Lives 3D Accelerometer Heart Rate GPS Shirts made of smart fibers to measure you heart rate, ECG, skin temperature and muscle activity with electrode sensors
- 12. + Smart Tattoos for the Truly Mobile Super-thin electronics communicate with devices, and measure muscle and brain activities. Google patent application
- 13. + Wearables for Babies E-textile that monitors baby’s sleeping position, temperature, heart rate, oxygen levels and wet diapers
- 14. + How young is too young?
- 15. +Scanadu Lab-At-Home can replace doctor visits https://www.youtube.com/watch?v=gSxNjTXfgBo
- 16. + Wearables for Chronic Conditions Tiggerfish intraocular pressure, powered by induction circuits, made from graphene and silver nanowires display. Contacts measure glucose-level in tears Contact lenses that slowly release pain killers, antibiotics, and anti-inflammatory drugs
- 17. + Wearables for Neuromodulation Thync targets nerves and facial muscles to modulate alertness, and emotion ReliefBand, FDA-approved electrically relieve nausea, and vomiting
- 18. + Wearables for Drug Compliance Future platforms will track drug metabolism. Proteus is a drug adherence platform based on an ingestible sensor made of magnesium and copper
- 19. + Wearables to see our insides SmartPill is an intestinal sensor that measures pressure, pH, temperature and gases as it travels through the gastrointestinal (GI) tract.
- 20. + Pre-natal diagnosis by attracting fetal stem cells to arm patch Wearables for Pre-natal Checkup Eddy Lee et al. Molecular Human Reproduction
- 21. How do we get there AKA WHAT INVESTORS ARE LOOKING FOR
- 22. +Needed: Cross-Disciplinary Science System Design SmartPills Chemistry Health ScienceWireless Pill Data Science
- 23. +Needed: Cognition Science Analytic companies that offer cognition-as-a-service or CaaS Virtual Assistant provides 24/7 chronic disease management. IBM’s Watson understands human languages
- 24. +Needed: Genetic Diagnosis We will need miniature devices to detect RNA, proteomics at home Xu et al from Harvard Science 2015 High throughput screening
- 25. +Needed: Biological energy NanoRibbons let beating hearts power their own pacemakers Glucose-driven lenses has electronics to derive power from blood
- 26. + The Message Interdisciplinary Miniaturization Continuous Diagnosis Therapeutic Mobile & 24/7 Data Science
- 27. Acknowledgements Davis Masten Walter de Brouwer Julia Hu David Sze Pierre Fournier Collin West Kevin Talbot
- 28. + Bios Eddy Lee, PhD Head of Investments at Fenox Venture Capital Consulting Professor at Stanford University Eddy Lee, PhD invests in IT and Health Tech startups.To date, he has invested in more than 50 startups predominately in the US, Singapore and Indonesia. Investment areas include mobile health, big data and marketplaces. Apart from establishing enterprise partnerships, supporting product development, and enabling M&A exits of portfolio companies, Eddy helps startups enter international markets such as the US, Japan, Singapore and Indonesia. He is also a board member at Sense.ly which provides virtual doctor consultation. At a concurrent appointment at Stanford University, Eddy serves as a Consulting Professor at the School of Medicine, where he connects academic projects with commercial opportunities. During his research career at Stanford, Singapore and Australia, he devised medical imaging technology for visualizing stem cell migration and therapy. And while at Marvell and Lucent, he designed semiconductor circuits for high speed communications. Eddy completed a post-doctoral fellowship at Stanford University, and holds a Ph.D in Bioengineering and a B.Eng in Electrical Engineering. He has been an invited speaker at international conferences.
Editor's Notes
- Steve Mann at the University of Toronto Mann has been described as the "father of wearable computing". Self portraits of the ‘digital eye glass’ Let’s not be distracted by his fashion preference in the late 90s, but anyway, not to be distracted, evolve into meta which I would talk about in a sec. Chief Scientist of Meta
- Steve Mann at the University of Toronto Mann has been described as the "father of wearable computing". Self portraits of the ‘digital eye glass’ Let’s not be distracted by his fashion preference in the late 90s, but anyway, not to be distracted, evolve into meta which I would talk about in a sec. Chief Scientist of Meta
- Fastword to the year 2014. Today we are seeing an explosion of wearables for fitness, for work and for everyday use
- We know fitbit, jawbone up, Lark . Can I have a show of hands has one of these. There has been an explosion of smartwatch or smart wristbands on the market. I last counting more than 50. This market is fulled by Intel’s acquisition of Basis for around a $100M. This industry faces extreme competition. Nike has just announced that they are leaving the fuelband market and collaborating with Apple. Importantly, a little know fact is that Apple’s M7 which is in every phone 5s, and the Samsun equivalent called the S health in the galaxy S5 can eliminate wristbands. Companies have to move themselves out from the crowd. full disclosure I’m an investor in Lark which is a Start X companies. Julia Hu is an awesome CEO. Announce a partnership with Samsung. Basis: Heart rate, skin temperature, perspiration, steps In September the world held its breath as Tim Cook say one more thing. And revealed Apple watch. I held my breath too as I wonder would all my prediction about the future of wearables would be blown away by just one thing.
- Headbands is a way to measure focus and concentration. With apps to measure and improve your focus. Muse at $300 has 7 eeg channles to high resolution measurement and also track beyong attention spance by measuring mood, brain acivity https://www.kickstarter.com/projects/806146824/melon-a-headband-and-mobile-app-to-measure-your-fo http://www.interaxon.ca/muse/ Melon is at $99
- Earphones are being manufactured with biometric sensors that can measure heart beat data. Viton Health, Singapore-based startup makes firmware for devices that analyze heart beat data in a new way. Most health trackers and earphones on the market simply give you a measure of heart rate. VH’s tech goes beyond this -- directly assesses your health and measures deviation from optimal health level. Also provides feedback on how to improve. Another interesting startup is Well Being Digital (Hong Kong). Also makes firmware for devices. Proprietary tech to calculate heart beat data. Infrared light shines on skin to calculate heart rate. But when you’re exercising, skin wobbles so light bouncing back is unpredictable. WBD removes the noise, resulting in much more accurate data measurement.
- SXSW
- Eyewear is another cateogory that is emerging is eyewear and the most popular is the google glass. Google glass is great but is is effective a 2ndscreen experience. On the other hand, VR provided by Oculus which just got bought up by Facebook for $2B What is also interesting to me is to combination of the two as demonstrated by Meta. See an over lay aka heads up display A lot has to be done. Remember Sarah Slocum, a lot has to be done to make these glasses
- Eyewear is another cateogory that is emerging is eyewear and the most popular is the google glass. Google glass is great but is is effective a 2ndscreen experience. On the other hand, VR provided by Oculus which just got bought up by Facebook for $2B What is also interesting to me is to combination of the two as demonstrated by Meta. See an over lay aka heads up display A lot has to be done. Remember Sarah Slocum, a lot has to be done to make these glasses
- I have provided a mini over view of the state of art, but let’s now look at the trends in the wearables industry to see what might be some device that you or I will be using 5 years from now. I will be showing some devices that are already in the market, but they are a good indication about the new products to come.
- Wearables for the aged. It is like the exoskeleton much like the suit used by the Iron Man. Enable the immobile and aged to walk easily. Allow regular people or the military to carry heavy loads. This suit from Cyberdyne a company that was IPO just end of March it’s share priced surges almost 2X.
- Right after the smart writst bands and glasses, shirts can be the next big thing. Already we have omsignal, athos which raised $3M from social and capital. These are devices that can monitor our heart rate movement and importantly breathing. Eg, omsignal’s shirts has two piezo bands which during brea Breathing is an important bodily function that we can actually override consciously and have significant impact over our bodily functions. The autonomic nervous system, which mean just like digestion, and may other metabolic activieis that we cannot control. Breathing is special because although part of the autonomic nervous system, it is one that when overrideen has profound impact on our wellness. Heart rate drops, heart rate variebility drops, prespiraiton drops. Stress dips. http://www.breathing.com/articles/autonomic-nervous-system.htm thing the extension of the two bands laets thm measure your breathe volume, and regulatiry.
- In the 70s, there were these pins that you could wear and inform others about your interests Love rock, love hiking, you guys can get together sometimes. That is one idea Then there is Ringblingz which changes colors bases on your cell notifications. Here’s an idea. I would like to see a startup that caters to the Tween. Combine the location aware. You can add a twist there you cannot see your own color.
- And hey, they are wearables for babies too. "New parents want to know how their baby is doing at all times," says Lipoma. "This can tell you if your baby is on her stomach or her back, if her temperature spikes, if she's moving around, and if she's breathing normally." That last factor, of course, is a major fear for parents, who worry about sudden infant death syndrome, or SIDs. There is also the Tweet Pee by Huggies. It’s an experimental product out in the Brazil market where you literally can receive a tweet when the baby pees. And there http://mchips.com/products/products_drugdelivery.html In drug delivery, there are several fundamental challenges: •Long-term storage and protection of the compound •Appropriate delivery (i.e., timing and pharmacokinetics) •Release of precise amounts of a compound at desired intervals •Compliance to prescribed therapy Currently, the ideal drug is one that: •Requires multiple microgram to milligram doses for treatment •Can be stored in lyophilized or liquid form •Is designed for injection delivery Precise, long- term drug delivery can be achieved by using individual microreservoirs to store and hermetically protect the drug, microchip activation to release the drug, and telemetry to both control and communicate release. This creates the opportunity for more accurate dosing, reduced cost-of-care, improved patient compliance and, ultimately, improved patient outcomes. MicroCHIPS, Inc. is pioneering intelligent implanted devices designed to improve the health of millions of people with chronic conditions that require careful monitoring and precise therapy. Based on proprietary microreservoir technology first developed at the Massachusetts Institute of Technology, MicroCHIPS' platform incorporates long-term implant technologies and wireless communications, as well as expertise in protein and peptide formulation for challenging delivery conditions. The result is a device that can provide or enhance patient treatment without direct intervention by either the patient or caregiver. This has the potential to improve patients lifestyle and outcomes as well as reduce healthcare costs by delivering therapy outside of traditional point-of-care. MicroCHIPS was founded with technology developed in the laboratories of Professor Michael Cima and Professor Robert Langer of the Massachusetts Institute of Technology. Dr. Cima and Dr. Langer founded the company with Terry McGuire of Polaris Venture Partners and John Santini. With a management team experienced in launching innovative medical products, the company has attracted leading venture and corporate investors including: Polaris Venture Partners, Medtronic, Intersouth Partners, Flybridge Capital Partners, InterWest Partners, Novartis Venture Fund, CSK Ventures, Saints Capital, Care Capital and Boston University.
- Here’s another niche. People who don’t mind implanting things under their skin. I predict that in 5 years time, implanting electronics under the skin will become more acceptable.
- Eyewear is another cateogory that is emerging is eyewear and the most popular is the google glass. Google glass is great but is is effective a 2ndscreen experience. On the other hand, VR provided by Oculus which just got bought up by Facebook for $2B What is also interesting to me is to combination of the two as demonstrated by Meta. See an over lay aka heads up display A lot has to be done. Remember Sarah Slocum, a lot has to be done to make these glasses
- Google contacts provides glucose measurements Tiggerfish project puts an inductive loop to power the contact, and transparent circuits made of graphene and silver nano wire for heads up display. Smart contacrt will also be a way to dispense drugs. And contact will provide full field of view capacilities, rather tanwhat is affordable by google glassm Smart contact lenses are no longer science fiction. In the last few years we have covered several smart contact lenses with different purposes. One of these electronic contact lenses is the Sensimed Triggerfish, a device capable of continuous measurement of the intra-ocular pressure (IOP). It is the first of its kind, since current measurements of IOP, like applanation tonometry and air-puff tonometry, can only give us the IOP at a certain moment, whereas the Triggerfish can monitor the course of the IOP throughoutthe day. As we write this, the Triggerfish is already being clinically tested. Further on the horizon, the interplay of blood pressure (BP), intracranial pressure (ICP) and IOP may open the door to understanding the circadian ocular perfusion pressure and trans-lamina cribrosa pressure, both thought to be implicated in the pathophysiology of glaucoma. But determining the correct drug treatment depends upon first knowing when during the day the intraocular pressure (IOP) peaks. . “The standard today is to place patients in a laboratory for 24 hours,” says Mr Wismer. During this time a patient's IOP can be measured every few hours using a standard machine called a Goldmann tonometer. But although this approach can measure the IOP very effectively, it is unable to do so continuously. An induction loop is used to power the device and to relay data from the lens to a receiver worn by the patient.
- There will be wearable to complement pre-natal check up. In high risk fetus of genetic disorder, typically an amniocentesis is performed to draw small amount of amniotic fluid for genetic tests on the cells from the fetus. However, this carries a 1% chance of miscarriage. It is well known that cells from the unborn fetus travel to the mother’s blood stream. But these cells are very rare and you will need large amounts of mother’s blood to discover one in order to have whole genome sequencing. But with a suitable patch that causes a minor skin irriration, fetal cells can be concentrated and lifted for genetic diagnosis.
- An extremely costly item on our health tech is the lack of compliance and the attempt to mitigate. There are sms dservices or people call. But a sell monitoring This idea of edible technology has crossed over from sci-fi to reality to address the troubling fact that over half of all drugs worldwide are prescribed, dispensed, or sold inappropriately, according to the World Health Organization. Last July, the Food and Drug Administration approved Proteus Digital Health's ingestible biosensor and its companion patch as the world's first "smart pill" system, Helius. The pill is embedded with a tiny sensor made from silicon and natural ingredients. The patients are taking blood pressure drug Diovan and the study organizers track their compliance via Proteus’ “chip in the pill” technology, which reports to a receiver sensor on the patient’s shoulder when the medication has been ingested. The study has improved compliance from 30 percent to 80 percent after six months, according to Novartis. The charge is detected through the patient’s body by a sensing patch on the patient’s skin. The patch records the time and date that the pill is digested and also measures some vitals like heart rate, activity and respiratory patterns. The information is then sent to the patient’s mobile phone and then onto the internet for caregivers to review and analyze. Proteus’ Raisin technology runs on an electric charge generated by the patient’s stomach acid. At Proteus we believe that the drug is the plug. Proteus makes a computer chip made from food ingredients specifically designed to be co-manufactured with drugs at ultra-low cost. Proteus-enabled products deliver medicine combined with information, education and motivation at prices that are highly affordable for health systems and consumers. Read more: http://www.crunchbase.com/company/proteus-biomedical#ixzz2kebD2yss Follow us: @crunchbase on Twitter | crunchbase on Facebook How big is the ingestible sensor? What is it made of? The sensor resembles a grain of sand in size and make-up—measuring 1mm square and made mostly of silicon. Does the ingestible sensor contain a battery? The ingestible sensor does not contain a battery; it contains two conductive materials, one on either side. When these get wet in your stomach, they power the sensor for a short amount of time. This works just like a potato battery. Seed Sensor 2011-ongoing The ‘Seed Sensor’ is a swallowable device that detects gas fluctuations in the body (methane, carbon dioxide etc) that may be a symptom of undiagnosed disease. The ‘seed’ is a swallowable tablet that unfolds like a flower once in the small intestine deploying a sensitive membrane which captures particles of gas as it moves through the digestive tract. The aim of the project is to achieve a less invasive biomedical application where current applications are still relatively rudimentary. The form and user interface of the Seed Sensor are being designed through an art practice approach that utilises iterative models and workshop-style hands-on brainstorming to generate possible forms for the device. http://www.elasticfield.com/seedsensor.htm
- We will see camera pills that check out inide. The evolution of camera pills Just as the smartphone was an evolutionary step up from the digital camera, smart pills represent the evolution of capsule endoscopy -- those tiny camera pills that were approved by the FDA more than a decade ago. Camera pills are generally used to record videos for gastrointestinal treatments, but they lack Proteus' sophisticated sensors. Given Imaging (NASDAQ: GIVN ) , a major manufacturer of camera pills, recognized this market shift and acquired SmartPill Corporation's Smart Pill GI Monitoring System last October for $6 million. The SmartPill uses sensors to measure pH levels, pressure, and temperature in the gastrointestinal tract. It can also measure total gastrointestinal transit times to better evaluate disorders like gastroparesis and constipation. Demand for Given Imaging's pill technologies is rising; last quarter, the company reported that earnings and revenue rose 70.7% and 11.1%, respectively, from the prior-year quarter. Shares are up more than 30% over the past 12 months.
- What kind of scientific breakthrough is needed is get us there
- There’s a trend that wearables require knowledge from multiple disciplines in science. Let’s use the Smart Pill as an example that (Health Science) Need pills to monitor body functions, especially in elderly who may forget to take medication. Can also track heart rate, mobility, sleep, etc. Replaces radiation. (Hardware) Swallow the pill. Made of ingredients found in food and activates upon ingestion. Taken alongside medication to capture exact time of ingestion. Pill is slightly larger than multi-vitamin. (Materials Science) No battery or antenna on pill. Stomach fluids (HCl) complete the power source (copper and magnesium) and body transmits number generated by sensor (Hardware) Patch is worn on stomach , receives and captures info from pill—heart rate, activity, rest, etc.– sends info to mobile device (Software) Securely access applications that display your data in context and support care in variety of ways
- Alme for healthcare combines an intricate natural language model with the simple, friendly interface of an avatar - or virtual health assistant (VHA)- to drive interactive conversations with users on their channel of choice. The tool is currently targeted at pharmaceutical companies, healthcare providers, government organizations and accountable care organizations. Next IT hopes that they will then make its tools available to consumers. http://techcrunch.com/2013/10/10/next-it-launches-alme-for-healthcare-a-virtual-assistant-for-chronic-disease-management/ url- http://www.nextit.com/healthcare/ Add: Google investment
- To accomplish point 4, we need miniature or mobile equipment to measure traces of RNA, proteomics or minerals in the patient's body. New methods of detecting trace substances may thus be needed. Break down complex biological samples into individual components.
- http://news.cnet.com/8301-17938_105-57617483-1/nanoribbons-let-beating-hearts-power-their-own-pacemakers/ Researchers show that materials called piezoelectric, packaged onto flexible strips attached to animal hearts, can supply power for medical devices where batteries pose problems. Url- http://pubs.acs.org/doi/pdf/10.1021/ac4006793 A microscale membrane-less biofuel cell, capable of generating electrical energy from human lachrymal liquid, was developed by using ascorbate and oxygen naturally present in the tear as fuel and oxidant The biodevice is based on three-dimensional nanostructured gold electrodes covered with abiotic (conductive organic complex) and biological (redox enzyme) materials functioning as efficient anodic and cathodic catalysts, respectively.
- Need another example of devices driven by our body’s movement, thermal energy or the surround audio energy http://illuminatingbodies.wordpress.com/category/design/wearable/therapeutic-jewellery/ The Diabetes Neckpiece is a wearable applicator device to apply Nanotechnology Victoria’s NanoMAPs to the skin. NanoMAPs are small (10 x 2mm) circular discs which have an array of micro needles on their surface. They allow for pain-free delivery of insulin to the body, replacing syringes. The Diabetes Rings work in conjunction with the Diabetes Neckpiece. The rings are designed to keep the nano engineered insulin patches against the skin once they have been applied. They are designed as discreet housings for therapeutics. Philosophically, they question how we might ‘enable’ our favourite jewellery/artefacts with functionality above and beyond the aesthetic.The Diabetes Jewellery project was developed through my Subtle Technologies residency with Nanotechnology Victoria in 2007-8.
- The future of wearable looks brights
- I would to take this opportunity to share a couple of things about Fenox. We are based out of the valley but has just incorporated the regional subsidiary here. We invest in consumer Internet, enterprise and health tech. So far we have invested in Tech In Asia and JFDI. We are on the look out for the most motivated individuals to join our young team either here in Singapore or the Indonesia office. We already have a regional manager who travels between Jakarta and here. There is part-time and full time opportunity. Depending on experience, we are offer junior positions such as internship to senior roles such as venture partner or general partner. Come and talk to me to find out more.