This document summarizes a journal article on toxic anterior segment syndrome (TASS). TASS is a non-infectious inflammatory reaction caused by a toxic substance entering the anterior segment during eye surgery. Common causes include preservatives inadvertently injected into the eye, detergents or residues left on instruments, and contaminated water or solutions. TASS presents with pain, blurred vision, eye redness, and severe anterior segment inflammation including corneal edema and hypopyon. Treatment involves topical steroids, but prevention through proper sterilization and use of preservative-free solutions is key to avoiding this complication.

1. Journal Club June 14, 2006 Terry J. Alexandrou, MD Department of Ophthalmology and Visual Science University of Chicago

2. Toxic Anterior Segment Syndrome Review/Update Mamalis N, Edelhauser HF, Dawson DG, Chew J, LeBoyer RM, Werner L. J Cataract Refract Surg 2006; 32:324-333. Journal Club Terry J. Alexandrou, MD Department of Ophthalmology and Visual Science University of Chicago

6. Etiology of TASS Causes numerous and varied

13. B S S E N Z Y M E SEM TEM

19. Clinical Findings of TASS Anterior segment inflammation typically severe Hypopyon

20. Clinical Findings of TASS Anterior segment inflammation typically severe Diffuse limbal to limbal corneal edema

21. Clinical Findings of TASS Severe cases of TASS Fibrin Formation

22. Clinical Findings of TASS May result in TM damage - Secondary glaucoma Fibrin Formation

28. Delayed Onset TASS Small globules formed in the anterior chamber

29. Delayed Onset TASS Oily material coating the anterior surface of the IOL

30. Delayed Onset TASS Theorized that use of postoperative topical ointment containing petroleum as well as tight patching allowed ingress of the material into the anterior chamber

31. Treatment