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BIONLP09
and
CRFs




 Farzaneh Sarafraz

 18 February 2009

                      
BioNLP'09

        Event rather than entity
    



        Most entities are given
    



        3 tasks
    


        −   Event detection and characterization
        −   Event argument recognition
        −   Negations and speculations



                                   
Example
    quot;I kappa B/MAD­3 masks the nuclear localization 
      signal of NF­kappa B p65 and requires the 
      transactivation domain to inhibit NF­kappa B 
      p65 DNA binding. quot;


    Event: negative regulation
    Trigger: masks
    Theme1: the first p65
    Cause: MAD­3
    Site: nuclear localization signal

                             
Example
    quot;In contrast, NF­kappa B p50 alone fails to 
      stimulate kappa B­directed transcription, and 
      based on prior in vitro studies, is not 
      directly regulated by I kappa B. quot;


    Event: regulation
    Theme1: this p50
    Trigger: regulated
    Negation: true for this event
    Speculation: none

                             
HMM and MEMM

                              (X1, X2, ...)
    Observations
                              (Y1, Y2, ...)
    labels
        p(Xi , Yi) 
    



        X  ranges over observation sequence 
        Y ranges over and label sequence
        Requires independence assumption
    



        i.e. each item is labelled independently

                                  
Conditional Random Field

        p(Y |X)
    



        Y: label sequence
        X: observation sequence
        Maximise p
    




                                   
MMEM Label Bias Problem

        Probability given the current state
    


        −   Transitions leaving a state compete against
                 each other
             



                 not all states
             



        −   Per­state normalization
        −   Probability bias towards states with few transitions
        −   Demonstrated experimentall


                                       
Label Bias Example

     Training data:



     −   A B C D
     −   A B D D
     −   A B C E
     −   A B D C
     Model says:



     −   C > D 50%
     −   C > E 50%
     Why predict E when D is much more common?
                          
CRF Solution

        Model probability of transitions and probability 
    


        of states
        CRFs
    


        −   Models probability of transition between states
        −   Probability is conditional on current observation
        −   Not normalised
        −   Considers many quot;featuresquot; of observations


                                     
Features

        quot;edge featuresquot; as well as quot;vertex featuresquot;
    


        −   Word is capitalized
        −   Word ends in quot;­ingquot;
        −   Label is quot;proper nounquot;
        Features are important!
    




                                      
End.




        

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Crf

  • 2. BioNLP'09 Event rather than entity  Most entities are given  3 tasks  − Event detection and characterization − Event argument recognition − Negations and speculations    
  • 3. Example quot;I kappa B/MAD­3 masks the nuclear localization  signal of NF­kappa B p65 and requires the  transactivation domain to inhibit NF­kappa B  p65 DNA binding. quot; Event: negative regulation Trigger: masks Theme1: the first p65 Cause: MAD­3 Site: nuclear localization signal    
  • 4. Example quot;In contrast, NF­kappa B p50 alone fails to  stimulate kappa B­directed transcription, and  based on prior in vitro studies, is not  directly regulated by I kappa B. quot; Event: regulation Theme1: this p50 Trigger: regulated Negation: true for this event Speculation: none    
  • 5. HMM and MEMM (X1, X2, ...) Observations (Y1, Y2, ...) labels p(Xi , Yi)   X  ranges over observation sequence  Y ranges over and label sequence Requires independence assumption  i.e. each item is labelled independently    
  • 6. Conditional Random Field p(Y |X)  Y: label sequence X: observation sequence Maximise p     
  • 7. MMEM Label Bias Problem Probability given the current state  − Transitions leaving a state compete against each other  not all states  − Per­state normalization − Probability bias towards states with few transitions − Demonstrated experimentall    
  • 8. Label Bias Example Training data:  − A B C D − A B D D − A B C E − A B D C Model says:  − C > D 50% − C > E 50% Why predict E when D is much more common?    
  • 9. CRF Solution Model probability of transitions and probability   of states CRFs  − Models probability of transition between states − Probability is conditional on current observation − Not normalised − Considers many quot;featuresquot; of observations    
  • 10. Features quot;edge featuresquot; as well as quot;vertex featuresquot;  − Word is capitalized − Word ends in quot;­ingquot; − Label is quot;proper nounquot; Features are important!     
  • 11. End.