7. 1986 : BOSNIAK CLASSIFICATION , 4 CATEGORIES
1993 : MODIFIED BOSNIAK CLASSIFICATION ,ADDED
ADDITIONAL CATEGORY II F
8. CATEGORY I
Benign lesions
Thin wall
Well defined interface with parenchyma
No septations
No calcification
Density : 0 – 20 HU
No enhancement
Example – Simple renal cyst
9. CATEGORY II
Cysts complicated by prior infection or haemorrhage
Benign cystic lesion with hairline thin septa
Fine calcification in walls/ septa
Atleast one fourth of the lesion’s circumference should extend outside the
kidney so that the smoothness of the wall can be evaluated
Minimal perceived post contrast enhancement
Non enhancing high attenuation (40-100 HU) lesion < 3 cm in diameter
11. CATEGORY II F
F = Follow up
More complex cyst
Increase in number of septa
and calcifications
Non enhancing high
attenuation lesions > 3 cm
May advance to category III
with time and require 6
month follow up
12. CATEGORY III
Indeterminate cystic masses
Thick, irregular calcification in walls or septa
Irregular borders
Thickened or enhancing septa
Uniform wall thickening or that contain small non enhancing nodules
Examples –
multilocular cystic nephroma
lymphangioma
hydatid cyst
cystic renal cell carcinoma
13.
14. CATEGORY IV
Malignant cystic masses
Shaggy thickened walls
Thick septations
Coarse calcifications
Density > 20 HU
Enhancing
Example – Renal cell carcinoma
15.
16. S
I II IIF III IV
DENSITY WATER Water
density or
40-100 HU
(<3 CM
SIZE)
40-100 HU
(>3CM)
WALL HAIRLINE
THIN
THIN MAY BE
THICKENED
THICKENED
SEPTA _ FEW
HAIRLINE
THIN
MULTIPLE
HAIRLINE
THIN,MAY BE
THICKENED
THICKENED
CALCIFICATION _ THIN
(<1MM) IN
WALL/
SEPTA
CAN BE
THICK/
NODULAR
NODULAR
THICK
SOLID
COMPONENT
_ _ _ +/- +
ENHANCEMENT _ _ _ WALL +
SEPTA+
SOLID -
ENHANCING
SOFT TISSUE
COMPONENT
RISK OF 1.7 18.5 > 18.5 33 92.5
17.
18. WORKING INTERPRETATION OF BOSNIAK
CLASSIFICATION
CATEGORY I
We know it’s a cyst
CATEGORY II
We are still pretty certain it’s a cyst
CATEGORY III
We don’t know what it is
CATEGORY IV
Its probably a tumor
22. HOW USEFUL IS BOSNIAK
CLASSIFICATION?
It accurately identifies Category I & Category IV lesions
There are inter observer variations in Category II & Category III
lesions
Cannot efficiently characterize Category III lesions
23. INTERPRETATION PITFALLS
A small lesion with the same number and type of septa as a
large lesion will appear more complex.
Enhancement of hyperdense or heavily calcified lesions is
difficult to assess, especially when the lesion is small
Pseudoenhancement occurs when a cyst (generally < 2 cm)
is surrounded by enhancing parenchyma during peak
enhancement and artifactually appears to enhance. It should
be suspected when a lesion is homogeneous and measures
less than 10 HU on an unenhanced scan.
Rarely lymphoma, myomatous hamartoma , RCC and
metastasis measure greater than 20 HU on unenhanced scans.
26. ULTRASOUND
Differentiates between solid and cystic lesions
Features of cyst are
(a)Anechoic
(b) Posterior acoustic enhancement
(c) Sharply marginated smooth walls
Cyst septations yield strong back
echoes and may create reverberation
artifacts within the cyst.
Calcification within the cyst may cause
shadowing.
27. COLOR DOPPLER
To assess the vascularity
Vascularity within a nodule or septum greatly increases the
likelihood of malignancy.
28. TISSUE HARMONIC IMAGING
Hemorragic or proteinaceous cysts may contain low level
echoes or even layers of echoes.
THI helps in confirming this by eliminating dirty echoes
within an otherwise pristine cyst.
USG CAN BE EMPLOYEDTO DIRECT PERCUTANEOUS
THERAPIES SUCH AS RFA AND CRYOTHERAPY OF
COMPLEX RENAL LESIONS.
30. CONTRAST ENHANCED USG MAY BE
HELPFUL IN PATIENTSWHO REQUIRE
FOLLOW UPTO REDUCETHE RADIATION
EXPOSURE
CEUSG IS APPROPRIATE IN THE BOSNIAK CLASSIFICATION OF
RENAL CYSTS
31. PITFALLS OF USG
Can miss carcinoma within a cluster of cysts
Vascular malformations may mimic cysts
Artifactual echoes
Complex cyst require further evaluation
32. COMPUTED TOMOGRAPHY
TECHNIQUE
Pre and post contrast images
2.5 to 5 mm thick slides
Images acquired :
Unenhanced CT
Corticomedullary phase ( 20-30 seconds)
Nephrographic phase ( 80-100 seconds)
Delayed ( 10 minutes )
33. CHANGE IN ATTENUATION INTERPRETATION
< 10 HU TYPICAL OF BENIGN CYST
VERY RARELY RENAL CYSTIC TUMOR
10-15 HU SUSPICIOUS FOR MALIGNANCY
COULD BE DUE TO VOLUME AVERAGING,
IMPERFECT PLACEMENT OF REGION OF
INTEREST, MOTION ARTIFACT
>15 HU PATHOLOGICAL PROCESS : MALIGNANCY,
CYSTIC ANGIOMYOLIPOMA , ONCOCYTOMA ,
INFECTIONS
34. ROLE OF DUAL ENERGY CT SCAN
DECT has ability to identify presence of iodine in body
tissues
We can generate virtual noncontrast images to reproduce the
baseline unenhanced attenuation, this allows reduction in
radiation doses.
It is also possible to produce an “iodine overlay,” in which the
presence of iodine in the tissues is indicated by a
superimposed color map
In this we do not rely on increase in attenuation to measure
enhancement instead,we directly visualise the presence of
iodine in lesion.
35. Since renal cysts do not have blood flow,an iodine-overlay
image should show a cyst as devoid of iodine signal
This method may prove beneficial beyond the current
practice of determining enhancement in a renal mass because
it has potential to reduce the effect of renal cyst
pseudoenhancement.
37. MAGNETIC RESONANCE IMAGING
TECHNIQUE
T1W Gradient echo : high signal protein ,hemorrage , fat
T2W HASTE : septa or nodules within the cystic fluid
POST CONTRASTT1W Serial images at 5,10,20 minutes
38. MAGNETIC RESONANCE IMAGING
ADVANTAGES :Demonstrates
additional septa
wall/septal thickening
Enhancement
Superior contrast resolution
Enhancement within a calcified cystic lesion : calcification is usually less
apparent on MRI thus making enhancement more apparent.
Substraction imaging : hemorragic cysts appear hyperintense on bothT1 and
T2 and don’t enhance after contrast administration. Substraction imaging can
help in identifying presence of enhancement in these high signal lesions.
DISADVANTAGES
Poor in demonstrating calcifications
39.
40. RENAL CYST PUNCTURE AND ASPIRATION
Ultrasound or CT guided
Of doubtful utility
INDICATIONS
Infected cyst – diagnostic or therapeutic
Indeterminate cyst on USG/CT
Decompression
DISADVANTAGES
Though if positive confirms malignancy but
a negative aspirate doesn’t rule out
malignancy
Multiloculated cyst
Risk of needle track seeding
43. SIMPLE RENAL CYSTS
MC renal masses
ETIOLOGY
Probably secondary to
tubular obstruction
IVU
Radiolucent mass
Pencil thin wall
Claw or beak sign
USG
Anechoic with posterior
acoustic enhancement
44. CT CRITERIA MRI CRITERIA
Sharp margination and
demarcation from
surrounding renal
parenchyma
Smooth thin wall
Homogenous water density
content (0-20 HU)
No contrast enhancement
Sharp margination and
demarcation from
surrounding renal
parenchyma
Smooth thin wall
Homogeneous contents
with signal characteristics
of water
No contrast enhancement
45. OCCASIONALLY A, SOLID RENALTUMORS MAY
OBSTRUCTTHETUBULES OF ADJACENT NORMAL
RENAL PARENCHYMA RESULTING INTUBULAR
DILATATION AND SECONDARY CYST FORMATION
( SENTINEL CYST ). THEREFOREWHENEVER A SIMPLE
CYST IS DETECTED,THE ADJACENT PARENCHYMA
SHOULD BE CAREFULLY EVALUATED FORTHE
PRESENCE OF AN ADJACENT SOLID MASS.
46. COMPLEX CYSTS
Anything which is not a simple cyst
RADIOLOGICAL FINDINGS
Thick wall
Irregularity at the base of the cyst
Septations
Calcifications
High attenuation values
Contrast enhancement
47. HEMORRHAGIC CYST
Cyst containing blood
Common in
polycystic renal disease
malignant cysts
trauma
Presentation - acute or insidious
Most hemorrhagic cysts < 3 cm are benign
RADIOLOGICAL FINDINGS
1. Hyperdense cyst
2. Settling debris
3. MRI – most commonly hyperintense onT1 andT2 weighted
sequences.They may show fluid-iron levels because of dependant
settling of methemoglobin containing sediments.
48. POLYCYSTIC KIDNEYS
If you can count the number of cysts, they are simple
cysts ; if you can’t, it’s polycystic
CHILDHOOD POLYCYSTIC DISEASE
AR
Ectasia of renal collecting ducts
Subtypes :
Perinatal
Neonatal
Infantile
Juvenile
Associations –
Oligohydramnios
Potter’s syndrome
Respiratory failure
Periportal fibrosis (sequelae) causing PHTN
49. Tubular ectasia is confined mainly to the renal medulla with
only occasional macrocysts
Renal cortex is less severely affected
Severity of disease is inversely related to age of the patient
Hepatic and renal involvement are inversely proportional to
each other.
50. IVU : striated
nephrogram due to
accumulation of
contrast in dilated
tubules
USG: Diffusely
echogenic kidneys
51. NCCT – smooth, enlarged kidneys, low in attenuation due to
large fluid volume in dilated ducts
CECT – Striated nephrogram, hepatic fibrosis and features of
portal hypertension
52. ADULT POLYCYSTIC KIDNEYS
AD
Pathology : cysts of varying size gradually replace renal
parenchyma
C/F :
Presents between 20 and 39 years
Hypertension
Renal insufficiency
Hematuria
Renal stones
Complications of multiple cysts
53. Associated with cysts in liver > pancreas > brain> spleen >
ovaries > testes
Associated with cardiac valvular disorders , abdominal and
inguinal hernias, aneurysm of cerebral and coronary arteries
Colonic diverticula : 80%
54. SPIDERY COLLECTING
SYSTEM WITH STRETCHED
CALYCES
NUMEROUS SMOOTHLY
MARGINATED
RADIOLUCENCIES
THROUGHOUT THE CORTEX
AND MEDULLA (SWISS
CHEESE APPEARNCE).
56. The risk of renal cancer in patients with
ADPKD who are not undergoing dialysis is
not increased.However patients undergoing
dialysis are at greater risk for development
of renal malignancy relative to general
population.
62. D/D
Multiple simple cysts (less diffuse, no family history)
Von Hippel-Lindau disease (cerebellar hemangioblastoma,
retinal hemangiomas, occasionally pheochromocytomas)
Acquired uremic cystic disease (kidneys small, no renal
function, transplant)
Infantile PCKD (usually microscopic cysts)
63. MULTICYSTIC DYSPLASTIC
KIDNEYS
MC cystic disease in infants
M > F
Females have higher chances of bilateral
disease
May be associated with contralateral
abnormalities like obstruction of the
ureteropelvic junction,renal agenesis,renal
hypoplasia,VUR
May be associated with cleft palate, ductal
plate malformation of the liver,cardiac
abnormalities
64. MECHANISM :
In utero failure of ureteric
bud to connect with the
nephrons in the metanephric
blastaema
PATHOLOGY :
Kidney – non functioning and
converted into a multicystic
dysplastic mass
Ureter – atretic
Renal artery – hypoplastic/
atretic
65. TYPES
Pelvoinfundibular atresia : no discernible renal pelvis is seen.
Kidney may be small/normal or enlarged. Contains multiple
non communicating cysts.No exretion of contrast by kidneys.
No perfusion on renal scintigraphy.
Hydronephrotic type : Dilatation of renal pelvis and calyces
with parenchymal cysts that donot communicate with the
collecting system
66. Newborn shows no normal renal parenchyma and the
right renal fossa filled with multiple simple appearing
cystic structures c/w MCDK. The cysts did NOT
communicate thereby excluding hydronephrosis
68. MULTILOCULAR CYSTIC NEPHROMA
Tumor of primitive renal tissue
originating from metanephric
blastaema
Pathology – cyst with septa that
contain renal tissue of variable
maturity
Bimodal age distribution.
Under the age of 5 years, cystic
nephroma occurs most frequently in
males, whereas the adult group has a
female predominance (91%) and
mean age of 55 years
69. Septate cystic mass with
multiple loculations,
hairlike septa,peripheral
and curvilinear
calcifications,irregular
borders, and minimal
contrast enhancement.
Extension into the
central sinus and into the
renal pelvis can also be
found
70. IVU – Multiple non enhancing areas bulging into renal pelvis
USG/CT/MRI –
Well defined multiloculated mass with an apparent capsule
Little or no enhancement
Calcification is usually not a feature
74. UNILATERAL/LOCALISED RENAL CYSTIC
DISEASE
One kidney is replaced by renal cysts and other kidney is
normal.
Represents dilated ducts and tubules
No liver cysts, No renal failure, normal excretion of contrast
75. Cysts are seen to be
separated by enhancing
bands of normal renal
parenchyma.
Individual smaller cysts are
often present in the renal
parenchyma adjacent to
main loculated mass.
76.
77. LOCALIZED CYSTIC
DISEASE CYSTIC NEOPLASM
Unencapsulated : no
capsule between cluster of
cysts and renal parenchyma
Several small parenchymal
cysts not contained within
the main cluster of cysts
No mural irregularities
Encapsulated
Mural irregularities may be
present
78. Localized cystic disease
of kidney with multiple
simple cysts separated by
attenuated enhancing
renal tissue (arrow).
Well-encapsulated mass in
middle portion of left
kidney with multiple
enhancing septae (solid
arrow). Mass of cystic
locules is encompassed in
single large encapsulated
mass (open arrow).
Enhancing tissue seen in
lesion represents tumor
tissue.
79. ACQUIRED CYSTIC DISEASE OF KIDNEY
INCIDENCE :
Upto 80% of patients on chronic hemodialysis or peritoneal
dialysis develop renal cysts
Usually after 5-10 years of HD
8-16% develop neoplasm
80. CT is modality of choice
Multiple small or
moderate size cysts
Affected kidneys are
small
Atleast 3 cysts in each
kidney who has CRF not
due to hereditary renal
cystic disease
Cysts both in cortex and
medulla
81. There is increased incidence of RCC in patients undergoing
dialysis.
Small RCC is more common than large masses
More in males as compared to females
82. CYSTS SECONDARY TO NON MALIGNANT RENAL
PATHOLOGY
OBLITERATIVE PYELONEPHRITIS
Constriction of major or minor calyx produces
cyst like structures
Similar appearance seen in tuberculosis
84. CLOSED CYST
Have an intact cyst lining and
adventitia and do not
communicate with the renal
collecting system
Rounded mass (with or without
calcification) causing elongation
and splaying of the infundibula
and calyces and, occasionally,
obliteration of one or more
calyces from pressure.
85. PSEUDOCLOSED CYST
Exposed cyst with absence
of pericyst; the cyst is in
close contact with urine.
Contrast media can
interpose itself in crescent-
like fashion in the space
between the laminated
ectocyst and the pericyst,
producing the "goblet" or
"wine-glass" sign
(Surraco's sign)
86. OPEN TYPE
Resulting from rupture
and discharge of daughter
cysts
Communicating with the
renal collecting system,
contrast medium from
either an intravenous or
retrograde urogram can
spread around the cyst or
fill it
87. In this open type of hydatid cyst, an intermittent or permanent
communication exists between the hydatid and the
pyelocalyceal system so that contrast medium flows directly
into the cyst. Usually there is a typical mottled appearance of
contrast, insinuating itself among a mass of daughter cysts
but, occasionally, if the cyst contents are tightly packed, the
contrast will be compressed between the contents and cyst
wall to produce an extensive false crescent sign.
88.
89. MILK OF CALCIUM RENAL CYST
Not a true cyst
Communicating or closed off calyceal diverticulum
Lined with trasitional epithelium
Contains particulate colloidal suspension of various calcium salts
Plain X ray
Supine position – full moon sign
Horizontal beam – half moon
US/CT/MRI
Half moon shift
90. Echogenic debris layering at the dependent part of a small cyst. There
is change in the fluid-debris interphase with change in position. There
is minimal acoustic shadowing due to a relatively large amount of
calcium debris.
91. PSEUDOCYST
URINOMA (Uriniferous Perirenal Pseudocyst)
Any obstructive process may cause extravasation into perirenal spaces
Wall is formed by the fibrous capsule
May cause secondary ureteral obstrction
92. CALYCEAL CYST (DIVERTICULUM)
An intraparenchymal cavity lined by transitional
epithelium which communicates with a minor
calyx, either centrally or at fornix
Do not receive any drainage from nephrons
IVU – well defined opaque rounded area adjacent
but peripheral to a minor calyx
D/D – small cyst & hydrocalyx
RISK – calculus, infection & hematuria
95. RENAL SINUS CYSTS/
EXTRAPARENCHYMAL
PARAPELVIC CYST – simple renal cyst originating from the
renal parenchyma, which are primarily expanding within the renal
sinus
PERIPELVIC CYST – cysts originating from the sinus
structures. Most likely lymphatic in origin
96. PARAPELVIC CYST
Usually single or few
Resemble simple renal cortical cyst in morphology
May cause compression of the pelvicalyceal system resulting
in hydronephrosis
97. PERIPELVIC CYST
Usually bilateral
Lymphatic in origin
Multilocular or unilocular
Water attenuation cysts closely abutting pelvis and
infundibuli
Don’t communicate with renal collecting system
102. CYSTIC RENAL CELL CARCINOMA
About 10% of RCC mainfest as fluid filled cystic mass
FOUR PATTERNS
Intrinsic unilocular cystic growth
Intrinsic multilocular cystic growth
Origin in the epithelium of a simple cyst
Cystic necrotic tumor
103. Cystic RCC is seen on MRI and CT as a water-attenuation
mass with an enhancing thick wall or septa sometimes with
associated soft-tissue nodules
Nodular and septal enhancement is the most sensitive
finding to discriminate cystic RCC from complex benign
lesions .
104.
105. MULTILOCULAR CYSTIC RCC
20-76 years of age
Low grade tumor
Characterized by septate variably sized cysts separated from
the kidney by a fibrous capsule.The cyst fluid may be serous
or hemorrhagic and thus can be of water attenuation or
higher.
Asymmetric septal thickening may be seen
May show septal or wall calcification
106. Cystic clear cell carcinoma is distinguished from multilocular
cystic RCC by the presence of fewer loculations,thicker and
more nodular septa, and expansile
enhancing mural nodules.
107. MIXED EPITHELIAL AND STROMAL
TUMOR
Benign neoplasm
Characterized by a biphasic proliferation of epithelium and
stroma and admixed solid and cystic regions that have
variable cellularity and growth patterns.
Tumor nearly always occurs in women (≈ 7:33 male-to-
female ratio), especially in perimenopausal women (median
age, 52 years
Bosniak III or IV lesion with septa, curvilinear calcifications,
and a delayed enhancing solid component.Areas ofT2
hypointensity suggesting fibrotic component may be seen.