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The Models of Alzheimer's Disease Part III

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Jimmy Lu
Jimmy Lu

Speaker: Jimmy Lu Topics: The Models of Alzheimer's Disease Part III Date: 2011.03.26 WECO Lab, CSIE, FJU

Technology
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The Models of Alzheimer’s Disease (Part III) Speaker : Jimmy Lu Advisor : Hsing Mei Web Computing Laboratory (WECO Lab) Computer Science and Information Engineering Department Fu Jen Catholic University
Outline Cholinergic hypothesis Cholinergic pathways Target attack model
Cholinergic Hypothesis
Cholinergic Hypothesis
Cholinergic pathways
Cholinergic pathways Pathways defined by McGeer Medial forebrain system Parabrachial complex Reticular system Striatalinternerons Moto neurclei
Cholinergic pathways
Cholinergic pathways
Cholinergic pathways MarselMesulam defined 8 major cholinergic sectors
Cholinergic pathways
Cholinergic pathways
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Cortical Hubs vs. AD
Target Attack Model
Reference Paul T Francis, Alan M Palmer, Michael Snape, Gordon K Wilcock, The cholinergic hypothesis of Alzheimer’s disease: a review of progress, J Neurol Neurosurg Psychiatry(1999) 66:137–147. Alexander G. Karczmar, Cholinergic Cells and Pathways, Exploring the Vertebrate Central Cholinergic Nervous System, Springer, New York (2007), pp. 33–79. Albert R, Baraba’ si AL. Statistical mechanics of complex networks, Rev Mod Physics (2002), 74: 47–97. Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer’s disease. J Neurosci. (2009), 29(6):1860–1873.

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