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surgical anatomy of breast & management of advanced carcinoma breast
- 1. Presented by: Dr. Sk. Sabir Ahmed Chairperson: Prof. Dr. Chikkannachari
- 38. Stage 3a N2a =met to ipsilat axillary node , fixed or matted N2b= met to ipsilat int mammary node in absence of ax. node T o N2 M o T1 N2 Mo T2 N2 Mo T3 N1 Mo T3 N2 Mo
- 39. Stage 3b T4a= extension to chest wall T4b= edema(Peaud’ Orange), T4c= both T4a & T4b T4d= inflammatory carcinoma T4 No Mo T4 N1 Mo T4 N2 Mo T4 N2 Mo
- 40. Stage 3 c N3a= met to ipsilat infraclavicular LN N3b= ipsilat Internal mammary & axillary LN N3c= ipsilat supraclavicular LN Any T N3 Mo
- 53. Class Common examples Clinical use Selective estrogen receptor modulator(SERMS) Tamoxifen, Raloxifen, Toremifen Adjuvant therapy for metasttic disease Aromatase inhibitors(AIs) Anastrazole Letrozole Exemestane Adjuvant therapy for metasttic disease Pure antiestrogen Lutinizing hormone- releasing hormone(LHRH) Fluvistrant Goserelin Leuprolide -2 nd line therapy for metastatic disease -Adjuvant therapy for metasttic disease Progestational agents Megestrol 2 nd line therapy for metastatic disease Androgens Fluoxymesterone 3 rd line therapy for metastatic disease High dose estrogens Diethylstilbestrol 3 rd line therapy for metastatic disease
Editor's Notes
- Over 75% of women who are diagnosed with breast cancer are age 50 or older. Men can get breast cancer, although this is very rare. For every man who is diagnosed, over 100 women are found to have breast cancer. Most women — about 80% — who get breast cancer do not have a sister or mother who has breast cancer. Excluding skin cancer, breast cancer is the most common cancer in women. 1990s the breast cancer death rate declined by the largest amount in over 65 years. Heart disease is the leading killer of women. Approx 97% of women diagnosed with breast ca at an early stage survive 5 yrs or more. There is no single cause of breast cancer. Research has shown that several different factors increase the risk of breast cancer. Genetic and lifestyle differences increase the risk for some cancers.