Sickle Cell Anemia

SICKLE CELL ANEMIA PRESENTED BY: HAFSA MARYAM 4 TH YEAR

[object Object],[object Object],[object Object],[object Object],[object Object],HISTORY James B. Herrick

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SICKLE CELL DISEASE TYPES OF SICKLE CELL DISEASE

[object Object],SICKLE CEL ANEMIA OTHER NAMES 1.HbSS disease 2.SS disease

[object Object],[object Object],HbS

SICKLE CEEL TRAIT ,[object Object],[object Object],[object Object],[object Object],AS

[object Object],[object Object],[object Object],INHERITENCE Normal Sickle cell trait Sickle cell anemia

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PATHOPHYSIOLOGY

Beta chains bind with other beta chains polymerization VASO-OCCLUSIVE CRISIS

10-20 days LIFE SPAN OF SICKLE CELLS

[object Object],[object Object],NO SYMPTOMS IN INFANTS ??? HbF

[object Object],[object Object],[object Object],[object Object],CLINICAL MANIFESTATIONS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],VASO-OCCLUSIVE CRISIS

[object Object],[object Object],[object Object],This crisis is triggered by parvovirus B19 infection. APLASTIC CRISIS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SEQUESTRATION CRISIS

[object Object],[object Object],[object Object],[object Object],[object Object],HEMOLYTIC CRISIS

[object Object],[object Object],[object Object],[object Object],FACTORS AFFECTING SEVERITY

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],COMMON SYMPTOMS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],COMPLICATIONS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],COMPLICATIONS

SYMPTOMS Pain Visual blurring Neurological symptoms Syncope Infection Neck stiffness and headache Weakness and pallor Family Hx and Hx of transfusion Dactylitis Leg ulcers Jaundice

Dactylitis Dying tissue of leg Leg ulcer Small remnant of spleen Conditions

[object Object],[object Object],[object Object],[object Object],DIAGNOSIS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],TYPES OF CELLS IN SMEAR RBC MORPHOLOGY Sickle cell Target cell Howell jolly body

[object Object],[object Object],[object Object],SICKLING TEST Cells with HbS Cells with HbA ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],Hb ELECTROPHORESIS Sickle cell anemia normal Sickle cell trait AFSC

[object Object],[object Object],[object Object],[object Object],[object Object],IMAGING STUDIES: Pneumonia Or Acute chest syndrome

Avascular necrosis of hip bone Marrow expansion

[object Object],[object Object],[object Object],[object Object],TREATMENT

[object Object],[object Object],[object Object],[object Object],PROGNOSIS

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PREVENTION

Sickle Cell Anemia

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to Sickle Cell Anemia

Similar to Sickle Cell Anemia (20)

Recently uploaded

Recently uploaded (20)

Sickle Cell Anemia