Ludwig’s angina is a life-threatening infection with associated compromised airway and is an emergency in OMFS. Airway management is the primary concern in this situation
5. First described in 1836 by Wilhelm Frederick von Ludwig as
a cellulitis of fast evolution involving the region of the
submandibular gland which is disseminated through
anatomic contiguity without tendency towards abscess
formation
3 Fs
It was to be feared
Rarely became fluctuant
Often was fatal
LUDWIG’S ANGINA (LATIN TERM ANGERE = “TO STRANGLE”)
6. Grodinsky stated in a 1939 paper that Ludwig’s angina was
a unique deep neck abscess characterized by
occurrence bilaterally in more than one space,
production of gangrenous serosanguineous infiltration with or
without pus,
involvement of connective tissue and muscle but not glandular
structures,
Spread by continuity, not via lymphatics
Airway compromise has been recognised as the leading
cause of death
Mortality rate – 50% in preantibiotic era
8% currently
LUDWIG’S ANGINA
7. Dental caries, recent dental treatment, poor dental
hygiene (accounts for 75-90% of cases)
Trauma: mandibular fracture, facial trauma, tongue
piercing, frenuloplasty
Infections of oral malignancy
Submandibular sialadenitis
Systemic compromise such as AIDS, glomerulonephritis,
diabetes mellitus, aplastic anemia, transplant recipients,
chemotherapy; IVDA (Soares et al. and Tavares et al.)
ETIOLOGY
9. Bilateral ‘wood like’ swelling in the submandibular,
sublingual and submental spaces
Double chin appearance
Skin is tense and tends to pit and blanch on pressure
Rapidly spreading edema
Edema and congestion of floor of the mouth
Elevation and protrusion of tongue
Elevation of the tongue is associated with dysphagia,
odynophagia, dysphonia and cyanosis
CLINICAL FEATURES
10. Dyspnea in supine position impending laryngeal edema
Dysphagia and drooling of saliva
Septicemia
High grade fever
Malaise
Body aches
Leukocytosis
CLINICAL FEATURES
Thumb sign on epiglottis indicating
laryngeal edema
11. Staphylococcus aureus in the pre-antibiotic era
Change in the microbial flora – aerobic streptococcal species
and nonstreptococcal anaerobes
The bacteria that commonly cause deep neck infections
represent the normal oral flora that becomes pathogenic when
normal host defenses are ineffective
MICROBIOLOGY
Oral Maxillofacial Surg Clin N Am 20 (2008) 353–365
12. Common organisms
•Streptococcus viridans
•Streptococcus milleri
group species
•B-hemolytic
streptococci
•Neisseria species
•Peptostreptococcus
•Coagulase-negative
staphylococci
•Bacteroides
Should be
considered but are
uncommon
•Bartonella henselae
•Mycobacterium
tuberculosis
Anaerobic bacteria
•Prevotella and
Porphyromonas species
•Actinomyces species
•Bacteroides species
•Propionobacterium
•Hemophilus
•Eikenella
MICROBIOLOGY
Oral Maxillofacial Surg Clin N Am 20 (2008) 353–365
In diabetic patients, the microbial nature of DSNI shows a higher infection rate
of Klebsiella pneumoniae when compared with those who do not have diabetes
mellitus
13. Laboratory tests – hemogram, blood glucose, etc.
Panoramic x-ray – to identify possible odontogenic sources
Cervical, profile and posterior-anterior radiographs – to
observe the volume increasing in the soft tissues and any
deviation of the trachea
Ultra sound has been recommended to differentiate
between cellulitis, abscess and adenopathy in head and
neck infection
USG has a sensitivity of 95% and specificity of 75%
INVESTIGATIONS
14. INVESTIGATIONS
Measure the distance from the
anterior aspect of the vertebral
body to the air column of the
posterior pharyngeal wall.
At the level of C-2, 7mm
At the level of C-6,
22 mm in adults and
14mm in children .
Jain et al. Deep-neck space infections – a diagnostic dilemma! Indian J.
Otolaryngol. Head Neck Surg. 350 (October–December 2008) 60:349–352
15. CT scan is most widely used modality
Readily available, can localize abscesses in the head
and neck
Not as effective as ultrasound in determining abscess
from cellulitis
Cellulitis appears as soft-tissue swelling, increased
density of surrounding fat, enhancement of involved
muscles and obliteration of fat planes
Abscess low density area with a peripheral
enhancement
CT has been reported to have sensitivity of 91% and
specifi city of 60%
CT
16. Ultrasonography is very sensitive in detecting fluid
collection
Quick, widely available, relatively inexpensive, painless
Involves no radiation
An effective diagnostic tool to confirm abscess
formation in the superficial facial spaces and is highly
predictable in detecting the stage of infection
ULTRASOUND
S. Pallagatti et al. / European Journal of Radiology 81 (2012) 1821–1827
17. Sufficient airway
management
Early and aggressive
antibiotic therapy
Incision and
drainage for any
who fail medical
management or
form localized
abscesses
Adequate nutrition
and hydration
support
TREATMENT GOALS
Chou Y Lee Y, Chao H: An upper airway obstruction emergency: Ludwig’s angina, Pediatr
Emerg Care 23:892-896, 2007.
18. Airway management in Ludwig’s angina can be
challenging
No consensus regarding the airway management in the
available literature
Suggested methods include tracheostomy, conventional
laryngoscopy and intubation (after administration of
muscle relaxant), awake blind nasal intubation and
awake fibreoptic intubation.
AIRWAY MANAGEMENT
19. Tracheostomy using local anaesthesia was considered as
the gold standard in the past
Risk of the spread of infection to the mediastinum,
aspiration of pus, rupture of the innominate artery,
spread of infection to the thorax, airway loss and
tracheal stenosis
Blind nasal intubation (BNI) is questionable because of
infrequent success on first pass and increased trauma
with repeated attempts might necessitate emergency
cricothyrotomy
AIRWAY MANAGEMENT
20. The first successful fibreoptic nasotracheal intubation in a
patient was first reported in the year 1974 (Schwartz et al)
Fibreoptic intubation is a sophisticated and less invasive
method of securing airway in patients with deep neck
infection
AIRWAY MANAGEMENT
21. Airway Advantages Disadvantages
Close clinical
observation
• No mechanical
intervention
• Unrecognized impending
airway loss
• Risk of oversedation with
loss of airway
• Extension of infection and
edema leading to
asphyxiation
Endotracheal
intubation
• Speed with which airway
control is achieved
• Nonsurgical procedure
• Potential for failed
intubation,
• Inability to bypass upper
airway obstruction
• Requirement for
mechanical ventilation
• Subglottic stenosis
• ET displacement
Tracheostomy • Allows for bypass of upper
airway obstruction
• Very secure airway
• Less need for sedation
and mechanical
ventilation
• Earlier transfer out of CCU
• Surgical procedure with
inherent risks
• Pneumothorax
• Bleeding, subglottic
stenosis, tracheoinnominate
or tracheoesophageal
fistula, unsightly scar
24. Intravenous access, fluid resuscitation, and administration
of IV antibiotics
Antibiotic therapy should be administered empirically and
tailored to culture and sensitivity results
Antibiotic therapy should be administered empirically and
tailored to culture and sensitivity results
Other regimens –
Penicillins with β-lactamase inhibitor,
Second, third, or fourth generation Cephalosporins and
Metranidazole
MEDICAL MANAGEMENT
25. Ampicillin/Sulbactam and clindamycin – effective for
anaerobic infections
Pipercillin/Tazobactam has shown efficacy in treating
polymicrobial infections as a single agent
Comorbid medical conditions require thorough workup
and monitoring because they can be exacerbated by the
infection, and can also lead to more severe infections
Addition of gentamicin to the empirical therapy should be
strongly considered for diabetic patients
Control of blood sugar below 200 mg/dL is imperative for
good control of infection
MEDICAL MANAGEMENT
26. Principles (Topazian & Goldberg)
Incise in healthy skin and mucosa when possible, not at
the site of maximum fluctuance, because these wounds
tend to heal with an unsightly scar;
Place the incision in a natural skin fold;
Place the incision in a dependent position;
Dissect bluntly;
Place a drain; and
Remove drains when drainage becomes minimal
SURGICAL TREATMENT
27. Bilateral submandibular incisions as well as a midline
submental incision
Incision approximately 3 to 4 cm below the angle of the
mandible and below the inferior extent of swelling
roughly parallel to the inferior border of mandible
INCISION & DRAINAGE
28. Ludwig’s angina is a life-threatening infection
Early diagnosis and immediate treatment is the key for successful
management
Antibiotic therapy should be administered empirically and
tailored to culture and sensitivity results
Prompt and early surgical intervention is required to provide a
higher control of the patient’s health.
CONCLUSION
29. Topazian RG, Goldberg MH, Hupp JR. Oral and Maxillofacial
Infections. 4th ed. Philadelphia, Pa: W. B. Saunders; 2002.
Bagheri SC, Bell RB, Khan HA. Current Therapy in Oral and
Maxillofacial Surgery - Saunders; 1 edition;2011
Osborn et al. Deep space neck infection. Oral Maxillofacial Surg
Clin N Am 20 (2008) 353–365
Bahl, et al.: Microflora in odontogenic infections. Contemporary
Clinical Dentistry | Jul-Sep 2014 | Vol 5 | Issue 3
S. Pallagatti et al. / European Journal of Radiology 81 (2012) 1821–
1827
Jain et al. Deep-neck space infections – a diagnostic dilemma!
Indian J. Otolaryngol. Head Neck Surg. (October–December 2008)
60:349–352
M.M. Wolfe et al. Surgical airway in deep neck infections and
ludwig angina. Journal of Critical Care (2011) 26, 11–14
Potter, Herford, and Ellis. Tracheotomy Versus Endotracheal
Intubation for Airway Management in Deep Neck Space
Infections.J Oral Maxillofac Surg 60:349-354, 2002
REFERENCES
Editor's Notes
The sublingual glands, deep lobes and ducts of the submandibular glands, lingual arteries, nerves and veins, V3 branches from the trigeminal nerve, genioglossus, geniohyoid, styloglossus, palatoglossus, hyoglossus, and fat
superficial lobes of the submandibular glands, anterior bellies of the diagastric muscles, and level 1A and 1B lymph nodes.
Rarely used coz of 33% false negative rates
Of 29 patients, 6 (20%) had symptoms consistent with true Ludwig angina. 19(65.5%) had
evidence of airway compromise. 8(42%) of these 19 patients required advanced airway control
techniques. No patient required a surgical airway, and no mortality resulted from airway compromise.
Advance airway control techniques were required more often in patients with airway compromise
IV antibiotics (immunocompetent patients)
Ampicillin/sulbactam 2 g IV q4hr
Penicillin G 2-4 MU IV q4-6hr plus metronidazole 500 mg IV q6hr
Clindamycin 600 mg IV q6hr for PCN allergy
IV antibiotics (immunocompromised host)
Cefotaxime 2 g IV q6hr
Ceftizoxime 3 g IV q8hr
Imipenem 500 mg IV q6hr
Piperacillin-tazobactam 3.375 g q6hr
Dexamethasone 10 mg IV x1, then 4 mg q6hr x48hr
o Nebulized epinephrine 1 ml of 1:1000 diluted to 5 ml with 0.9% NS