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TRIGEMINAL
NERVE
(tri-three; gemini-twins)
-- Hardik Vora
Guided by-
Dr. Manjunath
Largest cranial nerve
Mixed -- Small motor root
Large sensory root
Nerve of the first pharyngeal arch
 Exteroceptive from
Skin of the face & forehead;
Mucous membrane of the
nasal cavity;
Oral cavity;
Nasal sinus;
Floor of mouth, teeth;
Anterior 2/3 of tongue;
Cranial dura
Proprioception
from
 Teeth;
 Periodontium;
 Hard palate;
 TMJ
Attached to lateral part of pons
Sensory root (portio major)
Motor root (portio minor)
Fibers arise from Semilunar Ganglion
Semilunar ganglion
– Develops from neural crest
– Crescent shaped
– Unipolar neurons
– Location- Meckel’s cavity; superior to petrous
part of temporal bone
Afferent station
Afferent fibers accompany fibers of motor root
Proprioception from TMJ, periodontal
membrane, teeth, hard palate
Afferent impulses from stretch receptors in the
muscles of mastication
Located at midpontine level
Medial to main sensory nucleus
Fibres distribute to muscles of mastication,
mylohyoid, anterior belly of digastric, tensor
tympani, tensor veli palatini.
Location – midpons
Forms dorsal trigeminothalamic tract
Ascending fibers terminate in this nucleus
Convey light touch, tactile discrimination,
sense of position and passive movements
True sensory ganglion
Contains cells that are structurally and
functionally ganglion cells
Convey GP input from the muscles innervated
by the trigeminal nerve and the extraocular
muscles, as well as from the periodontal
ligament of the teeth
Largest nucleus
Extends caudally from main nucleus to level
C3 of spinal cord
Forms ventral trigeminothalamic tract
Conveys pain and temperature
extends to the
pontomedullary
junction inferiorly
pontomedullary
junction to obex
Obex(medulla) to C3
level of spinal cord
Tactile sense Pain and temperature
Smallest division
From anterior medial part of semilunar
ganglion  lateral wall of cavernous sinus
Sensory fibres from
Scalp, skin of forehead, upper eyelid lining frontal
sinus, conjunctiva of eyeball, lacrimal gland, skin
of the lateral angle of eyeball & lining of ethmoid
cell
Ophthalmic division
Nervous
tentori
Supratrochlear
Supraorbital
Long
ciliary n.Short
ciliary
nerves
Infratrochlear
Sensory
From lower eyelid, side of the nose,
upper lip;
All maxillary teeth & gingivae, mucous
membrane of most of nasal cavity, hard
and soft palate;
Tonsillar region and region of pharynx
Sphenopalatine
ganglion
Sphenopalatine ganglion
Parasympathetic ganglion
Stellate; lies deep in
pterygopalatine fossa
Associated with greater petrosal
nerve- branch of facial nerve
Relays secretomotor impulse from
facial nerve
Suspended from V2 by 2 roots
In 1988, Dellon & Mackinnon – Sixth
degree injury
Nerve injuries exhibit features of different
degrees of injury
Surgical removal of third molars(Von Arx and
Simpson, 1989; Rood, 1992)
Osteotomies (Walter and Gregg, 1979; Yoshida et
al, 1989)
Trauma (De Man and Bax, 1988)
Tooth extractions (Strassburg, 1967; Hansen, 1980)
Pulpectomy (Holland, 1994)
Experimental Trigeminal Nerve Injury G.R. Holland CROBM 1996 7: 237
Implant placement
Hydroxypatite ridge augmentation
Endodontic surgeries
Tumour resection
Salivary gland and duct surgery
Vestibuloplasty
Biopsy procedures
• Inferior alveolar nerve injury – 0.41-7.5%
• Lingual nerve injury – 0.06-11.5%
Risk factors for nerve injury
Local anesthetic toxicity
Formation of epineural hematoma
Needle-barb mechanism of injury
Chemical injury
Sagittal split osteotomy
Mandibular advancement procedure
osteotomies.
Intraoral vertical ramus osteotomy (IVRO)
Genioplasty procedures
Fracture of mandibular body and ramus
LeFort I & II fractures
Fracture of condylar segment medially
Mandibular angle, body and symphysis fracture
Inadvertent placement of screws
Pathologic lesions  use of Carnoy’s solution
 Overinstrumentation
 Chemical injury
 Direct trauma from apicoecotomy
TMJ exposures by preauricular approach
Damage is minimized by incision and
dissecting in close apposition to cartilagenous
portion of external auditory meatus
Fracture of neck of condyle
 Trigeminal neuralgia is defined as sudden,
usually unilateral, severe, brief, stabbing,
lancinating type of pain in the distribution of
one or more branches of 5th
cranial nerve
Specific etiology unknown
Sudden, unilateral, intermittent paroxysmal,
sharp, shooting, lancinating, like pain.
Pain is elicited by slight touching superficial
‘Trigger points’
Common triggers include touch, talking, eating,
drinking, chewing, tooth brushing, etc
Monheim’s Local anesthesia and pain control
in dental practice
Handbook of Local Anesthesia - Malamed
Textbook of medical physiology –Guyton
Peterson’s Principles of Oral & Maxillofacial
Surgery
Experimental Trigeminal Nerve Injury G.R.
Holland CROBM 1996 7: 237
Prevention of iatrogenic Inferior alveolar nerve
injuriesin relation to dental procedures. Dent
Update 2010; 37:350-363
J Oral Maxillofac Surg 68:2437-2451, 2010
Frequency of Trigeminal Nerve Injuries
Following Third Molar Removal J Oral Maxillofac
Surg 63:732-735, 2005
14/09/13 69

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Trigeminal nerve

  • 1.
  • 3. Largest cranial nerve Mixed -- Small motor root Large sensory root Nerve of the first pharyngeal arch
  • 4.  Exteroceptive from Skin of the face & forehead; Mucous membrane of the nasal cavity; Oral cavity; Nasal sinus; Floor of mouth, teeth; Anterior 2/3 of tongue; Cranial dura Proprioception from  Teeth;  Periodontium;  Hard palate;  TMJ
  • 5. Attached to lateral part of pons Sensory root (portio major) Motor root (portio minor)
  • 6.
  • 7. Fibers arise from Semilunar Ganglion Semilunar ganglion – Develops from neural crest – Crescent shaped – Unipolar neurons – Location- Meckel’s cavity; superior to petrous part of temporal bone
  • 8.
  • 9.
  • 10.
  • 11. Afferent station Afferent fibers accompany fibers of motor root Proprioception from TMJ, periodontal membrane, teeth, hard palate Afferent impulses from stretch receptors in the muscles of mastication
  • 12.
  • 13.
  • 14. Located at midpontine level Medial to main sensory nucleus Fibres distribute to muscles of mastication, mylohyoid, anterior belly of digastric, tensor tympani, tensor veli palatini.
  • 15. Location – midpons Forms dorsal trigeminothalamic tract Ascending fibers terminate in this nucleus Convey light touch, tactile discrimination, sense of position and passive movements
  • 16. True sensory ganglion Contains cells that are structurally and functionally ganglion cells Convey GP input from the muscles innervated by the trigeminal nerve and the extraocular muscles, as well as from the periodontal ligament of the teeth
  • 17. Largest nucleus Extends caudally from main nucleus to level C3 of spinal cord Forms ventral trigeminothalamic tract Conveys pain and temperature
  • 18. extends to the pontomedullary junction inferiorly pontomedullary junction to obex Obex(medulla) to C3 level of spinal cord Tactile sense Pain and temperature
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28. Smallest division From anterior medial part of semilunar ganglion  lateral wall of cavernous sinus Sensory fibres from Scalp, skin of forehead, upper eyelid lining frontal sinus, conjunctiva of eyeball, lacrimal gland, skin of the lateral angle of eyeball & lining of ethmoid cell
  • 32.
  • 33. Sensory From lower eyelid, side of the nose, upper lip; All maxillary teeth & gingivae, mucous membrane of most of nasal cavity, hard and soft palate; Tonsillar region and region of pharynx
  • 34.
  • 35.
  • 37.
  • 38. Sphenopalatine ganglion Parasympathetic ganglion Stellate; lies deep in pterygopalatine fossa Associated with greater petrosal nerve- branch of facial nerve Relays secretomotor impulse from facial nerve Suspended from V2 by 2 roots
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49.
  • 50.
  • 51. In 1988, Dellon & Mackinnon – Sixth degree injury Nerve injuries exhibit features of different degrees of injury
  • 52. Surgical removal of third molars(Von Arx and Simpson, 1989; Rood, 1992) Osteotomies (Walter and Gregg, 1979; Yoshida et al, 1989) Trauma (De Man and Bax, 1988) Tooth extractions (Strassburg, 1967; Hansen, 1980) Pulpectomy (Holland, 1994) Experimental Trigeminal Nerve Injury G.R. Holland CROBM 1996 7: 237
  • 53. Implant placement Hydroxypatite ridge augmentation Endodontic surgeries Tumour resection Salivary gland and duct surgery Vestibuloplasty Biopsy procedures
  • 54. • Inferior alveolar nerve injury – 0.41-7.5% • Lingual nerve injury – 0.06-11.5%
  • 55.
  • 56. Risk factors for nerve injury
  • 57. Local anesthetic toxicity Formation of epineural hematoma Needle-barb mechanism of injury Chemical injury
  • 58. Sagittal split osteotomy Mandibular advancement procedure osteotomies. Intraoral vertical ramus osteotomy (IVRO) Genioplasty procedures
  • 59.
  • 60. Fracture of mandibular body and ramus LeFort I & II fractures Fracture of condylar segment medially Mandibular angle, body and symphysis fracture Inadvertent placement of screws Pathologic lesions  use of Carnoy’s solution
  • 61.
  • 62.
  • 63.  Overinstrumentation  Chemical injury  Direct trauma from apicoecotomy
  • 64. TMJ exposures by preauricular approach Damage is minimized by incision and dissecting in close apposition to cartilagenous portion of external auditory meatus Fracture of neck of condyle
  • 65.  Trigeminal neuralgia is defined as sudden, usually unilateral, severe, brief, stabbing, lancinating type of pain in the distribution of one or more branches of 5th cranial nerve Specific etiology unknown
  • 66. Sudden, unilateral, intermittent paroxysmal, sharp, shooting, lancinating, like pain. Pain is elicited by slight touching superficial ‘Trigger points’ Common triggers include touch, talking, eating, drinking, chewing, tooth brushing, etc
  • 67. Monheim’s Local anesthesia and pain control in dental practice Handbook of Local Anesthesia - Malamed Textbook of medical physiology –Guyton Peterson’s Principles of Oral & Maxillofacial Surgery
  • 68. Experimental Trigeminal Nerve Injury G.R. Holland CROBM 1996 7: 237 Prevention of iatrogenic Inferior alveolar nerve injuriesin relation to dental procedures. Dent Update 2010; 37:350-363 J Oral Maxillofac Surg 68:2437-2451, 2010 Frequency of Trigeminal Nerve Injuries Following Third Molar Removal J Oral Maxillofac Surg 63:732-735, 2005

Editor's Notes

  1. Vs, trigeminal nerve, afferent root; Mo, efferent root; G.G, gasserian ganglion; M, meningeal branch; I.C, branch to internal carotid artery; Oph, opthalmic nerve; S.M, superior maxillary nerve; I.M, inferior maxillary nerve; III, communication to oculomotor nerve; IV, to trochlear nerve; L, branches to upper eyelid; L.G , long root to lenticular ganglion; Sy, root from sympathetic (on carotid artery); III, short root from motor oculi nerve; C , short ciliary branches; L.C , long ciliary nerves; I.T, infra-trochlear nerve; E.N, external nasal nerve; I.N, internal nasal nerve; O, orbital branch of superior maxillary nerve; L.Gl, lachrymal gland; C, conjuctival branch; L, branch to eyelids and face.
  2. 1-orbital; 2-posterior superior lateral nasal; 3-nasopalatine ; 4-pharyngeal; 5-greater palatine; 6-lesser palatine