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Gluten sensitivity v7.0

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Gluten sensitivity v7.0

  1. 1. “ GLUTEN SENSITIVITY – FACT OR FICTION?” – Harveen K (harveenk26@gmail.com)
  2. 2. AGENDA
  3. 3. GLUTEN SENSITIVITY: FACT OR FICTION?! “Clues to Gluten Sensitivity” published in WSJ (2011) reports case history of three patients. “Coeliac Disease and Gluten Sensitivity” published by Food Reaction (2009) reports case history of a 28 year old woman.All these patients presented with two or more combinations of these symptoms. The All these patients were tested negative for symptoms were dizziness, abdominal pain, coeliac disease and were sent back and nofatigue, migraines, body aches, constipation, treatment was prescribed and temper tantrums
  4. 4. GLUTEN SENSITIVITY: FACT OR FICTION?!”Patients have been told if it wasnt coeliac disease, it wasnt anything. It was all in their heads," says Cynthia Kupper, executive director of the nonprofit Gluten Intolerance Group of North America Were these patients reporting with too vague non-specific symptom? or it wasnt anything?
  5. 5. GLUTEN SENSITIVITY: FACT OR FICTION?! Dietary Dietary Villains.. Villains.. .. Move over fat, salt and sugar. There is anew dietary villain in town and it’s name is GLUTEN
  6. 6. GLUTEN SENSITIVITY: EMERGING DEFINITION“According to the recent definition of the term gluten sensitivity at the 11th “According to the recent definition of the term gluten sensitivity at the 11thInternational Coeliac Disease Symposium in Oslo, Norway in June 2011. Gluten International Coeliac Disease Symposium in Oslo, Norway in June 2011. Glutensensitivity can be indistinguishable from coeliac disease or wheat allergy based sensitivity can be indistinguishable from coeliac disease or wheat allergy basedon symptoms alone. It has been the catch all for people who feel better gluten on symptoms alone. It has been the catch all for people who feel better glutenfree but whose labs don’t fit them into the first two categories” (Sapone et al., free but whose labs don’t fit them into the first two categories” (Sapone et al.,2011) 2011)
  7. 7. GLUTEN SENSITIVITY: SYMPTOMS (Sapone et al., 2011) (Sapone et al., 2011)
  8. 8. GLUTEN SENSITIVITY: DIFFERS FROM COELIAC DISEASE– . Volta U, De Giorgio R, 2012 Volta U, De Giorgio R, 2012
  9. 9. GLUTEN SENSITIVITY: DIAGNOSISThe following list summarizes the theidentificationof Gluten sensitivity The following list summarizes theidentification of Gluten sensitivity The following list summarizes identification of gluten sensitivity: (Sapone et al., 2011) (Sapone et al., 2011)
  10. 10. GLUTEN SENSITIVITY: NEW UNDERSTANDING (Volta U, De Giorgio R, 2012) (Volta U, De Giorgio R, 2012)
  11. 11. GLUTEN SENSITIVITY: EVIDENCE-BASED MEDICAL LITERATUTRE
  12. 12. GLUTEN SENSITIVITY: TREATMENT & PREVENTION
  13. 13. GLUTEN SENSITIVITY: TREATMENT AND PREVENTION (WSJ, 2011) (WSJ, 2011)
  14. 14. GLUTEN SENSITIVITY: FURTHER RECOMMENDATIONS FOR RESEARCH
  15. 15. QUESTIONS? (Easy ones please  )
  16. 16. REFERENCESHadjivassiliou M, Sanders D, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut tobrain. Lancet Neurol 2010; 9: 318–30Jessica R. Biesiekierski, Newnham ED, Irvin PM, Barret JS, Haines M, Doecke DJ, Shepherd SJ, B, Jane G. Gibson PR. GlutenCauses Gastrointestinal Symptoms in Subjects Without Coeliac Disease: A Double-Blind Randomized Placebo-Controlled Tria . Am J Gastroenterol advance online publication, 11 January 2011; doi: 10.1038/ajg.2010.487Sapone A, Bai J, Ciacc C, Dolinse J, HR P Green, Hadjivassiliou M, Kaukinen K, Rostami K, Sander D, Schumann M, Ullrich R,Villalta D, Volta U, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification.BMC Medicine 2012, 10:13 doi:10.1186/1741-7015-10-1.Sapone A, Karen M. Lammers B, Mazzarella G, Mikhailenkoc I, Cartenìa M, Casolarob V, Fasanob A. Differential MucosalIL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy CoeliacDisease. Int Arch Allergy Immunol 2010;152:75–80 DOI: 10.1159/000260087.Sapone A, Karen M. Lammers B, Casolaro V, Cammarota M, Giuliano T, De Rosa M, Stefanile R, Mazzarella G , Russo MI,Esposito P, Ferraraccio F, Cartenì M, Riegler G, Magistris L, Fasano A. Divergence of gut permeability and mucosalimmune gene expression in two gluten-associated conditions: coeliac disease and gluten sensitivity. BMC Medicine2011, 9:23 doi:10.1186/1741-7015-9-23Volta U, Giorgio R. New understanding of gluten Sensitivity. Nature Reviews Gastroenterology & Hepatology 9, 295-299(May 2012) doi: 10.1038/nrgastro.2012.15Wahnschaffe U, Schulzke J, Zeitz M, Ullrich R. Predictors of Clinical Response to Gluten-Free Diet in Patients diagnosedwith diarrhoea-dominant irritable bowel syndrome. Clinical Gastroenterology & Hepatology 2007Coeliac Disease and Gluten Sensitivity. http://www.foodreactions.org/gluten/ accessed on 25.11.2012Clues to Gluten Sensitivity. http://online.wsj.com/article/SB10001424052748704893604576200393522456636.htmlaccessed on 25.11.2012

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