Hospital command center leaders have never had to run an incident response on the scale of the COVID-19 pandemic. Whereas a typical emergency event (e.g., flooding, earthquakes, multivehicle collisions, or shootings) causes rapid patient influx with an identifiable starting and stopping point, the novel coronavirus has an ongoing, inestimable impact. The extensive duration, combined with high transmission risks and a massive scope of impact, demand that health systems prepare for complex facility, equipment, and staffing needs. Their best strategy is to leverage data-driven tools to scale their existing emergency response plans for COVID-19’s unprecedented proportions.