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Justin Aronson: A High School Student and HAS 19 Keynote Who’s Transforming the Understanding of Genetic Variants

According to the next generation of healthcare transformation leaders, data democratization is mission critical for the future of improvement. High school student Justin Aronson explains how he leverages open-source health laboratory data to build a tool that improves the clinical interpretation of sequenced genetic variants. Aronson’s cloud-based data integration and visualization system, Variant Explorer, runs on genomic and phenotype data that’s feely accessible on the public archive ClinVar. He says that large-scale data democratization is the key to current and future healthcare problem solving.

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Justin Aronson: A High School Student and HAS 19 Keynote Who’s Transforming the Understanding of Genetic Variants

  1. 1. Justin Aronson: A High School Student and HAS 19 Keynote Who’s Transforming the Understanding of Genetic Variants
  2. 2. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. JUSTIN ARONSON HAS 19 Keynote Presenter Justin Aronson – Future Healthcare Disruptor This presentation introduces Justin Aronson, an exceptional 10th grader and HAS 19 Keynote presenter who is transforming the understanding of genetic variants. Although Aronson credits geneticist mentors with his accomplishments, the resulting success is grounded in his data tool – Variant Explorer.
  3. 3. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Will data democratization truly transform healthcare? According to a representative from a future generation of healthcare disruptors, the answer is clearly yes. Justin Aronson – Future Healthcare Disruptor
  4. 4. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. In 2014, high school student and HAS 19 keynote presenter Justin Aronson launched Variant Explorer, a cloud-based data integration and visualization system for improving the clinical interpretation of sequenced genetic variants. Aronson credits expert mentors (geneticists Heidi Rheim and Steven Harris) with his achievement, but he says that the real determinant in Variant Explorer’s success is the data he accessed thanks to his data resource’s commitment to open sourcing its asset. Justin Aronson – Future Healthcare Disruptor
  5. 5. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Aronson built Variant Explorer on genomic and phenotype data from the archive ClinVar. As a freely accessible, public record of reports of the relationships among human variations and phenotypes, ClinVar provides public access to information about the relationships between human variation and observed health status. From Open Source to User Experience
  6. 6. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Through displays and data processing, Variant Explorer helps healthcare organizations identify variations in relationships (i.e., conflicts between labs) among the genomic variants and phenotypes, which labs, researchers, and other clinicians submit to ClinVar. From Open Source to User Experience
  7. 7. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. The Variant Explorer homepage prioritizes user experience with three accessible tabs tailored to users: • Search by Submitter • Show Submitter Mega Table • Search by Significance From Open Source to User Experience
  8. 8. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. The tabs make data accessible, and a conflict discrepancy table helps break down data and shows conflict with a high-level overview. Labs visualize and recognize conflicts with other labs and can fix them within own organizations or reach out to others to fix conflicts, with the end goal of improving patient care. From Open Source to User Experience
  9. 9. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Aronson is now looking to machine learning to increase Variant Explorer functionality. Specifically, he aims to reformat ClinVar data to make it more conducive to machine learning and then leverage the advanced analytics capability to show more sophisticated relationships between disparate lab data. Aronson says that ClinVare data is currently extremely complex, and while a great resource for labs to see a lot of information, it doesn’t support machine learning. An Eye on Machine Learning
  10. 10. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. By simplifying ClinVar data structure for machine learning use with Variant Explorer, Aronson would also open source the data for other users to leverage machine learning. Skeptics in the data community have told Aronson that his machine learning goal is too ambitious, but he’s moving forward with an eye to the future. An Eye on Machine Learning Maybe it doesn’t work out but I think that even by failing at incorporating machine learning in Variant Explorer, I’ll learn a lot more about machine learning and be able to use it for [other] projects.” - Justin Aronson
  11. 11. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Aronson explains that the ClinVar commitment to data democratization has not only enabled his work with Variant Explorer but serves as a great example of how open-source data is key to solving and facing the increasingly complex problems of today and future. Data Democratization Will Drive the Future of Healthcare I hope these larger corporations embrace data democratization because I think it’s key to how we, as a society, will move forward,” - Justin Aronson
  12. 12. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. For more information: “This book is a fantastic piece of work” – Robert Lindeman MD, FAAP, Chief Physician Quality Officer
  13. 13. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. More about this topic Link to original article for a more in-depth discussion. Justin Aronson: A High School Student and HAS 19 Keynote Who’s Transforming the Understanding of Genetic Variants No More Excuses: We Need Disruptive Innovation in Healthcare Now Marie Dunn Transforming Healthcare Analytics: Five Critical Steps Ann Tinker, MSN, RN, Professional Services, Sr. VP; Dan Hopkins, Professional Services, VP The Surprising Benefits of Bad Healthcare Data Dan Lowder , Analytics, VP Cloud-Based Open-Platform Data Solutions: The Best Way to Meet Today’s Growing Health Data Demands Jared Crapo, Sales, Sr. VP; Linda Simovic, Principal Program Manager, Azure for Health and Life Sciences Machine Learning Using Healthcare.ai Levi Thatcher, VP, Data Science; Michael Mastanduno, PhD, Data Scientist
  14. 14. © 2018 Health Catalyst Proprietary. Feel free to share but we would appreciate a Health Catalyst citation. Other Clinical Quality Improvement Resources Click to read additional information at www.healthcatalyst.com Health Catalyst is a mission-driven data warehousing, analytics and outcomes-improvement company that helps healthcare organizations of all sizes improve clinical, financial, and operational outcomes needed to improve population health and accountable care. Our proven enterprise data warehouse (EDW) and analytics platform helps improve quality, add efficiency and lower costs in support of more than 65 million patients for organizations ranging from the largest US health system to forward-thinking physician practices. Health Catalyst was recently named as the leader in the enterprise healthcare BI market in improvement by KLAS, and has received numerous best-place-to work awards including Modern Healthcare in 2013, 2014, and 2015, as well as other recognitions such as “Best Place to work for Millenials, and a “Best Perks for Women.”

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