Precision medicine has profound implications for patient care and clinical outcomes, and is already beginning to impact everyday medical practice. However, implementation faces several obstacles, including overstated claims, resistance among clinical medicine thought leaders and providers, and concerns about costs, data overload, and interoperability. This webinar will address five key concerns, challenges, and barriers among clinicians and IT professionals struggling to determine the value and limitations of implementing precision medicine, and offer tangible recommendations to help drive toward precision medicine adoption. Learning Objectives: Identify obstacles that impede the implementation of precision medicine in clinical practice. Contrast population-based medicine and precision medicine. Demonstrate the real world benefits of precision medicine in today's healthcare setting.

1. Realizing the Promise
of Precision Medicine
John D. Halamka, MD, MS - Professor of Medicine,
Harvard Medical School; CIO, Beth Israel Deaconess
Eric Just - Senior Vice President, Product
Development, Clinical Analytics and
Decision Support, Health Catalyst

2. © 2018
Health
Catalyst
• What are the differences?
• What data is needed?
• What analytical techniques are appropriate?
Personalized or Precision?
22

3. © 2018
Health
Catalyst
Real World Examples
3
• My wife’s cancer care and recent insurance company
adventures
• My hypertension treatment
• My father’s multiple sclerosis experience

4. © 2018
Health
Catalyst
Emerging Tools
• Internet of Things data
• Patient Generated Healthcare Data – subjective and objective
• Machine Learning tools
• Crowdsourcing genomes including blockchain/cryptocurrency
• Novel interoperability approaches
4

5. © 2018
Health
Catalyst
5
BIDMC@home

6. © 2018
Health
Catalyst
6
Hub for Wearables & Internet of Things

7. © 2018
Health
Catalyst
Machine Learning Projects
Priority Projects
1 Predict when a patient in the hospital will be discharged
2 Predict no shows for ambulatory appointments
3 Optimize operating rooms (OR) block allocation
Future Projects
4 Predict at the time of discharge the probability that the patient will be readmitted within 30 days
and make prescriptive decisions in order to minimize the number
5 Minimize the overall length of stay at the hospital by studying the interaction between the
Emergency Department (ED) and the main hospital at Beth Israel Deaconess Medical Center
(BIDMC); reduce number of patients that are readmitted within 30 days
6 Predict at the time of admission of a patient to the ED the probability that the patient will need
an ICU bed and for how long
7 Apply methods developed by the PI in the area of personalized medicine for particular
diseases; examples include but are not limited to diabetes, coronary heart disease, and breast
cancer
7

8. © 2018
Health
Catalyst
8

9. © 2018
Health
Catalyst
Harvard/MIT Blockchain Pilot
9
• Unify the medication lists of the community by writing medication
data to a public ledger
• Evaluating the reliability of a decentralized architecture
• Controlling privacy and access
• Understanding costs and scalability
• Enabling novel uses of data

10. © 2018
Health
Catalyst
Healthcare Analytics Summit 18
Sept. 11-13, Salt Lake, Grand America Hotel
TOBY COSGROVE, MD
former CEO and President of
Cleveland Clinic (2004-2017),
who as a cardiac surgeon
performed more than 22,000
operations and holds 30 patents
for medical innovations
KIM GOODSELL
the actualized ‘genomified,’ quantified,
digitalized “patient of the future," her debut at
the 2014 Future of Genomic Medicine
conference made headline news
announcing— “The patient from the future,
here today”
DANIEL KRAFT, MD
a Stanford and Harvard trained physician-
scientist, inventor, entrepreneur, and
innovator, Kraft is the Founder and Chair of
Exponential Medicine, a program that
explores convergent, rapidly developing
technologies and their potential in
biomedicine and healthcare
BRENT JAMES, MD
former Chief Quality Officer at
Intermountain Healthcare - known
internationally for his work in
clinical quality improvement,
patient safety, and the
infrastructure that underlies
successful improvement efforts
PENNY WHEELER, MD
President and Chief Executive
Officer of Allina Health,
returns a second time as one
of the most popular HAS
speakers ever
MARC RANDOLF
Co-founder of Netflix, Marc will
share the Netflixed story: how a
scrappy Silicon Valley startup
brought down Blockbuster and
the lessons that could be
applicable to healthcare
JILL HOGGARD GREEN
PhD, RN, Chief Operating Officer – Mission
Health and President – Mission Hospital,
and recently named to the 2017 Becker’s
Healthcare list of the country’s top Women
Hospital and Health System Leaders to
Know
ROBERT WACHTER, MD
global leader in healthcare safety,
quality, policy, IT; Chair of the
Department of Medicine, University of
California, San Francisco; best-selling
author, “The Digital Doctor: Hope, Hype
and Harm at the Dawn of Medicine’s
Computer Age”
More highlights
4 Digital Innovators (Keynotes)
AI Showcase (10 walkabout case studies)
Digitizing the Patient Showcase (10-12 stations)
28 Educational, Case Study, and Technical Breakouts
24 Analytics Walkabout Projects
More Networking (Introducing “Brain Date”)
CME Accreditation For Clinicians
5-Star Grand America Hotel Experience
96 Total Presentations
National keynotes
Employer
Innovation
Scott
Schreeve
MD, CEO, Crossover Health
Payer
Innovation
Kevin
Sears
Executive Director of Marketing
and Network Services, Cleveland
Clinic
Biosensor
Innovation
John
Rogers
PhD, Founding Director, Center
Bio-Integrated Electronics,
Northwestern University
Pricing
Innovation
Gene
Thompson
Project Director, Health City
Cayman Islands

11. Q&A

12. © 2018
Health
Catalyst
The Enterprise Data Warehouse (EDW) at Intermountain Healthcare went live in 1998. The EDW at Northwestern
Medicine went live in 2006. Dale Sanders was the chief architect and strategist for both. The business inspiration
behind Health Catalyst was, in essence, to create the commercial availability of the technology, analytics, and data
utilization skills associated with these systems at Intermountain and Northwestern.
Wednesday, May 30
1:00-2:00 PM EST
Learning Objectives:
• Data modeling is overrated but that's changing
• Hybrid architecture data lakes have arrived
• Text, images, and discrete data--together
• Will the EHR vendors meet the future? Track record says no
• Data governance hasn't yet found its sweet spot
20 Years in Healthcare Analytics & Data Warehousing
12
SHAKEEB AKHTER
LEE PIERCE
ANDREW WINTER
DALE SANDERS
President of Technology, Health Catalyst
Dale has been one of the most influential leaders
in healthcare analytics and data warehousing
since his earliest days in the industry, starting at
Intermountain Healthcare from 1997-2005,
where he was the chief architect for the
enterprise data warehouse (EDW) and regional
director of medical informatics at LDS Hospital.
Dale will be joined by:

13. Thank You!