With no known end to the COVID-19 social distancing directives, many healthcare organizations are shifting some team members to remote work arrangements. Clinicians offering telehealth services, case managers, as well as administrative, financial, and IT teams and others contributing away from the frontlines of care are candidates to work from home while continuing to support their organization’s operations. Though a shift in normal processes, research has shown that remote workers can be as or more productive as they are in the office setting and often report high levels of job satisfaction. Following best practices for remote-first work will help team members, managers, and organizations transition to and thrive in a distributed setting.