Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.

1. PROCESS DESIGN:
USING NANOPARTICLES IN
CANCER TREATMENT
HA NOI UNIVERSITY OF SCIENCE AND TECHNOLOGY
**** AdVANCEd training PROGRAM ****
Name : Hoàng Văn Tiến
Class : MSE-K54
ID Student : 20092697

2. CONTENT
• Problem
• Properties and characteristic of nanoparticles
• Use of nanoparticles in cancer treatment
• Applications and promises
• Summary

3. HOW MANY PEOPLE DIE FROM CANCER IN THE
WORLD EACH YEAR ?
• Approximately 7.6 million people die from cancer each year (according to
an article titled "ACS Report Focuses on Global Cancer Toll" which was
published by the American Cancer Society-2012)
• Viet Nam:
-240.000 – 250.000 people are being cancer
-150.000 new each year
-75.000 dead (2010 )
•

4. PROBLEM
Estimated cancer prevalence in the United States as of January 1, 2009
Males Females
All invasive cancer sites 12,549,000 5,809,000 6,740,000
Brain and other nervous system 135,000 71,000 65,000
Breast 2,762,000 14,000 2,747,000
Cervix 248,000 0 248,000
Colon & rectum 1,140,000 559,000 581,000
Endometrial cancer and Uterine
sarcoma
590,000 0 590,000

6. What Is NanoBiotechnology?
Nanodevices
Nanopores
Dendrimers
Nanotubes
Quantum dots
Nanoshells
Tennis ballA periodWhite
blood cell
Water
molecule

7. Nanoparticles Are
Small Enough to Enter Cells
Cell
White blood
cell
Water
molecule
Nanodevices
Nanoparticles
-Most animal cells are 10,000 to 20,000
nanometers in diameter.
 nanoscale devices (less than 100
nanometers) can enter cells and the organelles
inside them to interact with DNA and proteins.
Tools developed through nanotechnology may
be able to detect disease in a very small
amount of cells or tissue. They may also be
able to enter and monitor cells within a living
body.

8. Manufacturing Nanodevices
Scattered X-
rays
Atoms
in crystal
Detector
NanodevicesCrystal White blood
cell
CrystalX-ray
beam

11. Nanodevices Can Improve Cancer
Detection and Diagnosis
ImagingNanoBiotechnology Physical Exam,
Symptoms

12. Quantum Dots
Ultraviolet
light off
White
blood cell
Water
molecule
Nanodevices
Quantum dots
Quantum dots
emit light
Ultraviolet
light on
Quantum
dots
Quantum dot
bead

13. Quantum Dots Can
Find Cancer Signatures
Cancer cells
Healthy cells
Quantum dot beads
Quantum dot beads
Healthy cells
Cancer cells

14. Improving Cancer Treatment
Nanotechnology TreatmentTraditional Treatment
Intact noncancerous cells
Noncancerous cells
Toxins Nanodevices
Cancer
cells
Dead noncancerous cells
Noncancerous cells
Drugs
Dead
cancer
cells
Dead
cancer
cells
Toxins
Cancer
cells

15. Nanoshells
Nanoshell
White
blood cell
Water
molecule
Nanodevices
Nanoshells
Gold
Near-infrared light onNear-infrared light off
Nanoshell absorbs heat

16. − Nanoshells have metallic outer layer and silica core
− Selectively attracted to cancer shells either through a
phenomena called enhanced permeation retention or due to
some molecules coated on the shells
− The nanoshells are heated with an external energy source
killing the cancer cells
Thermal ablation of cancer cells

17. Nanoshells as Cancer Therapy
Nanoshells
Dead cancer cells
Nanoshells
Cancer
cells
Healthy cells
Intact healthy cells
Near-infrared light
Healthy cells
Cancer cells

18. - quantum dots to antibodies that guided them to prostate tumor sites in living
mice, where they clumped together and were visible using a simple mercury
lamp.

19. APPLICATIONS AND PROMISES
• Cantilevers Can Make Cancer Tests Faster and More
Efficient
• Kill the cancer cells without affect to other cells
• Can deliver more of the active ingredient and control
more precisely how quickly it is released compared with
current leading cancer drugs.

20. • Cancer treatment by grammar rays(US) : 15.000 – 25.000 USD
((300.000.000 – 500.000.000 vnd)
• Many new drug treatments cost nearly $100,000 a year
• $93,000 for vacxin which can adds four months' survival, on average, for
men with incurable prostate tumors.

21. POTENTIALS
• More cheaper than the traditional methods ( drug ,vacxin , UV ….)
• Low effect to the body (compare with Chemotherapy, Radiation Therapy…)
• Cancer treatment (until now) : tumor's natural recruitment of monocytes,
Liver Cancer Treatment, Lung Cancer Treatment, Vaginal Cancer
Treatment , Leukemia Treatment Overview….
• Bright futures in uses

22. CHALENGES
• Nanostructures can be so small that the body
may clear them too rapidly for them to be
effective in detection or imaging.
• Larger nanoparticles may accumulate in vital
organs, creating a toxicity problem.
• Difficult to approximate amount of nanopartiles
• Cytotoxic Effect

23. REFERENCES
• http://www.sciencedirect.com/science/article/pii/S1470204506707938
• http://triplehelixblog.com/2011/09/nanorobots-novel-technology-for-cancer-
therapy/
• http://www.nanotec.or.th/en/?p=3667
• Applications of gold nanoparticles in cancer nanotechnology -Weibo Cai
,Ting Gao,Hao Hong, Jiangtao Sun
• http://cancer.gov/cancertopics/understand
• en.wikipedia.org/wiki/Alternative_cancer_treatmentsingcancer
• Anti-Cancer Drug Loaded Iron–Gold Core–Shell Nanoparticles (Fe@Au)
for Magnetic Drug Targeting-Sibnath Kayal and Raju Vijayaraghavan
Ramanujan∗School of Materials Science and Engineering, Nanyang
Technological University, 639798, Singapore