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Informational macromolecules (2)

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Informational macromolecules

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INFORMATIONAL MACROMOLECULES Storage and Expression of Genetic Information
NUCLEOTIDES ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
STRUCTURE OF NUCLEOTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object]
Purine and Pyrimidine Structures ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Nucleosides ,[object Object],[object Object],[object Object],[object Object]
 
Structure of nucleosides
Mononucleotides ,[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object]
Nucleoside Diphosphate and Triphosphate ,[object Object],[object Object],[object Object],[object Object]
[object Object]
Nitrogenous bases,their nucleoside and nucleotide derivatives base ribonucleoside ribonucleotide deoxyribonucleoside deoxyribonucleotide adenine adenosine Adenosine monophosphate Deoxy-adenosine Deoxy-adenosine –mono-phosphate guanine guanosine Guanosine monophosphate Deoxy-guanosine Deoxy-guanosine-mono-phosphate cytosine cytidine Cytidine monophosphate Deoxy-cytidine Deoxy-cytidine-mono-phosphate uracil uridine Uridine monophosphate ----- ----- thymine --- ----- Deoxy-thymidine Deoxy-thymidine-mono-phosphate
Different nucleotides and their composition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiologic functions of biologically important nucleotides and nucleosides ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
Cyclic nucleotides ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Synthetic Analogs of Nucleosides and Nucleotides ,[object Object],[object Object],[object Object],[object Object],[object Object]
Some synthetic analogs:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Polynucleotides:- ,[object Object],[object Object],[object Object]
dinucleotude
NUCLEIC ACIDS ,[object Object],[object Object],[object Object]
DNA ,[object Object],[object Object],[object Object],[object Object],[object Object]
Structure of DNA ,[object Object],[object Object],[object Object]
Primary structure of DNA ,[object Object],[object Object],[object Object],[object Object],[object Object]
polynucleotide
Secondary structure of DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Structural forms of DNA double helix ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
The denaturation of DNA ,[object Object],[object Object],[object Object],[object Object],[object Object]
RIBONUCLEIC ACID (RNA) ,[object Object],[object Object],[object Object]
Structure of RNA ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
 
 
Differences between DNA and RNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classes of RNA:- ,[object Object],[object Object],[object Object],[object Object],[object Object]
A-MESSENGER RNA ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
TRANSFER RNA (tRNA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure of tRNA:- ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Ribosomal RNA ( rRNA) ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Small RNA ,[object Object]
[object Object],[object Object]
Biological significance of nucleotide metabolism ,[object Object],[object Object],[object Object],[object Object]
De-Novo SYNTHESIS OF PURINE NUCLEOTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object]
Materials required for Purine synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Steps of Biosynthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
Conversion of IMP to AMP ,[object Object],[object Object],[object Object]
Conversion of IMP to GMP ,[object Object],[object Object],[object Object],[object Object]
[object Object]
 
Formation of Nucleoside Diphosphates & Triphosphates ,[object Object],[object Object],[object Object]
Regulation/control of purine synthesis ,[object Object],[object Object],[object Object]
Inhibitors of purine synthesis ,[object Object],[object Object]
Salvage Pathway for Purines:- ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
1-conversion of free purines to their mononucleotide form:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2- Conversion of nucleosides to nucleotides:- ,[object Object],[object Object],[object Object]
Lesch-Nyhan Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object]
Synthesis of Deoxyribonucleotides:- ,[object Object],[object Object]
DEGRADATION OF PURINE NUCLEOTIDES/Uric acid formation ,[object Object],[object Object],[object Object]
Degradation of adenine nucleotides ,[object Object],[object Object],[object Object]
[object Object],[object Object]
Degradation of Guanine Nucleotides ,[object Object],[object Object],[object Object],[object Object]
Uric acid ,[object Object],[object Object],[object Object]
Clinical disorders of purine metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gout ,[object Object],[object Object],[object Object],[object Object],[object Object]
Primary Gout ,[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object]
Secondary Hyperuricemia ,[object Object],[object Object],[object Object]
Treatment of Gout ,[object Object],[object Object],[object Object]
Xanthinuria ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adenosine Deaminase Deficiency ,[object Object],[object Object],[object Object]
METABOLISM OF PYRIMIDINES

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Informational macromolecules (2)

  • 1. INFORMATIONAL MACROMOLECULES Storage and Expression of Genetic Information
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  • 15. Nitrogenous bases,their nucleoside and nucleotide derivatives base ribonucleoside ribonucleotide deoxyribonucleoside deoxyribonucleotide adenine adenosine Adenosine monophosphate Deoxy-adenosine Deoxy-adenosine –mono-phosphate guanine guanosine Guanosine monophosphate Deoxy-guanosine Deoxy-guanosine-mono-phosphate cytosine cytidine Cytidine monophosphate Deoxy-cytidine Deoxy-cytidine-mono-phosphate uracil uridine Uridine monophosphate ----- ----- thymine --- ----- Deoxy-thymidine Deoxy-thymidine-mono-phosphate
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