PRP Art & science

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islam kassem

PRP art &science

Health & Medicine

Platelet Rich Plasma
Art & science
Islam Kassem,BDS,MSc,FDS RCS
Consultant oral & maxillofacial Surgeon
ikassem@dr.com

Angle Face Left
New technology of injection
your own blood to get a
Youthful Look .
.
ikassem@dr.com

Why Are Celebrities
Injecting Their Faces
With Blood?
ikassem@dr.com

Platelet?
 Anuclear piece of cytoplasm
 Include hemostasis,
α-granule,lysosomal granule,
dense granules
ikassem@dr.com

 At least 7 different growth
factors that stimulate bone &
soft tissue healing
 PDGF aa,bb,ab
 TGF b1,b2
 VEGF
 EGF
ikassem@dr.com

7 days later
 PLT exhausted after 7 days
 Macrophage by low oxygen
tension, acidity, lactate
concentration
 Secrete same growth factors
 Activated until it is down
regulated by the restoration of
normal oxygen tension
ikassem@dr.com

17days
 Graft is completely permeated
by new capillaries
 Initial osteoid formation
 Osteoclast resorb osteoid and
BMP released
 New bone formation and
maturation
ikassem@dr.com

The mechanism of growth factor
effects on cells
Inactive state
ikassem@dr.com

Clinical effects of PRP on bone
regeneration
Platelet
RBC
Normal blood PRP
ikassem@dr.com

Trabecular areaNative mandible Autogenous BG
ikassem@dr.com

Clinical effects of PRP on soft tissue
healing
 Split thickness skin graft donor site healing
ikassem@dr.com

6 days
Thrombin side
: 5% epithelization
95% granulation
tissue
PRP side
; 95% epithelization
5% granulation
tissue
ikassem@dr.com

6 months
Thrombin side
: scarring
hypo and
hyper-
pigmentation
area
PRP side
;less scarring
Much less
pigmentation
change
ikassem@dr.com

Patient discomfort
 Patient
discomfort
decrease
ikassem@dr.com

Contraindications
 Pre-existing coagulation defect
: thrombocytopenia, hypofibrinogenia…
 Hypersensitivity to bovine thrombin
ikassem@dr.com

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PRP Art & science

1. Platelet Rich Plasma Art & science Islam Kassem,BDS,MSc,FDS RCS Consultant oral & maxillofacial Surgeon ikassem@dr.com

2. Angle Face Left New technology of injection your own blood to get a Youthful Look . . ikassem@dr.com

3. Why Are Celebrities Injecting Their Faces With Blood? ikassem@dr.com

4. ikassem@dr.com

5. Platelet?  Anuclear piece of cytoplasm  Include hemostasis, α-granule,lysosomal granule, dense granules ikassem@dr.com

6.  At least 7 different growth factors that stimulate bone & soft tissue healing  PDGF aa,bb,ab  TGF b1,b2  VEGF  EGF ikassem@dr.com

7. Days of operation ikassem@dr.com

8. 7 days later  PLT exhausted after 7 days  Macrophage by low oxygen tension, acidity, lactate concentration  Secrete same growth factors  Activated until it is down regulated by the restoration of normal oxygen tension ikassem@dr.com

9. Day 3rd ikassem@dr.com

10. 17days  Graft is completely permeated by new capillaries  Initial osteoid formation  Osteoclast resorb osteoid and BMP released  New bone formation and maturation ikassem@dr.com

11. Days 14 ikassem@dr.com

12. The mechanism of growth factor effects on cells Inactive state ikassem@dr.com

13. Activation activation ikassem@dr.com

14. Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP ikassem@dr.com

15. Trabecular areaNative mandible Autogenous BG ikassem@dr.com

16. Clinical effects of PRP on soft tissue healing  Split thickness skin graft donor site healing ikassem@dr.com

17. 6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue ikassem@dr.com

18. 6 months Thrombin side : scarring hypo and hyper- pigmentation area PRP side ;less scarring Much less pigmentation change ikassem@dr.com

19. Patient discomfort  Patient discomfort decrease ikassem@dr.com

20. Epithelization ikassem@dr.com

21. 6days ↔ ↔ ikassem@dr.com

22. 1 months ikassem@dr.com