This document summarizes information about depressive disorders including types of depression, prevalence, comorbidity with other disorders, course, genetic and environmental risk factors, delay in treatment, suicide risk factors, and treatment options. It discusses that major depression affects 16.6% of Americans in their lifetime. Treatment includes psychotherapy, natural remedies, self-help, and medication. Medications discussed are SSRIs, SNRIs, and older tricyclic antidepressants. Risks and benefits of antidepressant medication are described for both youths and adults.